Metabolism of the Antituberculosis Drug Ethionamide

Detalhes bibliográficos
Autor(a) principal: Nuno Vale
Data de Publicação: 2013
Outros Autores: Paula Gomes, Helder A Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/82041
Resumo: Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. ETH mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. ETH is activated by an EthA enzyme, leading to the formation of an S-oxide metabolite that has considerably better activity than the parent drug. This review comprehensively examines the aspects related with the metabolism of ETH since its discovery up to today.
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spelling Metabolism of the Antituberculosis Drug EthionamideMedicina básicaBasic medicineEthionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. ETH mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. ETH is activated by an EthA enzyme, leading to the formation of an S-oxide metabolite that has considerably better activity than the parent drug. This review comprehensively examines the aspects related with the metabolism of ETH since its discovery up to today.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/82041eng1389-2002Nuno ValePaula GomesHelder A Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T12:45:29Zoai:repositorio-aberto.up.pt:10216/82041Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:26:09.903567Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolism of the Antituberculosis Drug Ethionamide
title Metabolism of the Antituberculosis Drug Ethionamide
spellingShingle Metabolism of the Antituberculosis Drug Ethionamide
Nuno Vale
Medicina básica
Basic medicine
title_short Metabolism of the Antituberculosis Drug Ethionamide
title_full Metabolism of the Antituberculosis Drug Ethionamide
title_fullStr Metabolism of the Antituberculosis Drug Ethionamide
title_full_unstemmed Metabolism of the Antituberculosis Drug Ethionamide
title_sort Metabolism of the Antituberculosis Drug Ethionamide
author Nuno Vale
author_facet Nuno Vale
Paula Gomes
Helder A Santos
author_role author
author2 Paula Gomes
Helder A Santos
author2_role author
author
dc.contributor.author.fl_str_mv Nuno Vale
Paula Gomes
Helder A Santos
dc.subject.por.fl_str_mv Medicina básica
Basic medicine
topic Medicina básica
Basic medicine
description Ethionamide (ETH) is an important second-line antituberculosis drug used for the treatment of patients infected with multidrug-resistant Mycobacterium. Although ETH is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. ETH mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. ETH is activated by an EthA enzyme, leading to the formation of an S-oxide metabolite that has considerably better activity than the parent drug. This review comprehensively examines the aspects related with the metabolism of ETH since its discovery up to today.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/82041
url https://hdl.handle.net/10216/82041
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1389-2002
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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