HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/45417 https://doi.org/10.1586/14737167.2013.847366 |
Resumo: | Introduction. Short stature may be associated with impairments in health-related quality of life (HrQoL). This study compares the HrQoL of children/adolescents diagnosed with short stature to population norms and examined the effects of height deviation and treatment status on HrQoL. Method. We cross-sectionally assessed 110 children/adolescents aged 8-18, with current short stature (height deviation equal to or below -2 SD) or normal height achieved since diagnosis, and 98 parents, using the generic KIDSCREEN and the chronic-generic DISABKIDS instruments. Results. Generic HrQoL of patients was similar to population norms. Patients with achieved normal height reported better chronic-generic HrQoL when untreated, while patients with current short stature reported better HrQoL when receiving treatment. Parents reported better HrQoL for treated patients, especially for girls. Conclusion. Although their HrQoL is not significantly compromised, patients diagnosed with short stature may profit from growth-hormone treatment. Specific instruments are needed to adequately assess the effectiveness of treatment. |
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HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instrumentsShort statureChildren and adolescentsGrowth-hormone treatmentHealth-related quality of lifePatient- and proxy-reported outcomesIntroduction. Short stature may be associated with impairments in health-related quality of life (HrQoL). This study compares the HrQoL of children/adolescents diagnosed with short stature to population norms and examined the effects of height deviation and treatment status on HrQoL. Method. We cross-sectionally assessed 110 children/adolescents aged 8-18, with current short stature (height deviation equal to or below -2 SD) or normal height achieved since diagnosis, and 98 parents, using the generic KIDSCREEN and the chronic-generic DISABKIDS instruments. Results. Generic HrQoL of patients was similar to population norms. Patients with achieved normal height reported better chronic-generic HrQoL when untreated, while patients with current short stature reported better HrQoL when receiving treatment. Parents reported better HrQoL for treated patients, especially for girls. Conclusion. Although their HrQoL is not significantly compromised, patients diagnosed with short stature may profit from growth-hormone treatment. Specific instruments are needed to adequately assess the effectiveness of treatment.The development of the QoLISSY questionnaire was funded through a research grant by Pfizer Ltd. MB has received honoraria and acted as consultant. AP and HW (members of the QoLISSY group) are Pfizer Employees. All other authors have no involvement with Pfizer ltd. nor have financial interests. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. NS was supported by a PhD Grant from the Portuguese Foundation for Science and Technology (SFRH/BD/69885/2010).2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/45417http://hdl.handle.net/10316/45417https://doi.org/10.1586/14737167.2013.847366engSilva, N., Bullinger, M., Quitmann, J., Ravens-Sieberer, U., Rohenkohl, A., & The QoLISSY Group (2013). Health-related quality of life of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments. Expert Review of Pharmacoeconomics & Outcomes Research, 13(6), 817-827. doi:10.1586/14737167.2013.847366http://www.tandfonline.com/doi/abs/10.1586/14737167.2013.847366?journalCode=ierp20Silva, NeuzaBullinger, MonikaQuitmann, JuliaRavens-Sieberer, UlrikeRohenkohl, Anjainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-06-29T10:03:34Zoai:estudogeral.uc.pt:10316/45417Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:48:31.418094Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
title |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
spellingShingle |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments Silva, Neuza Short stature Children and adolescents Growth-hormone treatment Health-related quality of life Patient- and proxy-reported outcomes |
title_short |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
title_full |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
title_fullStr |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
title_full_unstemmed |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
title_sort |
HRQoL of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments |
author |
Silva, Neuza |
author_facet |
Silva, Neuza Bullinger, Monika Quitmann, Julia Ravens-Sieberer, Ulrike Rohenkohl, Anja |
author_role |
author |
author2 |
Bullinger, Monika Quitmann, Julia Ravens-Sieberer, Ulrike Rohenkohl, Anja |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Neuza Bullinger, Monika Quitmann, Julia Ravens-Sieberer, Ulrike Rohenkohl, Anja |
dc.subject.por.fl_str_mv |
Short stature Children and adolescents Growth-hormone treatment Health-related quality of life Patient- and proxy-reported outcomes |
topic |
Short stature Children and adolescents Growth-hormone treatment Health-related quality of life Patient- and proxy-reported outcomes |
description |
Introduction. Short stature may be associated with impairments in health-related quality of life (HrQoL). This study compares the HrQoL of children/adolescents diagnosed with short stature to population norms and examined the effects of height deviation and treatment status on HrQoL. Method. We cross-sectionally assessed 110 children/adolescents aged 8-18, with current short stature (height deviation equal to or below -2 SD) or normal height achieved since diagnosis, and 98 parents, using the generic KIDSCREEN and the chronic-generic DISABKIDS instruments. Results. Generic HrQoL of patients was similar to population norms. Patients with achieved normal height reported better chronic-generic HrQoL when untreated, while patients with current short stature reported better HrQoL when receiving treatment. Parents reported better HrQoL for treated patients, especially for girls. Conclusion. Although their HrQoL is not significantly compromised, patients diagnosed with short stature may profit from growth-hormone treatment. Specific instruments are needed to adequately assess the effectiveness of treatment. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/45417 http://hdl.handle.net/10316/45417 https://doi.org/10.1586/14737167.2013.847366 |
url |
http://hdl.handle.net/10316/45417 https://doi.org/10.1586/14737167.2013.847366 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Silva, N., Bullinger, M., Quitmann, J., Ravens-Sieberer, U., Rohenkohl, A., & The QoLISSY Group (2013). Health-related quality of life of European children and adolescents with short stature as assessed with generic (KIDSCREEN) and chronic-generic (DISABKIDS) instruments. Expert Review of Pharmacoeconomics & Outcomes Research, 13(6), 817-827. doi:10.1586/14737167.2013.847366 http://www.tandfonline.com/doi/abs/10.1586/14737167.2013.847366?journalCode=ierp20 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133763795419136 |