Hepatitis E Virus in the Iberian Peninsula: A Systematic Review

Detalhes bibliográficos
Autor(a) principal: Santos-Silva, S
Data de Publicação: 2023
Outros Autores: Moraes, DFDD, López-López, P, Rivero-Juarez, A, Mesquita, JR, Nascimento, MSJ
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/154205
Resumo: One of the most frequent causes of acute viral hepatitis is hepatitis E virus (HEV) causing 20 million infections worldwide each year and 44,000 deaths. Studies on HEV in the Iberian Peninsula have been increasing through time with HEV infection being identified in humans and animals. The aim of the present systematic review was to compile and evaluate all the published data on HEV from studies performed in humans, animals and environmental samples in the Iberian Peninsula. The electronic databases Mendeley, PubMed, Scopus, and Web of Science were thoroughly searched, and research published up until February 01, 2023 were included. Resulting in a total of 151 eligible papers by full reading and application of PRISMA exclusion/inclusion criteria. Overall, the present review shows that several HEV genotypes, namely HEV-1, 3, 4, and 6 as well as Rocahepevirus, are circulating in humans, animals, and in the environment in the Iberian Peninsula. HEV-3 was the most common genotype circulating in humans in Portugal and Spain, as expected for developed countries, with HEV-1 only being detected in travelers and emigrants from HEV endemic regions. Spain is the biggest pork producer in Europe and given the high circulation of HEV in pigs, with HEV-3 being primarily associated to zoonotic transmission through consumption of swine meat and meat products, in our opinion, the introduction of an HEV surveillance system in swine and inclusion of HEV in diagnostic routines for acute and chronic human hepatitis would be important. Additionally, we propose that establishing a monitoring mechanism for HEV is crucial in order to gain a comprehensive understanding of the prevalence of this illness and the various strains present in the Iberian Peninsula, as well as their potential impact on public health.
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spelling Hepatitis E Virus in the Iberian Peninsula: A Systematic ReviewHepatitis E virusIberian PeninsulaZoonoticInfectionSystematic reviewOne of the most frequent causes of acute viral hepatitis is hepatitis E virus (HEV) causing 20 million infections worldwide each year and 44,000 deaths. Studies on HEV in the Iberian Peninsula have been increasing through time with HEV infection being identified in humans and animals. The aim of the present systematic review was to compile and evaluate all the published data on HEV from studies performed in humans, animals and environmental samples in the Iberian Peninsula. The electronic databases Mendeley, PubMed, Scopus, and Web of Science were thoroughly searched, and research published up until February 01, 2023 were included. Resulting in a total of 151 eligible papers by full reading and application of PRISMA exclusion/inclusion criteria. Overall, the present review shows that several HEV genotypes, namely HEV-1, 3, 4, and 6 as well as Rocahepevirus, are circulating in humans, animals, and in the environment in the Iberian Peninsula. HEV-3 was the most common genotype circulating in humans in Portugal and Spain, as expected for developed countries, with HEV-1 only being detected in travelers and emigrants from HEV endemic regions. Spain is the biggest pork producer in Europe and given the high circulation of HEV in pigs, with HEV-3 being primarily associated to zoonotic transmission through consumption of swine meat and meat products, in our opinion, the introduction of an HEV surveillance system in swine and inclusion of HEV in diagnostic routines for acute and chronic human hepatitis would be important. Additionally, we propose that establishing a monitoring mechanism for HEV is crucial in order to gain a comprehensive understanding of the prevalence of this illness and the various strains present in the Iberian Peninsula, as well as their potential impact on public health.Springer20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/154205eng1867-03341867-034210.1007/s12560-023-09560-5Santos-Silva, SMoraes, DFDDLópez-López, PRivero-Juarez, AMesquita, JRNascimento, MSJinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:55:08Zoai:repositorio-aberto.up.pt:10216/154205Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:35:17.453175Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
title Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
spellingShingle Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
Santos-Silva, S
Hepatitis E virus
Iberian Peninsula
Zoonotic
Infection
Systematic review
title_short Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
title_full Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
title_fullStr Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
title_full_unstemmed Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
title_sort Hepatitis E Virus in the Iberian Peninsula: A Systematic Review
author Santos-Silva, S
author_facet Santos-Silva, S
Moraes, DFDD
López-López, P
Rivero-Juarez, A
Mesquita, JR
Nascimento, MSJ
author_role author
author2 Moraes, DFDD
López-López, P
Rivero-Juarez, A
Mesquita, JR
Nascimento, MSJ
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santos-Silva, S
Moraes, DFDD
López-López, P
Rivero-Juarez, A
Mesquita, JR
Nascimento, MSJ
dc.subject.por.fl_str_mv Hepatitis E virus
Iberian Peninsula
Zoonotic
Infection
Systematic review
topic Hepatitis E virus
Iberian Peninsula
Zoonotic
Infection
Systematic review
description One of the most frequent causes of acute viral hepatitis is hepatitis E virus (HEV) causing 20 million infections worldwide each year and 44,000 deaths. Studies on HEV in the Iberian Peninsula have been increasing through time with HEV infection being identified in humans and animals. The aim of the present systematic review was to compile and evaluate all the published data on HEV from studies performed in humans, animals and environmental samples in the Iberian Peninsula. The electronic databases Mendeley, PubMed, Scopus, and Web of Science were thoroughly searched, and research published up until February 01, 2023 were included. Resulting in a total of 151 eligible papers by full reading and application of PRISMA exclusion/inclusion criteria. Overall, the present review shows that several HEV genotypes, namely HEV-1, 3, 4, and 6 as well as Rocahepevirus, are circulating in humans, animals, and in the environment in the Iberian Peninsula. HEV-3 was the most common genotype circulating in humans in Portugal and Spain, as expected for developed countries, with HEV-1 only being detected in travelers and emigrants from HEV endemic regions. Spain is the biggest pork producer in Europe and given the high circulation of HEV in pigs, with HEV-3 being primarily associated to zoonotic transmission through consumption of swine meat and meat products, in our opinion, the introduction of an HEV surveillance system in swine and inclusion of HEV in diagnostic routines for acute and chronic human hepatitis would be important. Additionally, we propose that establishing a monitoring mechanism for HEV is crucial in order to gain a comprehensive understanding of the prevalence of this illness and the various strains present in the Iberian Peninsula, as well as their potential impact on public health.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
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1867-0342
10.1007/s12560-023-09560-5
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