Current challenges and future opportunities of phage therapy
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/68693 |
Resumo: | Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy. |
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Current challenges and future opportunities of phage therapyClinical trialsphage resistancephage engineeringphage cocktailsregulatory frameworkOne-HealthScience & TechnologyAntibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the project PTDC/BBB-BSS/6471/2014 ( POCI-01–0145-FEDER-016643); the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01–0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. DPP and GP are supported by FCT through the grants SFRH/BPD/116187/2016 and SFRH/BD/117365/2016, respectively.info:eu-repo/semantics/publishedVersionOxford University PressUniversidade do MinhoPires, Diana P.Costa, Ana RitaPinto, GraçaMeneses, LucianaAzeredo, Joana2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68693engPires, Diana P.; Costa, Ana Rita; Pinto, Graça; Meneses, Luciana; Azeredo, Joana, Current challenges and future opportunities of phage therapy. FEMS Microbiology Reviews, 44(6), 684-700, 20200168-644510.1093/femsre/fuaa01732472938https://academic.oup.com/femsreinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:46Zoai:repositorium.sdum.uminho.pt:1822/68693Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:46.131699Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Current challenges and future opportunities of phage therapy |
title |
Current challenges and future opportunities of phage therapy |
spellingShingle |
Current challenges and future opportunities of phage therapy Pires, Diana P. Clinical trials phage resistance phage engineering phage cocktails regulatory framework One-Health Science & Technology |
title_short |
Current challenges and future opportunities of phage therapy |
title_full |
Current challenges and future opportunities of phage therapy |
title_fullStr |
Current challenges and future opportunities of phage therapy |
title_full_unstemmed |
Current challenges and future opportunities of phage therapy |
title_sort |
Current challenges and future opportunities of phage therapy |
author |
Pires, Diana P. |
author_facet |
Pires, Diana P. Costa, Ana Rita Pinto, Graça Meneses, Luciana Azeredo, Joana |
author_role |
author |
author2 |
Costa, Ana Rita Pinto, Graça Meneses, Luciana Azeredo, Joana |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pires, Diana P. Costa, Ana Rita Pinto, Graça Meneses, Luciana Azeredo, Joana |
dc.subject.por.fl_str_mv |
Clinical trials phage resistance phage engineering phage cocktails regulatory framework One-Health Science & Technology |
topic |
Clinical trials phage resistance phage engineering phage cocktails regulatory framework One-Health Science & Technology |
description |
Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11 2020-11-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/68693 |
url |
http://hdl.handle.net/1822/68693 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pires, Diana P.; Costa, Ana Rita; Pinto, Graça; Meneses, Luciana; Azeredo, Joana, Current challenges and future opportunities of phage therapy. FEMS Microbiology Reviews, 44(6), 684-700, 2020 0168-6445 10.1093/femsre/fuaa017 32472938 https://academic.oup.com/femsre |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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