Omalizumab for Severe Asthma: Beyond Allergic Asthma.

Detalhes bibliográficos
Autor(a) principal: Loureiro, C
Data de Publicação: 2018
Outros Autores: Anmaral, L, Ferreira, A, Lima, R, Pardal, C, Fernandes, I, Semedo, L, Arrobas, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/2055
Resumo: Different subsets of asthma patients may be recognized according to the exposure trigger and the frequency and severity of clinical signs and symptoms. Regarding the exposure trigger, generally asthma can be classified as allergic (or atopic) and nonallergic (or nonatopic). Allergic and nonallergic asthma are distinguished by the presence or absence of clinical allergic reaction and in vitro IgE response to specific aeroallergens. The mechanisms of allergic asthma have been extensively studied with major advances in the last two decades. Nonallergic asthma is characterized by its apparent independence from allergen exposure and sensitization and a higher degree of severity, but little is known regarding the underlying mechanisms. Clinically, allergic and nonallergic asthma are virtually indistinguishable in exacerbations, although exacerbation following allergen exposure is typical of allergic asthma. Although they both show several distinct clinical phenotypes and different biomarkers, there are no ideal biomarkers to stratify asthma phenotypes and guide therapy in clinical practice. Nevertheless, some biomarkers may be helpful to select subsets of atopic patients which might benefit from biologic agents, such as omalizumab. Patients with severe asthma, uncontrolled besides optimal treatment, notwithstanding nonatopic, may also benefit from omalizumab therapy, although currently there are no randomized double-blind placebo controlled clinical trials to support this suggestion. However, omalizumab discontinuation according to each patient's response to therapy and pharmacoeconomical analysis are questions that remain to be answered
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spelling Omalizumab for Severe Asthma: Beyond Allergic Asthma.AsthmaNon-steroidal anti-Inflammatory agentsDifferent subsets of asthma patients may be recognized according to the exposure trigger and the frequency and severity of clinical signs and symptoms. Regarding the exposure trigger, generally asthma can be classified as allergic (or atopic) and nonallergic (or nonatopic). Allergic and nonallergic asthma are distinguished by the presence or absence of clinical allergic reaction and in vitro IgE response to specific aeroallergens. The mechanisms of allergic asthma have been extensively studied with major advances in the last two decades. Nonallergic asthma is characterized by its apparent independence from allergen exposure and sensitization and a higher degree of severity, but little is known regarding the underlying mechanisms. Clinically, allergic and nonallergic asthma are virtually indistinguishable in exacerbations, although exacerbation following allergen exposure is typical of allergic asthma. Although they both show several distinct clinical phenotypes and different biomarkers, there are no ideal biomarkers to stratify asthma phenotypes and guide therapy in clinical practice. Nevertheless, some biomarkers may be helpful to select subsets of atopic patients which might benefit from biologic agents, such as omalizumab. Patients with severe asthma, uncontrolled besides optimal treatment, notwithstanding nonatopic, may also benefit from omalizumab therapy, although currently there are no randomized double-blind placebo controlled clinical trials to support this suggestion. However, omalizumab discontinuation according to each patient's response to therapy and pharmacoeconomical analysis are questions that remain to be answeredHindawi Publishing CorporationRepositório do Hospital Prof. Doutor Fernando FonsecaLoureiro, CAnmaral, LFerreira, ALima, RPardal, CFernandes, ISemedo, LArrobas, A2018-11-19T17:31:11Z2018-01-01T00:00:00Z2018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/2055engBiomed Res Int. 2018 Sep 17;2018:3254094.2314-614110.1155/2018/3254094.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:46Zoai:repositorio.hff.min-saude.pt:10400.10/2055Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:53:03.487715Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Omalizumab for Severe Asthma: Beyond Allergic Asthma.
title Omalizumab for Severe Asthma: Beyond Allergic Asthma.
spellingShingle Omalizumab for Severe Asthma: Beyond Allergic Asthma.
Loureiro, C
Asthma
Non-steroidal anti-Inflammatory agents
title_short Omalizumab for Severe Asthma: Beyond Allergic Asthma.
title_full Omalizumab for Severe Asthma: Beyond Allergic Asthma.
title_fullStr Omalizumab for Severe Asthma: Beyond Allergic Asthma.
title_full_unstemmed Omalizumab for Severe Asthma: Beyond Allergic Asthma.
title_sort Omalizumab for Severe Asthma: Beyond Allergic Asthma.
author Loureiro, C
author_facet Loureiro, C
Anmaral, L
Ferreira, A
Lima, R
Pardal, C
Fernandes, I
Semedo, L
Arrobas, A
author_role author
author2 Anmaral, L
Ferreira, A
Lima, R
Pardal, C
Fernandes, I
Semedo, L
Arrobas, A
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Loureiro, C
Anmaral, L
Ferreira, A
Lima, R
Pardal, C
Fernandes, I
Semedo, L
Arrobas, A
dc.subject.por.fl_str_mv Asthma
Non-steroidal anti-Inflammatory agents
topic Asthma
Non-steroidal anti-Inflammatory agents
description Different subsets of asthma patients may be recognized according to the exposure trigger and the frequency and severity of clinical signs and symptoms. Regarding the exposure trigger, generally asthma can be classified as allergic (or atopic) and nonallergic (or nonatopic). Allergic and nonallergic asthma are distinguished by the presence or absence of clinical allergic reaction and in vitro IgE response to specific aeroallergens. The mechanisms of allergic asthma have been extensively studied with major advances in the last two decades. Nonallergic asthma is characterized by its apparent independence from allergen exposure and sensitization and a higher degree of severity, but little is known regarding the underlying mechanisms. Clinically, allergic and nonallergic asthma are virtually indistinguishable in exacerbations, although exacerbation following allergen exposure is typical of allergic asthma. Although they both show several distinct clinical phenotypes and different biomarkers, there are no ideal biomarkers to stratify asthma phenotypes and guide therapy in clinical practice. Nevertheless, some biomarkers may be helpful to select subsets of atopic patients which might benefit from biologic agents, such as omalizumab. Patients with severe asthma, uncontrolled besides optimal treatment, notwithstanding nonatopic, may also benefit from omalizumab therapy, although currently there are no randomized double-blind placebo controlled clinical trials to support this suggestion. However, omalizumab discontinuation according to each patient's response to therapy and pharmacoeconomical analysis are questions that remain to be answered
publishDate 2018
dc.date.none.fl_str_mv 2018-11-19T17:31:11Z
2018-01-01T00:00:00Z
2018-01-01T00:00:00Z
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.10/2055
url http://hdl.handle.net/10400.10/2055
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biomed Res Int. 2018 Sep 17;2018:3254094.
2314-6141
10.1155/2018/3254094.
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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