Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/18641 |
Resumo: | Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study.The sulphorhodamine B(SRB)assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasisis put on the secretion of Abax parallelepipedus,which showed the highest anti tumour potential and weakest inhibition of non-tumour cell proliferation.The anti tumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time.It is suggested that certain organic acids are responsible for the action.Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)Antiproliferative effectCell linesEllipticineGround beetlesPygidial gland secretionsInhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study.The sulphorhodamine B(SRB)assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasisis put on the secretion of Abax parallelepipedus,which showed the highest anti tumour potential and weakest inhibition of non-tumour cell proliferation.The anti tumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time.It is suggested that certain organic acids are responsible for the action.Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity.The study was financially supported by the Serbian Ministry of Education, Science, and Technological Development (Grants Nos. 173038 and 173032) and the Foundation for Science and Technology (FCT, Portugal) (Grant No. SFRH/BPD/68344/2010).Biblioteca Digital do IPBNenadić, M.Soković, MarinaCalhelha, Ricardo C.Ferreira, Isabel C.F.R.Ćirić, AnaVesović, NikolaĆurčić, Srećko2018-01-19T10:00:00Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/18641engNenadić, M.; Soković, M; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Ćirić, Ana; Vesović, Nikola; Ćurčić, Srećko (2018). Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae). Biologia. ISSN 0006-3088. 73, p. 787-7920006-308810.2478/s11756-018-0082-x1336-9563info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:42:50Zoai:bibliotecadigital.ipb.pt:10198/18641Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:09:02.386396Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
title |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
spellingShingle |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) Nenadić, M. Antiproliferative effect Cell lines Ellipticine Ground beetles Pygidial gland secretions |
title_short |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
title_full |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
title_fullStr |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
title_full_unstemmed |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
title_sort |
Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae) |
author |
Nenadić, M. |
author_facet |
Nenadić, M. Soković, Marina Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Ćirić, Ana Vesović, Nikola Ćurčić, Srećko |
author_role |
author |
author2 |
Soković, Marina Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Ćirić, Ana Vesović, Nikola Ćurčić, Srećko |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Nenadić, M. Soković, Marina Calhelha, Ricardo C. Ferreira, Isabel C.F.R. Ćirić, Ana Vesović, Nikola Ćurčić, Srećko |
dc.subject.por.fl_str_mv |
Antiproliferative effect Cell lines Ellipticine Ground beetles Pygidial gland secretions |
topic |
Antiproliferative effect Cell lines Ellipticine Ground beetles Pygidial gland secretions |
description |
Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study.The sulphorhodamine B(SRB)assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasisis put on the secretion of Abax parallelepipedus,which showed the highest anti tumour potential and weakest inhibition of non-tumour cell proliferation.The anti tumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time.It is suggested that certain organic acids are responsible for the action.Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/18641 |
url |
http://hdl.handle.net/10198/18641 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nenadić, M.; Soković, M; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Ćirić, Ana; Vesović, Nikola; Ćurčić, Srećko (2018). Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae). Biologia. ISSN 0006-3088. 73, p. 787-792 0006-3088 10.2478/s11756-018-0082-x 1336-9563 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135350791077888 |