The choroid plexus as a sex hormone target: Functional implications

Detalhes bibliográficos
Autor(a) principal: Santos, Cecília R.A.
Data de Publicação: 2017
Outros Autores: Duarte, Ana Catarina, Quintela, Telma, Tomás, Joana, Albuquerque, Tânia, Marques, Fernanda, Palha, Joana Almeida, Gonçalves, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/49577
Resumo: The choroid plexuses (CPs) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF). In recent years, novel functions have been attributed to this tissue such as in immune and chemical surveillance of the central nervous system, brain development, adult neurogenesis and circadian rhythm regulation. Sex hormones (SH) are widely recognized as modulators in several neurodegenerative diseases, and there is evidence that estrogens and androgens regulate several fundamental biological functions in the CPs. Therefore, SH are likely to affect the composition of the CSF impacting on brain homeostasis. This review will look at implications of the CPs' sex-related specificities.
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spelling The choroid plexus as a sex hormone target: Functional implicationsChoroid plexusBrain barriersImmune surveillanceCerebrospinal fluidChemical surveillanceSex hormonesCircadian rhythmOlfactory signallingNeurogenesisTaste signallingCiências Médicas::Medicina BásicaScience & TechnologyThe choroid plexuses (CPs) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF). In recent years, novel functions have been attributed to this tissue such as in immune and chemical surveillance of the central nervous system, brain development, adult neurogenesis and circadian rhythm regulation. Sex hormones (SH) are widely recognized as modulators in several neurodegenerative diseases, and there is evidence that estrogens and androgens regulate several fundamental biological functions in the CPs. Therefore, SH are likely to affect the composition of the CSF impacting on brain homeostasis. This review will look at implications of the CPs' sex-related specificities.Portuguese Foundation for Science and Technology (FCT, Portugal – http://www.fct.pt) project grants (PTDC/SAU-NEU/114800/2009); and by FEDER funds through the POCI – COMPETE 2020 – Operational Programme Competitiveness and Internationalisation in Axis I – Strengthening research, technological development and innovation (Project No. 007491) and National Funds by FCT – Foundation for Science and Technology (Project UID/Multi/00709). Joana Tomás was supported by a grant from CENTRO-07-ST24-FEDER-002015. Telma Quintela is a recipient of a FCT fellowship (SFRH/BPD/70781/2010). The work at ICVS/3B’s has the support of Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). Fernanda Marques is a recipient of a FCT Investigator award (IF/00231/2013) of the Fundação para a Ciência e Tecnologia (FCT, Portugal)info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoSantos, Cecília R.A.Duarte, Ana CatarinaQuintela, TelmaTomás, JoanaAlbuquerque, TâniaMarques, FernandaPalha, Joana AlmeidaGonçalves, Isabel2017-01-082017-01-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49577engSantos, C. R., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., ... & Gonçalves, I. (2016). The choroid plexus as a sex hormone target: Functional implications. Frontiers in neuroendocrinology0091-302210.1016/j.yfrne.2016.12.00227998697https://www.sciencedirect.com/science/article/pii/S0091302216300620info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:18:43Zoai:repositorium.sdum.uminho.pt:1822/49577Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:11:34.170881Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The choroid plexus as a sex hormone target: Functional implications
title The choroid plexus as a sex hormone target: Functional implications
spellingShingle The choroid plexus as a sex hormone target: Functional implications
Santos, Cecília R.A.
Choroid plexus
Brain barriers
Immune surveillance
Cerebrospinal fluid
Chemical surveillance
Sex hormones
Circadian rhythm
Olfactory signalling
Neurogenesis
Taste signalling
Ciências Médicas::Medicina Básica
Science & Technology
title_short The choroid plexus as a sex hormone target: Functional implications
title_full The choroid plexus as a sex hormone target: Functional implications
title_fullStr The choroid plexus as a sex hormone target: Functional implications
title_full_unstemmed The choroid plexus as a sex hormone target: Functional implications
title_sort The choroid plexus as a sex hormone target: Functional implications
author Santos, Cecília R.A.
author_facet Santos, Cecília R.A.
Duarte, Ana Catarina
Quintela, Telma
Tomás, Joana
Albuquerque, Tânia
Marques, Fernanda
Palha, Joana Almeida
Gonçalves, Isabel
author_role author
author2 Duarte, Ana Catarina
Quintela, Telma
Tomás, Joana
Albuquerque, Tânia
Marques, Fernanda
Palha, Joana Almeida
Gonçalves, Isabel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Santos, Cecília R.A.
Duarte, Ana Catarina
Quintela, Telma
Tomás, Joana
Albuquerque, Tânia
Marques, Fernanda
Palha, Joana Almeida
Gonçalves, Isabel
dc.subject.por.fl_str_mv Choroid plexus
Brain barriers
Immune surveillance
Cerebrospinal fluid
Chemical surveillance
Sex hormones
Circadian rhythm
Olfactory signalling
Neurogenesis
Taste signalling
Ciências Médicas::Medicina Básica
Science & Technology
topic Choroid plexus
Brain barriers
Immune surveillance
Cerebrospinal fluid
Chemical surveillance
Sex hormones
Circadian rhythm
Olfactory signalling
Neurogenesis
Taste signalling
Ciências Médicas::Medicina Básica
Science & Technology
description The choroid plexuses (CPs) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF). In recent years, novel functions have been attributed to this tissue such as in immune and chemical surveillance of the central nervous system, brain development, adult neurogenesis and circadian rhythm regulation. Sex hormones (SH) are widely recognized as modulators in several neurodegenerative diseases, and there is evidence that estrogens and androgens regulate several fundamental biological functions in the CPs. Therefore, SH are likely to affect the composition of the CSF impacting on brain homeostasis. This review will look at implications of the CPs' sex-related specificities.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-08
2017-01-08T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/49577
url http://hdl.handle.net/1822/49577
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Santos, C. R., Duarte, A. C., Quintela, T., Tomás, J., Albuquerque, T., Marques, F., ... & Gonçalves, I. (2016). The choroid plexus as a sex hormone target: Functional implications. Frontiers in neuroendocrinology
0091-3022
10.1016/j.yfrne.2016.12.002
27998697
https://www.sciencedirect.com/science/article/pii/S0091302216300620
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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