Circulating endothelial progenitor cells in obese children and adolescents

• Autor(a) principal: Pires, António
• Data de Publicação: 2015
• Outros Autores: Martins, Paula, Paiva, Artur, Pereira, Ana Margarida, Marques, Margarida, Castela, Eduardo, Sena, Cristina M., Seiça, Raquel
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/109176; https://doi.org/10.1016/j.jped.2015.01.011
• topic: Pediatric obesity; C-reactive protein; Monocyte chemoattractant protein-1; E-selectin; Asymmetric dimethylarginine; Endothelial progenitor cells; Obesidade infantil; Proteína C reativa; Proteína quimiotáticade monócitos-1; E-seleticna;; Dimetilarginina assimétrica; Células progenitoras endoteliais; Adolescent; Biomarkers; Blood Pressure; Body Mass Index; Case-Control Studies; Cell Count; Child; Cross-Sectional Studies; Endothelial Progenitor Cells; Female; Humans; Insulin Resistance; Male; Obesity

Objective: This study aimed to investigate the relationship between circulating endothelial progenitor cell count and endothelial activation in a pediatric population with obesity. Methods: Observational and transversal study, including 120 children and adolescents with primary obesity of both sexes, aged 6---17 years, who were recruited at this Cardiovascular Risk Clinic. The control group was made up of 41 children and adolescents with normal body mass index. The variables analyzed were: age, gender, body mass index, systolic and diastolic blood pressure, high-sensitivity C-reactive protein, lipid profile, leptin, adiponectin, homeostasis model assessment-insulin resistance, monocyte chemoattractant protein-1, E-selectin, asymmetric dimethylarginine and circulating progenitor endothelial cell count. Results: Insulin resistance was correlated to asymmetric dimethylarginine ( = 0.340; p = 0.003),which was directly, but weakly correlated to E-selectin ( = 0.252; p = 0.046). High sensitiv-ity C-reactive protein was not found to be correlated to markers of endothelial activation.Systolic blood pressure was directly correlated to body mass index ( = 0.471; p < 0.001) andthe homeostasis model assessment-insulin resistance ( = 0.230; p = 0.012), and inversely corre-lated to adiponectin ( = −0.331; p < 0.001) and high-density lipoprotein cholesterol ( = −0.319;p < 0.001). Circulating endothelial progenitor cell count was directly, but weakly correlated, tobody mass index (r = 0.211; p = 0.016), leptin ( = 0.245; p = 0.006), triglyceride levels (r = 0.241;p = 0.031), and E-selectin ( = 0.297; p = 0.004).Conclusion: Circulating endothelial progenitor cell count is elevated in obese children and ado-lescents with evidence of endothelial activation, suggesting that, during infancy, endothelialrepairing mechanisms are present in the context of endothelial activation.