Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene

Detalhes bibliográficos
Autor(a) principal: Salgado, Helena
Data de Publicação: 2022
Outros Autores: Gomes, Ana T. P. C., Duarte, Ana S., Ferreira, José M. F., Fernandes, Carlos, Figueiral, Maria Helena, Mesquita, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/39181
Resumo: The present study aimed to test, in vitro, the antimicrobial activity against Candida albicans and Streptococcus mutans and the surface roughness of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene. A 3D-printed polymethylmethacrylate dental resin was reinforced with four different concentrations of graphene: 0.01, 0.1, 0.25 and 0.5 wt%. Neat resin was used as a control. The specimens were printed in a liquid crystal display printer. Disc specimens were used in antimicrobial evaluation, and bar-shaped specimens were used to measure surface roughness. The study of antimicrobial activity included the inhibition of the growth of C. albicans and S. mutans and their adhesion to the resin’s surface. Surface roughness increased with the increase in the graphene concentration. The growth inhibition of C. albicans was observed in the different concentrations of graphene after 24 h, with no recovery after 48 h. The specimens doped with graphene were capable of inactivating S. mutans after 48 h. The surface-adhesion studies showed that the density of microbial biofilms decreases in the case of specimens doped with graphene. Graphene, despite increasing the resin’s surface roughness, was effective in inhibiting the growth and the adhesion to the resin’s surface of the main inducers of prosthetic stomatitis.
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spelling Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphenePolymethyl methacrylateGrapheneCandida albicansStreptococcus mutansDenture stomatitis3D printingThe present study aimed to test, in vitro, the antimicrobial activity against Candida albicans and Streptococcus mutans and the surface roughness of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene. A 3D-printed polymethylmethacrylate dental resin was reinforced with four different concentrations of graphene: 0.01, 0.1, 0.25 and 0.5 wt%. Neat resin was used as a control. The specimens were printed in a liquid crystal display printer. Disc specimens were used in antimicrobial evaluation, and bar-shaped specimens were used to measure surface roughness. The study of antimicrobial activity included the inhibition of the growth of C. albicans and S. mutans and their adhesion to the resin’s surface. Surface roughness increased with the increase in the graphene concentration. The growth inhibition of C. albicans was observed in the different concentrations of graphene after 24 h, with no recovery after 48 h. The specimens doped with graphene were capable of inactivating S. mutans after 48 h. The surface-adhesion studies showed that the density of microbial biofilms decreases in the case of specimens doped with graphene. Graphene, despite increasing the resin’s surface roughness, was effective in inhibiting the growth and the adhesion to the resin’s surface of the main inducers of prosthetic stomatitis.Veritati - Repositório Institucional da Universidade Católica PortuguesaSalgado, HelenaGomes, Ana T. P. C.Duarte, Ana S.Ferreira, José M. F.Fernandes, CarlosFigueiral, Maria HelenaMesquita, Pedro2022-10-26T08:19:47Z2022-10-172022-10-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/39181eng2227-905910.3390/biomedicines1010260785140651761PMC959947336289869000872187100001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-16T01:45:01Zoai:repositorio.ucp.pt:10400.14/39181Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:32:01.618971Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
title Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
spellingShingle Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
Salgado, Helena
Polymethyl methacrylate
Graphene
Candida albicans
Streptococcus mutans
Denture stomatitis
3D printing
title_short Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
title_full Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
title_fullStr Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
title_full_unstemmed Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
title_sort Antimicrobial activity of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene
author Salgado, Helena
author_facet Salgado, Helena
Gomes, Ana T. P. C.
Duarte, Ana S.
Ferreira, José M. F.
Fernandes, Carlos
Figueiral, Maria Helena
Mesquita, Pedro
author_role author
author2 Gomes, Ana T. P. C.
Duarte, Ana S.
Ferreira, José M. F.
Fernandes, Carlos
Figueiral, Maria Helena
Mesquita, Pedro
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Salgado, Helena
Gomes, Ana T. P. C.
Duarte, Ana S.
Ferreira, José M. F.
Fernandes, Carlos
Figueiral, Maria Helena
Mesquita, Pedro
dc.subject.por.fl_str_mv Polymethyl methacrylate
Graphene
Candida albicans
Streptococcus mutans
Denture stomatitis
3D printing
topic Polymethyl methacrylate
Graphene
Candida albicans
Streptococcus mutans
Denture stomatitis
3D printing
description The present study aimed to test, in vitro, the antimicrobial activity against Candida albicans and Streptococcus mutans and the surface roughness of a 3D-printed polymethylmethacrylate dental resin enhanced with graphene. A 3D-printed polymethylmethacrylate dental resin was reinforced with four different concentrations of graphene: 0.01, 0.1, 0.25 and 0.5 wt%. Neat resin was used as a control. The specimens were printed in a liquid crystal display printer. Disc specimens were used in antimicrobial evaluation, and bar-shaped specimens were used to measure surface roughness. The study of antimicrobial activity included the inhibition of the growth of C. albicans and S. mutans and their adhesion to the resin’s surface. Surface roughness increased with the increase in the graphene concentration. The growth inhibition of C. albicans was observed in the different concentrations of graphene after 24 h, with no recovery after 48 h. The specimens doped with graphene were capable of inactivating S. mutans after 48 h. The surface-adhesion studies showed that the density of microbial biofilms decreases in the case of specimens doped with graphene. Graphene, despite increasing the resin’s surface roughness, was effective in inhibiting the growth and the adhesion to the resin’s surface of the main inducers of prosthetic stomatitis.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-26T08:19:47Z
2022-10-17
2022-10-17T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/39181
url http://hdl.handle.net/10400.14/39181
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2227-9059
10.3390/biomedicines10102607
85140651761
PMC9599473
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