Measuring quality of life of patients with axial spondyloarthritis for economic evaluation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/134131 |
Resumo: | Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Measuring quality of life of patients with axial spondyloarthritis for economic evaluationankylosingeconomicspatient reported outcome measuresspondylitisImmunology and AllergyRheumatologyImmunologyPublisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: To estimate the relationship between EQ5D (three levels, UK version) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) for use in the economic evaluation of health technologies for people with axial spondyloarthritis (axSpA). To compare against the relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). METHODS: An electronic, prospective, Portuguese, nationwide, rheumatic disease register (Reuma.pt) provided data on 1140 patients (5483 observations) with a confirmed diagnosis of axSpA. We estimated models of EQ5D as a function of ASDAS, alone or in combination with measures of functional impairment, using bespoke mixture models which reflect the complex distributional features of EQ5D. The SPondyloArthritis Caught Early cohort provided data from 344 patients (1405 observations) in four European countries and was used for validation. A previously published model of BASDAI/Bath Ankylosing Spondylitis Functional Index (BASFI) was also used to generate predicted EQ5D scores and model performance compared. RESULTS: A non-linear relationship exists between EQ5D from ASDAS. The final model included ASDAS, ASDAS squared, age and age squared and demonstrated close fit in both datasets except where data were sparse for patients with very high levels of disease activity (ASDAS >4). This finding held in the validation dataset. Models that included BASFI improved model fit. The ASDAS based models fit the data marginally less well than models using BASDAI. CONCLUSIONS: Mapping models linking ASDAS to EQ5D allow results from clinical studies to be used in economic evaluation of health technologies with confidence. There is some loss of information compared with BASDAI but this has only a marginal impact.Comprehensive Health Research Centre (CHRC) - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHernandez Alava, MonicaWailoo, AllanChrysanthou, GeorgiosBarcelos, Filipevan Gaalen, Floris A.Santos, HelenaFagerli, Karen MindeGago, LauraMargarida Cunha, Mariavan de Sande, MarleenCouto, Maura C.Bernardes, MiguelRamonda, RobertaExarchou, SofiaCarvalho, Pedro D.van der Heijde, DesiréeMachado, Pedro M.2022-03-08T23:23:02Z2022-02-012022-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/134131eng2044-6055PURE: 41998594https://doi.org/10.1136/rmdopen-2021-001955info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:12:35Zoai:run.unl.pt:10362/134131Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:59.596022Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| title |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| spellingShingle |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation Hernandez Alava, Monica ankylosing economics patient reported outcome measures spondylitis Immunology and Allergy Rheumatology Immunology |
| title_short |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| title_full |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| title_fullStr |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| title_full_unstemmed |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| title_sort |
Measuring quality of life of patients with axial spondyloarthritis for economic evaluation |
| author |
Hernandez Alava, Monica |
| author_facet |
Hernandez Alava, Monica Wailoo, Allan Chrysanthou, Georgios Barcelos, Filipe van Gaalen, Floris A. Santos, Helena Fagerli, Karen Minde Gago, Laura Margarida Cunha, Maria van de Sande, Marleen Couto, Maura C. Bernardes, Miguel Ramonda, Roberta Exarchou, Sofia Carvalho, Pedro D. van der Heijde, Desirée Machado, Pedro M. |
| author_role |
author |
| author2 |
Wailoo, Allan Chrysanthou, Georgios Barcelos, Filipe van Gaalen, Floris A. Santos, Helena Fagerli, Karen Minde Gago, Laura Margarida Cunha, Maria van de Sande, Marleen Couto, Maura C. Bernardes, Miguel Ramonda, Roberta Exarchou, Sofia Carvalho, Pedro D. van der Heijde, Desirée Machado, Pedro M. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Comprehensive Health Research Centre (CHRC) - pólo NMS Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Hernandez Alava, Monica Wailoo, Allan Chrysanthou, Georgios Barcelos, Filipe van Gaalen, Floris A. Santos, Helena Fagerli, Karen Minde Gago, Laura Margarida Cunha, Maria van de Sande, Marleen Couto, Maura C. Bernardes, Miguel Ramonda, Roberta Exarchou, Sofia Carvalho, Pedro D. van der Heijde, Desirée Machado, Pedro M. |
| dc.subject.por.fl_str_mv |
ankylosing economics patient reported outcome measures spondylitis Immunology and Allergy Rheumatology Immunology |
| topic |
ankylosing economics patient reported outcome measures spondylitis Immunology and Allergy Rheumatology Immunology |
| description |
Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03-08T23:23:02Z 2022-02-01 2022-02-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/134131 |
| url |
http://hdl.handle.net/10362/134131 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2044-6055 PURE: 41998594 https://doi.org/10.1136/rmdopen-2021-001955 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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