Pediatric Multiple Sclerosis in Portugal: A Multicentre Study
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346 |
Resumo: | Introduction: Multiple sclerosis is most often diagnosed among young adults but less frequently it may present during childhood or adolescence. In Portugal, there has been only one previous single-center, pediatric multiple sclerosis study. The main objective was the evaluation of the demographic, clinical, laboratorial and neuroradiological characteristics of patients with pediatric-onset multiple sclerosis in Portugal. The secondary objectives were to compare the characteristics of childhood-onset multiple sclerosis and adolescent-onset multiple sclerosis and to characterize the treatments prescribed.Material and Methods: We performed a retrospective observational, multicentric study. We reviewed data of all patients with multiple sclerosis younger than 18 years at the onset of their first multiple sclerosis symptoms.Results: There were 46 patients (72% female) included with a mean age at diagnosis of 16.1 years. Six cases had childhood-onset and 40 cases had adolescence-onset. The median value of Expanded Disability Status Scale was two. Relapsing-remitting multiple sclerosis was most prevalent (98% of cases). In the cerebrospinal fluid study, 74% of patients had positive oligoclonal bands. Brain magnetic resonance imaging studies showed a predominant supratentorial involvement (98% of cases), whereas the cervical segment was the most frequently affected in the spinal cord. All the patients enrolled in the study underwent immunomodulatory therapy, 75% ofpatients with beta-interferon. Concerning differences between the childhood and the adolescent groups, we found a greater proportion of male patients and of individuals with cerebrospinal fluid pleocytosis among the childhood-onset group.Discussion: This study provides new data on pediatric multiple sclerosis characteristics in Portugal and our results are similar to previously reported data in other parts of the worldConclusion: This is the first multicentric study characterizing pediatric multiple sclerosis in Portugal. The mechanisms underlying the particularities of pediatric multiple sclerosis remain largely unknown and further studies are required. |
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Pediatric Multiple Sclerosis in Portugal: A Multicentre StudyEsclerose Múltipla Pediátrica em Portugal: Um Estudo MulticêntricoAdolescentChildMultiple SclerosisPortugal.AdolescenteCriançaEsclerose MúltiplaPortugal.Introduction: Multiple sclerosis is most often diagnosed among young adults but less frequently it may present during childhood or adolescence. In Portugal, there has been only one previous single-center, pediatric multiple sclerosis study. The main objective was the evaluation of the demographic, clinical, laboratorial and neuroradiological characteristics of patients with pediatric-onset multiple sclerosis in Portugal. The secondary objectives were to compare the characteristics of childhood-onset multiple sclerosis and adolescent-onset multiple sclerosis and to characterize the treatments prescribed.Material and Methods: We performed a retrospective observational, multicentric study. We reviewed data of all patients with multiple sclerosis younger than 18 years at the onset of their first multiple sclerosis symptoms.Results: There were 46 patients (72% female) included with a mean age at diagnosis of 16.1 years. Six cases had childhood-onset and 40 cases had adolescence-onset. The median value of Expanded Disability Status Scale was two. Relapsing-remitting multiple sclerosis was most prevalent (98% of cases). In the cerebrospinal fluid study, 74% of patients had positive oligoclonal bands. Brain magnetic resonance imaging studies showed a predominant supratentorial involvement (98% of cases), whereas the cervical segment was the most frequently affected in the spinal cord. All the patients enrolled in the study underwent immunomodulatory therapy, 75% ofpatients with beta-interferon. Concerning differences between the childhood and the adolescent groups, we found a greater proportion of male patients and of individuals with cerebrospinal fluid pleocytosis among the childhood-onset group.Discussion: This study provides new data on pediatric multiple sclerosis characteristics in Portugal and our results are similar to previously reported data in other parts of the worldConclusion: This is the first multicentric study characterizing pediatric multiple sclerosis in Portugal. The mechanisms underlying the particularities of pediatric multiple sclerosis remain largely unknown and further studies are required.Introdução: A esclerose múltipla é habitualmente diagnosticada em adultos jovens mas, mais raramente, pode manifestar-se durante a infância ou adolescência. Os dados sobre a esclerose múltipla pediátrica em Portugal são escassos. O objectivo principal deste estudo é a avaliação das características demográficas, clínicas, laboratoriais e neurorradiológicas da esclerose múltipla de início em idade pediátrica em Portugal. Os objetivos secundários consistem na comparação entre a esclerose múltipla de início na infância e aesclerose múltipla de início na adolescência e na caracterização dos tratamentos prescritos.Material e Métodos: Realizou-se um estudo retrospectivo, observacional e multicêntrico, que consistiu na análise dos dados de todos os doentes com apresentação da EM antes dos 18 anos.Resultados: Incluíram-se 46 doentes (72% do sexo feminino), com uma idade média de diagnóstico de 16,1 anos. Seis casos tiveram início na infância, 40 na adolescência. A esclerose múltipla apresentou-se em 98% dos casos com a forma surto-remissão. O estudo do líquor revelou bandas oligoclonais em 74% dos doentes. A ressonância magnética encefálica mostrou predominantemente lesões supratentoriais (98% dos casos), enquanto que a ressonância medular revelou que o segmento cervical foi o mais frequentemente afectado. Todos os doentes iniciaram terapêutica imunomoduladora (75% com interferão β). Relativamente às diferenças entre os dois grupos etários, encontrámos uma maior proporção de doentes do sexo masculino e com pleocitose no grupo com apresentação nainfância.Discussão: Este trabalho fornece novos dados sobre as características da esclerose múltipla pediátrica em Portugal e os resultados são semelhantes aos reportados em outras partes do mundo.Conclusão: Este é o primeiro estudo multicêntrico português sobre a esclerose múltipla com apresentação na infância e adolescência. Mais estudos são necessários para clarificar os mecanismos subjacentes às particularidades da esclerose múltipla pediátrica.Ordem dos Médicos2016-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/mswordapplication/mswordapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346oai:ojs.www.actamedicaportuguesa.com:article/6346Acta Médica Portuguesa; Vol. 29 No. 7-8 (2016): July-August; 425-431Acta Médica Portuguesa; Vol. 29 N.º 7-8 (2016): Julho-Agosto; 425-4311646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/4727https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/7769https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/7920https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/8009https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/8054Direitos de Autor (c) 2016 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessCorreia, Ana SofiaAugusto, LuísMeireles, JoanaPinto, JoanaSousa, Ana Paula2022-12-20T11:04:49Zoai:ojs.www.actamedicaportuguesa.com:article/6346Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:17.844231Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study Esclerose Múltipla Pediátrica em Portugal: Um Estudo Multicêntrico |
title |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study |
spellingShingle |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study Correia, Ana Sofia Adolescent Child Multiple Sclerosis Portugal. Adolescente Criança Esclerose Múltipla Portugal. |
title_short |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study |
title_full |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study |
title_fullStr |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study |
title_full_unstemmed |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study |
title_sort |
Pediatric Multiple Sclerosis in Portugal: A Multicentre Study |
author |
Correia, Ana Sofia |
author_facet |
Correia, Ana Sofia Augusto, Luís Meireles, Joana Pinto, Joana Sousa, Ana Paula |
author_role |
author |
author2 |
Augusto, Luís Meireles, Joana Pinto, Joana Sousa, Ana Paula |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Correia, Ana Sofia Augusto, Luís Meireles, Joana Pinto, Joana Sousa, Ana Paula |
dc.subject.por.fl_str_mv |
Adolescent Child Multiple Sclerosis Portugal. Adolescente Criança Esclerose Múltipla Portugal. |
topic |
Adolescent Child Multiple Sclerosis Portugal. Adolescente Criança Esclerose Múltipla Portugal. |
description |
Introduction: Multiple sclerosis is most often diagnosed among young adults but less frequently it may present during childhood or adolescence. In Portugal, there has been only one previous single-center, pediatric multiple sclerosis study. The main objective was the evaluation of the demographic, clinical, laboratorial and neuroradiological characteristics of patients with pediatric-onset multiple sclerosis in Portugal. The secondary objectives were to compare the characteristics of childhood-onset multiple sclerosis and adolescent-onset multiple sclerosis and to characterize the treatments prescribed.Material and Methods: We performed a retrospective observational, multicentric study. We reviewed data of all patients with multiple sclerosis younger than 18 years at the onset of their first multiple sclerosis symptoms.Results: There were 46 patients (72% female) included with a mean age at diagnosis of 16.1 years. Six cases had childhood-onset and 40 cases had adolescence-onset. The median value of Expanded Disability Status Scale was two. Relapsing-remitting multiple sclerosis was most prevalent (98% of cases). In the cerebrospinal fluid study, 74% of patients had positive oligoclonal bands. Brain magnetic resonance imaging studies showed a predominant supratentorial involvement (98% of cases), whereas the cervical segment was the most frequently affected in the spinal cord. All the patients enrolled in the study underwent immunomodulatory therapy, 75% ofpatients with beta-interferon. Concerning differences between the childhood and the adolescent groups, we found a greater proportion of male patients and of individuals with cerebrospinal fluid pleocytosis among the childhood-onset group.Discussion: This study provides new data on pediatric multiple sclerosis characteristics in Portugal and our results are similar to previously reported data in other parts of the worldConclusion: This is the first multicentric study characterizing pediatric multiple sclerosis in Portugal. The mechanisms underlying the particularities of pediatric multiple sclerosis remain largely unknown and further studies are required. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346 oai:ojs.www.actamedicaportuguesa.com:article/6346 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346 |
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oai:ojs.www.actamedicaportuguesa.com:article/6346 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/4727 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/7769 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/7920 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/8009 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6346/8054 |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa info:eu-repo/semantics/openAccess |
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Direitos de Autor (c) 2016 Acta Médica Portuguesa |
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openAccess |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 29 No. 7-8 (2016): July-August; 425-431 Acta Médica Portuguesa; Vol. 29 N.º 7-8 (2016): Julho-Agosto; 425-431 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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