Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate

Detalhes bibliográficos
Autor(a) principal: Simões, Tiago
Data de Publicação: 2019
Outros Autores: Novais, Sara C., Natal-da-Luz, Tiago, Devreese, Bart, de Boer, Tjalf, Roelofs, Dick, Sousa, José P., Van Straalen, Nico M., Lemos, Marco F. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/4190
Resumo: This work was supported by FCT through the projects UID/MAR/ 04292/2013, ENVIRONOME (PTDC/AGR-PRO/3496/2012 - POCI-01-0145-FEDER-016773), and grants awarded to TS (SFRH/BD/98266/ 2013), SN (SFRH/BPD/94500/2013), and TNL (SFRH/BPD/110943/ 2015). Project was also partially funded by the Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER000018) cofunded by Centro 2020 program, Portugal2020, European Union, through the European Regional Development Fund. DR was also supported by EU FP7 Sustainable Nanotechnologies project (SUN, grant number 604305).
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spelling Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrateCollembolanEnvironmentFungicidesOmicsSoilThis work was supported by FCT through the projects UID/MAR/ 04292/2013, ENVIRONOME (PTDC/AGR-PRO/3496/2012 - POCI-01-0145-FEDER-016773), and grants awarded to TS (SFRH/BD/98266/ 2013), SN (SFRH/BPD/94500/2013), and TNL (SFRH/BPD/110943/ 2015). Project was also partially funded by the Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER000018) cofunded by Centro 2020 program, Portugal2020, European Union, through the European Regional Development Fund. DR was also supported by EU FP7 Sustainable Nanotechnologies project (SUN, grant number 604305).The use of an integrative molecular approach can actively improve the evaluation of environmental health status and impact of chemicals, providing the knowledge to develop sentinel tools that can be integrated in risk assessment studies, since gene and protein expressions represent the first response barriers to anthropogenic stress. This work aimed to determine the mechanisms of toxic action of a widely applied fungicide formulation (chlorothalonil), following a time series approach and using a soil model arthropod, Folsomia candida. To link effects at different levels of biological organization, data were collected on reproduction, gene expression and protein levels, in a time series during exposure to a natural soil. Results showed a mechanistic mode of action for chlorothalonil, affecting pathways of detoxification and excretion, immune response, cellular respiration, protein metabolism and oxidative stress defense, causing irregular cell signaling (JNK and NOD ½ pathways), DNA damage and abnormal cell proliferation, leading to impairment in developmental features such as molting cycle and reproduction. The omics datasets presented highly significant positive correlations between the gene expression levels at a certain time-point and the corresponding protein products 2e3 days later. The integrated omics in this study has provided useful insights into pesticide mechanisms of toxicity, evidencing the relevance of such analyses in toxicological studies, and highlighting the importance of considering a time-series when integrating these datasets.IC-OnlineSimões, TiagoNovais, Sara C.Natal-da-Luz, TiagoDevreese, Bartde Boer, TjalfRoelofs, DickSousa, José P.Van Straalen, Nico M.Lemos, Marco F. L.2019-10-11T14:38:55Z2019-022019-10-07T10:45:52Z2019-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/4190engSimões, T., Novais, S. C., Lemos, M. F. L., Natal-da-Luz, T., Sousa, J. P., de Boer, T., … Devreese, B. (2019). Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate. Environmental Pollution, 246, 845–854. https://doi.org/10.1016/j.envpol.2018.12.0690269-7491cv-prod-14301710.1016/j.envpol.2018.12.069metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:48:49Zoai:iconline.ipleiria.pt:10400.8/4190Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:48:07.636191Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
title Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
spellingShingle Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
Simões, Tiago
Collembolan
Environment
Fungicides
Omics
Soil
title_short Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
title_full Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
title_fullStr Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
title_full_unstemmed Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
title_sort Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate
author Simões, Tiago
author_facet Simões, Tiago
Novais, Sara C.
Natal-da-Luz, Tiago
Devreese, Bart
de Boer, Tjalf
Roelofs, Dick
Sousa, José P.
Van Straalen, Nico M.
Lemos, Marco F. L.
author_role author
author2 Novais, Sara C.
Natal-da-Luz, Tiago
Devreese, Bart
de Boer, Tjalf
Roelofs, Dick
Sousa, José P.
Van Straalen, Nico M.
Lemos, Marco F. L.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Simões, Tiago
Novais, Sara C.
Natal-da-Luz, Tiago
Devreese, Bart
de Boer, Tjalf
Roelofs, Dick
Sousa, José P.
Van Straalen, Nico M.
Lemos, Marco F. L.
dc.subject.por.fl_str_mv Collembolan
Environment
Fungicides
Omics
Soil
topic Collembolan
Environment
Fungicides
Omics
Soil
description This work was supported by FCT through the projects UID/MAR/ 04292/2013, ENVIRONOME (PTDC/AGR-PRO/3496/2012 - POCI-01-0145-FEDER-016773), and grants awarded to TS (SFRH/BD/98266/ 2013), SN (SFRH/BPD/94500/2013), and TNL (SFRH/BPD/110943/ 2015). Project was also partially funded by the Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER000018) cofunded by Centro 2020 program, Portugal2020, European Union, through the European Regional Development Fund. DR was also supported by EU FP7 Sustainable Nanotechnologies project (SUN, grant number 604305).
publishDate 2019
dc.date.none.fl_str_mv 2019-10-11T14:38:55Z
2019-02
2019-10-07T10:45:52Z
2019-02-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/4190
url http://hdl.handle.net/10400.8/4190
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Simões, T., Novais, S. C., Lemos, M. F. L., Natal-da-Luz, T., Sousa, J. P., de Boer, T., … Devreese, B. (2019). Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate. Environmental Pollution, 246, 845–854. https://doi.org/10.1016/j.envpol.2018.12.069
0269-7491
cv-prod-143017
10.1016/j.envpol.2018.12.069
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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