Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/40142 |
Resumo: | Copyright © 2019 Leal, Rodrigues, Sousa, Duarte, Romão, Marques-Neves, Costa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trialsNon-infectious uveitisAnti-tumor necrosis factor drugsAdalimumabEtanerceptSafetyEfficacyCopyright © 2019 Leal, Rodrigues, Sousa, Duarte, Romão, Marques-Neves, Costa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Background: We aimed to assess efficacy and safety of anti-tumor necrosis factor (TNF) drugs for adult chronic non-infectious uveitis (NIU). Methods: CENTRAL, MEDLINE, and EMBASE, were searched from inception to January 2019. Double-masked randomized placebo-controlled trials, assessing any anti-TNF vs. best medical intervention/standard of care in adults with chronic NIU were considered. The PRISMA and SAMPL guidelines were followed. The risk of bias was assessed using the Cochrane risk of bias tool. Overall quality of the evidence was assessed according to GRADE. PROSPERO registration: #CRD42016039068. The primary efficacy and safety outcomes were preservation of visual acuity (VA) and withdrawals due to adverse events, respectively. Meta-analysis of efficacy analysis was not performed due to significant clinical heterogeneity between studies' population and interventions. Results: A total of 1,157 references were considered and 3 studies were included. The overall risk of bias was moderate. In active NIU, adalimumab group showed an increased likelihood of VA preservation (risk ratio (RR) 1.75, 95%CI 1.32 to 2.32, n = 217), whereas the etanercept group did not (RR 0.81, 95%CI 0.57 to 1.14, n = 20). In inactive NIU, adalimumab was associated with increased likelihood of VA preservation (RR 1.31, 95%CI 1.12 to 1.53, n = 226). The rate of adverse events did not differ between anti-TNF and control arms (RR 1.03, 95%CI 0.94 to 1.13, n = 410). Conclusions: There is high quality evidence that adalimumab decreases the risk of worsening VA in active and inactive NIU and very low quality evidence that the risk of etanercept worsening VA in inactive NIU is not different from placebo. Moderate quality evidence suggests that anti-TNF agents are not different from placebo on the risk of study withdrawal.This project received a research grant from a non-profit and scientific organization, Portuguese Society of Ophthalmology (Sociedade Portuguesa de Oftalmologia). UID/BIM/50005/2019, project funded by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado (Portuguese State Funding).Frontiers MediaRepositório da Universidade de LisboaLeal, InesRodrigues, Filipe BrogueiraSousa, David CordeiroDuarte, Gonçalo SilvaRomão, Vasco C.Marques-Neves, CarlosCosta, JoãoFonseca, João Eurico2019-11-14T14:54:45Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/40142engFrontiers in Medicine | May 2019 | Volume 6 | Article 10410.3389/fmed.2019.001042296-858Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:39:16Zoai:repositorio.ul.pt:10451/40142Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:53:52.100489Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| title |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| spellingShingle |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials Leal, Ines Non-infectious uveitis Anti-tumor necrosis factor drugs Adalimumab Etanercept Safety Efficacy |
| title_short |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| title_full |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| title_sort |
Anti-TNF drugs for chronic uveitis in adults : a systematic review and meta-analysis of randomized controlled trials |
| author |
Leal, Ines |
| author_facet |
Leal, Ines Rodrigues, Filipe Brogueira Sousa, David Cordeiro Duarte, Gonçalo Silva Romão, Vasco C. Marques-Neves, Carlos Costa, João Fonseca, João Eurico |
| author_role |
author |
| author2 |
Rodrigues, Filipe Brogueira Sousa, David Cordeiro Duarte, Gonçalo Silva Romão, Vasco C. Marques-Neves, Carlos Costa, João Fonseca, João Eurico |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Leal, Ines Rodrigues, Filipe Brogueira Sousa, David Cordeiro Duarte, Gonçalo Silva Romão, Vasco C. Marques-Neves, Carlos Costa, João Fonseca, João Eurico |
| dc.subject.por.fl_str_mv |
Non-infectious uveitis Anti-tumor necrosis factor drugs Adalimumab Etanercept Safety Efficacy |
| topic |
Non-infectious uveitis Anti-tumor necrosis factor drugs Adalimumab Etanercept Safety Efficacy |
| description |
Copyright © 2019 Leal, Rodrigues, Sousa, Duarte, Romão, Marques-Neves, Costa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-11-14T14:54:45Z 2019 2019-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/40142 |
| url |
http://hdl.handle.net/10451/40142 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Frontiers in Medicine | May 2019 | Volume 6 | Article 104 10.3389/fmed.2019.00104 2296-858X |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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