Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors

Detalhes bibliográficos
Autor(a) principal: Abrahão-Machado, Lucas Faria
Data de Publicação: 2018
Outros Autores: Antunes, Bruno, Filippi, Renee Zon, Volc, Sahlua, Boldrini, Erica, Menezes, Weder P., Reis, R. M., Camargo, Olavo Pires de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/50210
Resumo: AIM: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. METHODS: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival(OS). RESULTS: Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. CONCLUSION: Loss of MTAP expression is an independent negative prognostic biomarker in ESFT.
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spelling Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumorsBiomarkersESFTEwing sarcoma family of tumorsMethylthioadenosine phosphorylaseMTAPPrognosisCiências Médicas::Medicina BásicaScience & TechnologyAIM: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. METHODS: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival(OS). RESULTS: Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. CONCLUSION: Loss of MTAP expression is an independent negative prognostic biomarker in ESFT.Fundação de Amparo á Pesquisa do Estado de São Paulo (FAPESP) and CNPq grants to RM Reis. WP Menezes is recipient of a FAPESP fellowship (2016/06833–2). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.info:eu-repo/semantics/publishedVersionFuture Medicine LtdUniversidade do MinhoAbrahão-Machado, Lucas FariaAntunes, BrunoFilippi, Renee ZonVolc, SahluaBoldrini, EricaMenezes, Weder P.Reis, R. M.Camargo, Olavo Pires de20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/50210engAbrahao-Machado, L. F., Antunes, B., Filippi, R. Z., Volc, S., et. al. (2018). Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors. Biomarkers in medicine, 12(1), 35-441752-03631752-037110.2217/bmm-2017-015229243509https://www.futuremedicine.com/doi/abs/10.2217/bmm-2017-0152info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-11T01:16:27Zoai:repositorium.sdum.uminho.pt:1822/50210Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:31:14.521996Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
title Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
spellingShingle Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
Abrahão-Machado, Lucas Faria
Biomarkers
ESFT
Ewing sarcoma family of tumors
Methylthioadenosine phosphorylase
MTAP
Prognosis
Ciências Médicas::Medicina Básica
Science & Technology
title_short Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
title_full Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
title_fullStr Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
title_full_unstemmed Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
title_sort Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors
author Abrahão-Machado, Lucas Faria
author_facet Abrahão-Machado, Lucas Faria
Antunes, Bruno
Filippi, Renee Zon
Volc, Sahlua
Boldrini, Erica
Menezes, Weder P.
Reis, R. M.
Camargo, Olavo Pires de
author_role author
author2 Antunes, Bruno
Filippi, Renee Zon
Volc, Sahlua
Boldrini, Erica
Menezes, Weder P.
Reis, R. M.
Camargo, Olavo Pires de
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Abrahão-Machado, Lucas Faria
Antunes, Bruno
Filippi, Renee Zon
Volc, Sahlua
Boldrini, Erica
Menezes, Weder P.
Reis, R. M.
Camargo, Olavo Pires de
dc.subject.por.fl_str_mv Biomarkers
ESFT
Ewing sarcoma family of tumors
Methylthioadenosine phosphorylase
MTAP
Prognosis
Ciências Médicas::Medicina Básica
Science & Technology
topic Biomarkers
ESFT
Ewing sarcoma family of tumors
Methylthioadenosine phosphorylase
MTAP
Prognosis
Ciências Médicas::Medicina Básica
Science & Technology
description AIM: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness and poor outcomes in different types of neoplasms. However, the expression of this biomarker and its biological role in ESFT remain largely unknown. METHODS: Immunohistochemical expression of MTAP was accessed in 112 patients with ESFT in a tissue microarray platform and associated with clinicopathological parameters and overall survival(OS). RESULTS: Loss of MTAP expression was significantly associated with lower OS in both univariate and multivariate analyses. CONCLUSION: Loss of MTAP expression is an independent negative prognostic biomarker in ESFT.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/50210
url https://hdl.handle.net/1822/50210
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Abrahao-Machado, L. F., Antunes, B., Filippi, R. Z., Volc, S., et. al. (2018). Loss of MTAP expression is a negative prognostic marker in Ewing sarcoma family of tumors. Biomarkers in medicine, 12(1), 35-44
1752-0363
1752-0371
10.2217/bmm-2017-0152
29243509
https://www.futuremedicine.com/doi/abs/10.2217/bmm-2017-0152
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Future Medicine Ltd
publisher.none.fl_str_mv Future Medicine Ltd
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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