Renin-angiotensin system in lung tumor and microenvironment interactions

Detalhes bibliográficos
Autor(a) principal: Catarata, MJ
Data de Publicação: 2020
Outros Autores: Ribeiro, R, Oliveira, MJ, Cordeiro, CR, Medeiros, R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/143500
Resumo: The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
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spelling Renin-angiotensin system in lung tumor and microenvironment interactionsHypoxiaLung cancerRenin-angiotensinTumor microenvironmentThe mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.MDPI20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/143500eng2072-669410.3390/cancers12061457Catarata, MJRibeiro, ROliveira, MJCordeiro, CRMedeiros, Rinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:02:42Zoai:repositorio-aberto.up.pt:10216/143500Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:32:28.136209Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Renin-angiotensin system in lung tumor and microenvironment interactions
title Renin-angiotensin system in lung tumor and microenvironment interactions
spellingShingle Renin-angiotensin system in lung tumor and microenvironment interactions
Catarata, MJ
Hypoxia
Lung cancer
Renin-angiotensin
Tumor microenvironment
title_short Renin-angiotensin system in lung tumor and microenvironment interactions
title_full Renin-angiotensin system in lung tumor and microenvironment interactions
title_fullStr Renin-angiotensin system in lung tumor and microenvironment interactions
title_full_unstemmed Renin-angiotensin system in lung tumor and microenvironment interactions
title_sort Renin-angiotensin system in lung tumor and microenvironment interactions
author Catarata, MJ
author_facet Catarata, MJ
Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
author_role author
author2 Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Catarata, MJ
Ribeiro, R
Oliveira, MJ
Cordeiro, CR
Medeiros, R
dc.subject.por.fl_str_mv Hypoxia
Lung cancer
Renin-angiotensin
Tumor microenvironment
topic Hypoxia
Lung cancer
Renin-angiotensin
Tumor microenvironment
description The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/143500
url https://hdl.handle.net/10216/143500
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
10.3390/cancers12061457
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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