Multidrug efflux pumps in Staphylococcus aureus: an update.

Detalhes bibliográficos
Autor(a) principal: Costa, SS
Data de Publicação: 2013
Outros Autores: Bettencourt, Miguel Viveiros, Amaral, Leonard, Couto, Isabel Maria dos Santos Leitão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/116937
Resumo: The emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pumps, proteins that cells use to detoxify from noxious compounds, seem to play a key role in the emergence of these multidrug resistant (MDR) bacteria. During the last decades, experimental data has established their contribution to low level resistance to antimicrobials in bacteria and their potential role in the appearance of MDR phenotypes, by the extrusion of multiple, unrelated compounds. Recent studies suggest that efflux pumps may be used by the cell as a first-line defense mechanism, avoiding the drug to reach lethal concentrations, until a stable, more efficient alteration occurs, that allows survival in the presence of that agent. In this paper we review the current knowledge on MDR efflux pumps and their intricate regulatory network in Staphylococcus aureus, a major pathogen, responsible from mild to life-threatening infections. Particular emphasis will be given to the potential role that S. aureus MDR efflux pumps, either chromosomal or plasmid-encoded, have on resistance towards different antimicrobial agents and on the selection of drug - resistant strains. We will also discuss the many questions that still remain on the role of each specific efflux pump and the need to establish appropriate methodological approaches to address all these questions.
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spelling Multidrug efflux pumps in Staphylococcus aureus: an update.Biochemistry, Genetics and Molecular Biology (miscellaneous)Infectious DiseasesSDG 3 - Good Health and Well-beingThe emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pumps, proteins that cells use to detoxify from noxious compounds, seem to play a key role in the emergence of these multidrug resistant (MDR) bacteria. During the last decades, experimental data has established their contribution to low level resistance to antimicrobials in bacteria and their potential role in the appearance of MDR phenotypes, by the extrusion of multiple, unrelated compounds. Recent studies suggest that efflux pumps may be used by the cell as a first-line defense mechanism, avoiding the drug to reach lethal concentrations, until a stable, more efficient alteration occurs, that allows survival in the presence of that agent. In this paper we review the current knowledge on MDR efflux pumps and their intricate regulatory network in Staphylococcus aureus, a major pathogen, responsible from mild to life-threatening infections. Particular emphasis will be given to the potential role that S. aureus MDR efflux pumps, either chromosomal or plasmid-encoded, have on resistance towards different antimicrobial agents and on the selection of drug - resistant strains. We will also discuss the many questions that still remain on the role of each specific efflux pump and the need to establish appropriate methodological approaches to address all these questions.Instituto de Higiene e Medicina Tropical (IHMT)CREM - Centro de Recursos MicrobiológicosRUNCosta, SSBettencourt, Miguel ViveirosAmaral, LeonardCouto, Isabel Maria dos Santos Leitão2021-05-04T22:31:14Z2013-01-012013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/116937eng1874-2858PURE: 157905https://doi.org/10.2174/1874285801307010059info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:50Zoai:run.unl.pt:10362/116937Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:23.236515Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Multidrug efflux pumps in Staphylococcus aureus: an update.
title Multidrug efflux pumps in Staphylococcus aureus: an update.
spellingShingle Multidrug efflux pumps in Staphylococcus aureus: an update.
Costa, SS
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Multidrug efflux pumps in Staphylococcus aureus: an update.
title_full Multidrug efflux pumps in Staphylococcus aureus: an update.
title_fullStr Multidrug efflux pumps in Staphylococcus aureus: an update.
title_full_unstemmed Multidrug efflux pumps in Staphylococcus aureus: an update.
title_sort Multidrug efflux pumps in Staphylococcus aureus: an update.
author Costa, SS
author_facet Costa, SS
Bettencourt, Miguel Viveiros
Amaral, Leonard
Couto, Isabel Maria dos Santos Leitão
author_role author
author2 Bettencourt, Miguel Viveiros
Amaral, Leonard
Couto, Isabel Maria dos Santos Leitão
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
CREM - Centro de Recursos Microbiológicos
RUN
dc.contributor.author.fl_str_mv Costa, SS
Bettencourt, Miguel Viveiros
Amaral, Leonard
Couto, Isabel Maria dos Santos Leitão
dc.subject.por.fl_str_mv Biochemistry, Genetics and Molecular Biology (miscellaneous)
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Biochemistry, Genetics and Molecular Biology (miscellaneous)
Infectious Diseases
SDG 3 - Good Health and Well-being
description The emergence of infections caused by multi- or pan-resistant bacteria in the hospital or in the community settings is an increasing health concern. Albeit there is no single resistance mechanism behind multiresistance, multidrug efflux pumps, proteins that cells use to detoxify from noxious compounds, seem to play a key role in the emergence of these multidrug resistant (MDR) bacteria. During the last decades, experimental data has established their contribution to low level resistance to antimicrobials in bacteria and their potential role in the appearance of MDR phenotypes, by the extrusion of multiple, unrelated compounds. Recent studies suggest that efflux pumps may be used by the cell as a first-line defense mechanism, avoiding the drug to reach lethal concentrations, until a stable, more efficient alteration occurs, that allows survival in the presence of that agent. In this paper we review the current knowledge on MDR efflux pumps and their intricate regulatory network in Staphylococcus aureus, a major pathogen, responsible from mild to life-threatening infections. Particular emphasis will be given to the potential role that S. aureus MDR efflux pumps, either chromosomal or plasmid-encoded, have on resistance towards different antimicrobial agents and on the selection of drug - resistant strains. We will also discuss the many questions that still remain on the role of each specific efflux pump and the need to establish appropriate methodological approaches to address all these questions.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2013-01-01T00:00:00Z
2021-05-04T22:31:14Z
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https://doi.org/10.2174/1874285801307010059
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