European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/6499 |
Resumo: | Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered. |
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European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?MortalityVDMB/YamagataB/YamagataEuroMOMOFluMOMOInfluenzaMortalityMortalidadeEuroMOMOFluMOMOInfluenzaEstados de Saúde e de DoençaObjectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered.Elsevier/ on behalf of European Society of Clinical Microbiology and Infectious DiseasesRepositório Científico do Instituto Nacional de SaúdeNielsen, JensVestergaard, LasseRichter, L.Schmid, D.Bustos, N.Asikainen, T.Trebbien, R.Denissov, G.Innos, K.Virtanen, M.J.Fouillet, A.Lytras, T.Gkolfinopoulou, K.Heiden, M. an derGrabenhenrich, L.Uphoff, H.Paldy, A.Bobvos, J.Domegan, L.O'Donnell, J.Scortichini, M.de Martino, A.Mossong, J.England, K.Melillo, J.van Asten, L.de Lange, M. MATønnessen, R.White, R.A.Silva, Susana PereiraRodrigues, Ana PaulaLarrauri, AmparoMazagatos, ClaraFarah, A.Carnahan, A.D.Junker, C.Sinnathamby, M.Pebody, R.G.Andrews, N.Reynolds, A.McMenamin, J.Brown, C.S.Adlhoch, C.Penttinen, P.Mølbak, K.Krause, T.G.2020-04-23T16:37:35Z2019-02-182019-02-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6499engClin Microbiol Infect. 2019 Oct;25(10):1266-1276. doi: 10.1016/j.cmi.2019.02.011. Epub 2019 Feb 181198-743X10.1016/j.cmi.2019.02.011info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:26Zoai:repositorio.insa.pt:10400.18/6499Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:07.237180Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
title |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
spellingShingle |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? Nielsen, Jens Mortality VDM B/Yamagata B/Yamagata EuroMOMO FluMOMO Influenza Mortality Mortalidade EuroMOMO FluMOMO Influenza Estados de Saúde e de Doença |
title_short |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
title_full |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
title_fullStr |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
title_full_unstemmed |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
title_sort |
European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered? |
author |
Nielsen, Jens |
author_facet |
Nielsen, Jens Vestergaard, Lasse Richter, L. Schmid, D. Bustos, N. Asikainen, T. Trebbien, R. Denissov, G. Innos, K. Virtanen, M.J. Fouillet, A. Lytras, T. Gkolfinopoulou, K. Heiden, M. an der Grabenhenrich, L. Uphoff, H. Paldy, A. Bobvos, J. Domegan, L. O'Donnell, J. Scortichini, M. de Martino, A. Mossong, J. England, K. Melillo, J. van Asten, L. de Lange, M. MA Tønnessen, R. White, R.A. Silva, Susana Pereira Rodrigues, Ana Paula Larrauri, Amparo Mazagatos, Clara Farah, A. Carnahan, A.D. Junker, C. Sinnathamby, M. Pebody, R.G. Andrews, N. Reynolds, A. McMenamin, J. Brown, C.S. Adlhoch, C. Penttinen, P. Mølbak, K. Krause, T.G. |
author_role |
author |
author2 |
Vestergaard, Lasse Richter, L. Schmid, D. Bustos, N. Asikainen, T. Trebbien, R. Denissov, G. Innos, K. Virtanen, M.J. Fouillet, A. Lytras, T. Gkolfinopoulou, K. Heiden, M. an der Grabenhenrich, L. Uphoff, H. Paldy, A. Bobvos, J. Domegan, L. O'Donnell, J. Scortichini, M. de Martino, A. Mossong, J. England, K. Melillo, J. van Asten, L. de Lange, M. MA Tønnessen, R. White, R.A. Silva, Susana Pereira Rodrigues, Ana Paula Larrauri, Amparo Mazagatos, Clara Farah, A. Carnahan, A.D. Junker, C. Sinnathamby, M. Pebody, R.G. Andrews, N. Reynolds, A. McMenamin, J. Brown, C.S. Adlhoch, C. Penttinen, P. Mølbak, K. Krause, T.G. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Nielsen, Jens Vestergaard, Lasse Richter, L. Schmid, D. Bustos, N. Asikainen, T. Trebbien, R. Denissov, G. Innos, K. Virtanen, M.J. Fouillet, A. Lytras, T. Gkolfinopoulou, K. Heiden, M. an der Grabenhenrich, L. Uphoff, H. Paldy, A. Bobvos, J. Domegan, L. O'Donnell, J. Scortichini, M. de Martino, A. Mossong, J. England, K. Melillo, J. van Asten, L. de Lange, M. MA Tønnessen, R. White, R.A. Silva, Susana Pereira Rodrigues, Ana Paula Larrauri, Amparo Mazagatos, Clara Farah, A. Carnahan, A.D. Junker, C. Sinnathamby, M. Pebody, R.G. Andrews, N. Reynolds, A. McMenamin, J. Brown, C.S. Adlhoch, C. Penttinen, P. Mølbak, K. Krause, T.G. |
dc.subject.por.fl_str_mv |
Mortality VDM B/Yamagata B/Yamagata EuroMOMO FluMOMO Influenza Mortality Mortalidade EuroMOMO FluMOMO Influenza Estados de Saúde e de Doença |
topic |
Mortality VDM B/Yamagata B/Yamagata EuroMOMO FluMOMO Influenza Mortality Mortalidade EuroMOMO FluMOMO Influenza Estados de Saúde e de Doença |
description |
Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-18 2019-02-18T00:00:00Z 2020-04-23T16:37:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6499 |
url |
http://hdl.handle.net/10400.18/6499 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clin Microbiol Infect. 2019 Oct;25(10):1266-1276. doi: 10.1016/j.cmi.2019.02.011. Epub 2019 Feb 18 1198-743X 10.1016/j.cmi.2019.02.011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/ on behalf of European Society of Clinical Microbiology and Infectious Diseases |
publisher.none.fl_str_mv |
Elsevier/ on behalf of European Society of Clinical Microbiology and Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132154295222272 |