Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

Govarts, Eva; Gilles, Liese; Rodriguez Martin, Laura; Santonen, Tiina; Apel, Petra; Alvito, Paula; Anastasi, Elena; Andersen, Helle Raun; Andersson, Anna-Maria; Andryskova, Lenka; ANTIGNAC, Jean-Philippe; Rüther, Maria; Sarigiannis, Denis; Silva, Maria João; Šlejkovec, Zdenka; Snoj Tratnik, Janja; Stajnko, Anja; Szigeti, Tamas; Tarazona, Jose; Thomsen, Cathrine; Tkalec, Žiga; Trnovec, Tomas; Tolonen, Hanna; Uhl, Maria; Van Nieuwenhuyse, An; Vasco, Elsa; Verheyen, Veerle J.; Viegas, Susana; Vinggaard, Anne Marie; Vogel, Nina; Vorkamp, Katrin; Wasowicz, Wojciech; Wimmerova, Sona; Weber, Till; Woutersen, Marjolijn; Zimmermann, Philipp; Zvonar, Martin; Koch, Holger; Kolossa-Gehring, Marike; Esteban López, Marta; Castano, Argelia; Stewart, Lorraine; Sepai, Ovnair; Appenzeller, Brice; Schoeters, Greta; Barbone, Fabio; Barnett-Itzhaki, Zohar; Barouki, Robert; Berman, Tamar; Bil, Wieneke; Borges, Teresa; Buekers, Jurgen; Cañas-Portilla, Ana; Covaci, Adrian; Csako, Zsofia; Den Hond, Elly; Dvorakova, Darina; Fabelova, Lucia; Fletcher, Tony; Frederiksen, Hanne; Gabriel, Catherine; Ganzleben, Catherine; Göen, Thomas; Halldorsson, Thorhallur; Haug, Line Småstuen; Horvat, Milena; Huuskonen, Pasi; Imboden, Medea; Jagodic Hudobivnik, Marta; Janasik, Beata; Janev Holcer, Natasa; Karakitsios, Spyros; Katsonouri, Andromachi; Klanova, Jana; Kokaraki, Venetia; Kold Jensen, Tina; Koponen, Jani; Laeremans, Michelle; Laguzzi, Federica; Lange, Rosa; Lemke, Nora; Lignell, Sanna; Lindroos, Anna Karin; Lobo Vicente, Joana; Luijten, Mirjam; Makris, Konstantinos C.; Mazej, Darja; Melymuk, Lisa; Meslin, Matthieu; Mol, Hans; Montazeri, Parisa; Murawski, Aline; Namorado, Sónia; Niemann, Lars; Nübler, Stefanie; Nunes, Baltazar; Olafsdottir, Kristin; Palkovicova Murinova, Lubica; Papaioannou, Nafsika; Pedraza-Diaz, Susana; Piler, Pavel; Plichta, Veronika; Poteser, Michael; Probst-Hensch, Nicole; Rambaud, Loic; Rauscher-Gabernig, Elke; Rausova, Katarina; Remy, Sylvie; Riou, Margaux; Rosolen, Valentina; Rousselle, Christophe

Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

Detalhes bibliográficos
Autor(a) principal:	Govarts, Eva
Data de Publicação:	2023
Outros Autores:	Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, ANTIGNAC, Jean-Philippe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria João, Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, Jose, Thomsen, Cathrine, Tkalec, Žiga, Trnovec, Tomas, Tolonen, Hanna, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Wimmerova, Sona, Weber, Till, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castano, Argelia, Stewart, Lorraine, Sepai, Ovnair, Appenzeller, Brice, Schoeters, Greta, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur, Haug, Line Småstuen, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loic, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10400.18/8665
Resumo:	Review

Metadados do item

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oai_identifier_str	oai:repositorio.insa.pt:10400.18/8664
network_acronym_str	RCAP
network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)Determinantes da Saúde e da DoençaDeterminants of Health and DiseaseObservação em Saúde e VigilânciaObservation in Health and SurveillanceGenotoxicidade AmbientalEnvironmental GenotoxicityBiomonitorização HumanaHuman BiomonitoringHBM4EUAligned StudiesEuropaEuropeChildrenCriançasTeenagersAdolescentesAdultsAdultosExposure BiomarkersBiomarcadores de ExposiçãoAvaliação do RiscoRisk AssessmentReviewAbstract: As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures.Highlights: Harmonized EU-wide HBM survey in 10,795 participants covering 11 chemical groups; Both legacy compounds and their substitutes are ubiquitous; Social and geographical gradients in internal exposure are observed; Higher biomarker concentrations observed in younger age groups; For 15 out of 20 biomarkers health risks cannot be excluded.HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contrib uting studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12.ElsevierRepositório Científico do Instituto Nacional de SaúdeGovarts, EvaGilles, LieseRodriguez Martin, LauraSantonen, TiinaApel, PetraAlvito, PaulaAnastasi, ElenaAndersen, Helle RaunAndersson, Anna-MariaAndryskova, LenkaANTIGNAC, Jean-PhilippeRüther, MariaSarigiannis, DenisSilva, Maria JoãoŠlejkovec, ZdenkaSnoj Tratnik, JanjaStajnko, AnjaSzigeti, TamasTarazona, JoseThomsen, CathrineTkalec, ŽigaTrnovec, TomasTolonen, HannaUhl, MariaVan Nieuwenhuyse, AnVasco, ElsaVerheyen, Veerle J.Viegas, SusanaVinggaard, Anne MarieVogel, NinaVorkamp, KatrinWasowicz, WojciechWimmerova, SonaWeber, TillWoutersen, MarjolijnZimmermann, PhilippZvonar, MartinKoch, HolgerKolossa-Gehring, MarikeEsteban López, MartaCastano, ArgeliaStewart, LorraineSepai, OvnairAppenzeller, BriceSchoeters, GretaBarbone, FabioBarnett-Itzhaki, ZoharBarouki, RobertBerman, TamarBil, WienekeBorges, TeresaBuekers, JurgenCañas-Portilla, AnaCovaci, AdrianCsako, ZsofiaDen Hond, EllyDvorakova, DarinaFabelova, LuciaFletcher, TonyFrederiksen, HanneGabriel, CatherineGanzleben, CatherineGöen, ThomasHalldorsson, ThorhallurHaug, Line SmåstuenHorvat, MilenaHuuskonen, PasiImboden, MedeaJagodic Hudobivnik, MartaJanasik, BeataJanev Holcer, NatasaKarakitsios, SpyrosKatsonouri, AndromachiKlanova, JanaKokaraki, VenetiaKold Jensen, TinaKoponen, JaniLaeremans, MichelleLaguzzi, FedericaLange, RosaLemke, NoraLignell, SannaLindroos, Anna KarinLobo Vicente, JoanaLuijten, MirjamMakris, Konstantinos C.Mazej, DarjaMelymuk, LisaMeslin, MatthieuMol, HansMontazeri, ParisaMurawski, AlineNamorado, SóniaNiemann, LarsNübler, StefanieNunes, BaltazarOlafsdottir, KristinPalkovicova Murinova, LubicaPapaioannou, NafsikaPedraza-Diaz, SusanaPiler, PavelPlichta, VeronikaPoteser, MichaelProbst-Hensch, NicoleRambaud, LoicRauscher-Gabernig, ElkeRausova, KatarinaRemy, SylvieRiou, MargauxRosolen, ValentinaRousselle, Christophe2023-10-06T11:04:15Z2023-02-092023-02-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8665engInt J Hyg Environ Health. 2023 Apr:249:114119. doi: 10.1016/j.ijheh.2023.114119. Epub 2023 Feb 9. Review1438-463910.1016/j.ijheh.2023.114119info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:31:33Zoai:repositorio.insa.pt:10400.18/8664Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:34.058889Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
spellingShingle	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021) Govarts, Eva Determinantes da Saúde e da Doença Determinants of Health and Disease Observação em Saúde e Vigilância Observation in Health and Surveillance Genotoxicidade Ambiental Environmental Genotoxicity Biomonitorização Humana Human Biomonitoring HBM4EU Aligned Studies Europa Europe Children Crianças Teenagers Adolescentes Adults Adultos Exposure Biomarkers Biomarcadores de Exposição Avaliação do Risco Risk Assessment
title_short	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_full	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_fullStr	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_full_unstemmed	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
title_sort	Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)
author	Govarts, Eva
author_facet	Govarts, Eva Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna-Maria Andryskova, Lenka ANTIGNAC, Jean-Philippe Rüther, Maria Sarigiannis, Denis Silva, Maria João Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamas Tarazona, Jose Thomsen, Cathrine Tkalec, Žiga Trnovec, Tomas Tolonen, Hanna Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J. Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Wimmerova, Sona Weber, Till Woutersen, Marjolijn Zimmermann, Philipp Zvonar, Martin Koch, Holger Kolossa-Gehring, Marike Esteban López, Marta Castano, Argelia Stewart, Lorraine Sepai, Ovnair Appenzeller, Brice Schoeters, Greta Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas-Portilla, Ana Covaci, Adrian Csako, Zsofia Den Hond, Elly Dvorakova, Darina Fabelova, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldorsson, Thorhallur Haug, Line Småstuen Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klanova, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C. Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Olafsdottir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loic Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe
author_role	author
author2	Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna-Maria Andryskova, Lenka ANTIGNAC, Jean-Philippe Rüther, Maria Sarigiannis, Denis Silva, Maria João Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamas Tarazona, Jose Thomsen, Cathrine Tkalec, Žiga Trnovec, Tomas Tolonen, Hanna Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J. Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Wimmerova, Sona Weber, Till Woutersen, Marjolijn Zimmermann, Philipp Zvonar, Martin Koch, Holger Kolossa-Gehring, Marike Esteban López, Marta Castano, Argelia Stewart, Lorraine Sepai, Ovnair Appenzeller, Brice Schoeters, Greta Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas-Portilla, Ana Covaci, Adrian Csako, Zsofia Den Hond, Elly Dvorakova, Darina Fabelova, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldorsson, Thorhallur Haug, Line Småstuen Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klanova, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C. Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Olafsdottir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loic Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv	Govarts, Eva Gilles, Liese Rodriguez Martin, Laura Santonen, Tiina Apel, Petra Alvito, Paula Anastasi, Elena Andersen, Helle Raun Andersson, Anna-Maria Andryskova, Lenka ANTIGNAC, Jean-Philippe Rüther, Maria Sarigiannis, Denis Silva, Maria João Šlejkovec, Zdenka Snoj Tratnik, Janja Stajnko, Anja Szigeti, Tamas Tarazona, Jose Thomsen, Cathrine Tkalec, Žiga Trnovec, Tomas Tolonen, Hanna Uhl, Maria Van Nieuwenhuyse, An Vasco, Elsa Verheyen, Veerle J. Viegas, Susana Vinggaard, Anne Marie Vogel, Nina Vorkamp, Katrin Wasowicz, Wojciech Wimmerova, Sona Weber, Till Woutersen, Marjolijn Zimmermann, Philipp Zvonar, Martin Koch, Holger Kolossa-Gehring, Marike Esteban López, Marta Castano, Argelia Stewart, Lorraine Sepai, Ovnair Appenzeller, Brice Schoeters, Greta Barbone, Fabio Barnett-Itzhaki, Zohar Barouki, Robert Berman, Tamar Bil, Wieneke Borges, Teresa Buekers, Jurgen Cañas-Portilla, Ana Covaci, Adrian Csako, Zsofia Den Hond, Elly Dvorakova, Darina Fabelova, Lucia Fletcher, Tony Frederiksen, Hanne Gabriel, Catherine Ganzleben, Catherine Göen, Thomas Halldorsson, Thorhallur Haug, Line Småstuen Horvat, Milena Huuskonen, Pasi Imboden, Medea Jagodic Hudobivnik, Marta Janasik, Beata Janev Holcer, Natasa Karakitsios, Spyros Katsonouri, Andromachi Klanova, Jana Kokaraki, Venetia Kold Jensen, Tina Koponen, Jani Laeremans, Michelle Laguzzi, Federica Lange, Rosa Lemke, Nora Lignell, Sanna Lindroos, Anna Karin Lobo Vicente, Joana Luijten, Mirjam Makris, Konstantinos C. Mazej, Darja Melymuk, Lisa Meslin, Matthieu Mol, Hans Montazeri, Parisa Murawski, Aline Namorado, Sónia Niemann, Lars Nübler, Stefanie Nunes, Baltazar Olafsdottir, Kristin Palkovicova Murinova, Lubica Papaioannou, Nafsika Pedraza-Diaz, Susana Piler, Pavel Plichta, Veronika Poteser, Michael Probst-Hensch, Nicole Rambaud, Loic Rauscher-Gabernig, Elke Rausova, Katarina Remy, Sylvie Riou, Margaux Rosolen, Valentina Rousselle, Christophe
dc.subject.por.fl_str_mv	Determinantes da Saúde e da Doença Determinants of Health and Disease Observação em Saúde e Vigilância Observation in Health and Surveillance Genotoxicidade Ambiental Environmental Genotoxicity Biomonitorização Humana Human Biomonitoring HBM4EU Aligned Studies Europa Europe Children Crianças Teenagers Adolescentes Adults Adultos Exposure Biomarkers Biomarcadores de Exposição Avaliação do Risco Risk Assessment
topic	Determinantes da Saúde e da Doença Determinants of Health and Disease Observação em Saúde e Vigilância Observation in Health and Surveillance Genotoxicidade Ambiental Environmental Genotoxicity Biomonitorização Humana Human Biomonitoring HBM4EU Aligned Studies Europa Europe Children Crianças Teenagers Adolescentes Adults Adultos Exposure Biomarkers Biomarcadores de Exposição Avaliação do Risco Risk Assessment
description	Review
publishDate	2023
dc.date.none.fl_str_mv	2023-10-06T11:04:15Z 2023-02-09 2023-02-09T00:00:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10400.18/8665
url	http://hdl.handle.net/10400.18/8665
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Int J Hyg Environ Health. 2023 Apr:249:114119. doi: 10.1016/j.ijheh.2023.114119. Epub 2023 Feb 9. Review 1438-4639 10.1016/j.ijheh.2023.114119
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

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