Inhibition of tumour and non-tumour cell proliferation by pygidial gland secretions of four ground beetle species (Coleoptera: Carabidae)

• Autor(a) principal: Nenadić, M.
• Data de Publicação: 2018
• Outros Autores: Soković, Marina, Calhelha, Ricardo C., Ferreira, Isabel C.F.R., Ćirić, Ana, Vesović, Nikola, Ćurčić, Srećko
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10198/18641
• topic: Antiproliferative effect; Cell lines; Ellipticine; Ground beetles; Pygidial gland secretions

Inhibition of the proliferation of human tumour cells and porcine non-tumour cells by the pygidial gland secretion released by adults of four ground beetle species was observed in this study.The sulphorhodamine B(SRB)assay was applied to establish the percentages of inhibition of the net growth of four human tumour cell lines and porcine liver primary non-tumour cells. The secretions of all tested ground beetle species were shown to have an antiproliferative effect on the tested cell lines. Special emphasisis put on the secretion of Abax parallelepipedus,which showed the highest anti tumour potential and weakest inhibition of non-tumour cell proliferation.The anti tumour and antiproliferative potential of the pygidial gland secretions of ground beetles is here demonstrated for the first time.It is suggested that certain organic acids are responsible for the action.Further investigation needs to be conducted in order to better understand the mechanisms governing the observed cytotoxic and antitumour activity.