Current challenges and future opportunities of phage therapy

Detalhes bibliográficos
Autor(a) principal: Pires, Diana P.
Data de Publicação: 2020
Outros Autores: Costa, Ana Rita, Pinto, Graça, Meneses, Luciana, Azeredo, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/68693
Resumo: Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy.
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spelling Current challenges and future opportunities of phage therapyClinical trialsphage resistancephage engineeringphage cocktailsregulatory frameworkOne-HealthScience & TechnologyAntibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the project PTDC/BBB-BSS/6471/2014 ( POCI-01–0145-FEDER-016643); the strategic funding of UIDB/04469/2020 unit and BioTecNorte operation (NORTE-01–0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020–Programa Operacional Regional do Norte. DPP and GP are supported by FCT through the grants SFRH/BPD/116187/2016 and SFRH/BD/117365/2016, respectively.info:eu-repo/semantics/publishedVersionOxford University PressUniversidade do MinhoPires, Diana P.Costa, Ana RitaPinto, GraçaMeneses, LucianaAzeredo, Joana2020-112020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/68693engPires, Diana P.; Costa, Ana Rita; Pinto, Graça; Meneses, Luciana; Azeredo, Joana, Current challenges and future opportunities of phage therapy. FEMS Microbiology Reviews, 44(6), 684-700, 20200168-644510.1093/femsre/fuaa01732472938https://academic.oup.com/femsreinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:46Zoai:repositorium.sdum.uminho.pt:1822/68693Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:46.131699Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Current challenges and future opportunities of phage therapy
title Current challenges and future opportunities of phage therapy
spellingShingle Current challenges and future opportunities of phage therapy
Pires, Diana P.
Clinical trials
phage resistance
phage engineering
phage cocktails
regulatory framework
One-Health
Science & Technology
title_short Current challenges and future opportunities of phage therapy
title_full Current challenges and future opportunities of phage therapy
title_fullStr Current challenges and future opportunities of phage therapy
title_full_unstemmed Current challenges and future opportunities of phage therapy
title_sort Current challenges and future opportunities of phage therapy
author Pires, Diana P.
author_facet Pires, Diana P.
Costa, Ana Rita
Pinto, Graça
Meneses, Luciana
Azeredo, Joana
author_role author
author2 Costa, Ana Rita
Pinto, Graça
Meneses, Luciana
Azeredo, Joana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pires, Diana P.
Costa, Ana Rita
Pinto, Graça
Meneses, Luciana
Azeredo, Joana
dc.subject.por.fl_str_mv Clinical trials
phage resistance
phage engineering
phage cocktails
regulatory framework
One-Health
Science & Technology
topic Clinical trials
phage resistance
phage engineering
phage cocktails
regulatory framework
One-Health
Science & Technology
description Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
2020-11-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/68693
url http://hdl.handle.net/1822/68693
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pires, Diana P.; Costa, Ana Rita; Pinto, Graça; Meneses, Luciana; Azeredo, Joana, Current challenges and future opportunities of phage therapy. FEMS Microbiology Reviews, 44(6), 684-700, 2020
0168-6445
10.1093/femsre/fuaa017
32472938
https://academic.oup.com/femsre
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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