Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial

Detalhes bibliográficos
Autor(a) principal: Alves, J. C.
Data de Publicação: 2022
Outros Autores: Santos, A., Jorge, P., Lavrador, C., Carreira, L.Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/24591
Resumo: Research Areas: Science & Technology
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spelling Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trialCaudolateral Curvilinear Osteophytekneeknee OsteoarthritisSynovial-FluidHip-DysplasiaAromatase ExpressionRheumatoid-ArthritisJoint DiseaseLimb FunctionDogsCartilageResearch Areas: Science & TechnologyOsteoarthritis (OA) is a disease with a high negative impact on patient's quality of life and a high financial burden. It is a source of chronic pain and affects all mammals, including humans and dogs. As the dog is a common model for translation research of human OA, and exploring spontaneous dog OA can improve the health and well-being of both humans and dogs. To describe the effect of the intra-articular administration of stanozolol in a naturally occurring canine OA model, forty canine (N = 40) hip joints were randomly assigned to receive stanozolol or saline (control). On treatment day and at 8, 15, 30, 90, and 180 days post-treatment, several evaluations were conducted: weight distribution, joint range of motion, thigh girth, digital thermography, and radiographic signs. Also, synovial fluid C-reactive protein and interleukin-1 levels were evaluated. Results from four Clinical Metrology Instruments was also gathered. Results were compared with Repeated Measures ANOVA, with a Huynh-Feldt correction, paired-samples t-test, or Wilcoxon signed-rank test, with p < 0.05. OA was graded as mild (90%), moderate (5%), and severe (5%), including both sexes. They had a mean age of 6.5 +/- 2.4 years and a bodyweight of 26.7 +/- 5.2 kg. No differences were found between groups at treatment day in all considered evaluations. Weight distribution showed significant improvements with stanozolol from 15 days (p < 0.05) up to 180 days (p < 0.01). Lower values during thermographic evaluation in both views taken and improved joint extension at 90 (p = 0.02) and 180 days (p < 0.01) were observed. Pain and function scores improved up to 180 days. In the control group, radiographic signs progressed, in contrast with stanozolol. The use of stanozolol was safe and produced significant improvements in weight-bearing, pain score, and clinical evaluations in a naturally occurring canine OA model.Nature ResearchRepositório da Universidade de LisboaAlves, J. C.Santos, A.Jorge, P.Lavrador, C.Carreira, L.Miguel2022-06-20T21:38:40Z2022-04-072022-04-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/24591engAlves JC, Santos A, Jorge P, Lavrador C, Carreira LM. 2022. Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model: a randomised trial. Scientifc Reports 12(1):5887. DOI: https://doi.org/10.1038/s41598-022-09934-y2045-232210.1038/s41598-022-09934-yinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:54:11Zoai:www.repository.utl.pt:10400.5/24591Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:08:34.327653Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
title Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
spellingShingle Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
Alves, J. C.
Caudolateral Curvilinear Osteophyteknee
knee Osteoarthritis
Synovial-Fluid
Hip-Dysplasia
Aromatase Expression
Rheumatoid-Arthritis
Joint Disease
Limb Function
Dogs
Cartilage
title_short Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
title_full Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
title_fullStr Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
title_full_unstemmed Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
title_sort Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model : a randomised trial
author Alves, J. C.
author_facet Alves, J. C.
Santos, A.
Jorge, P.
Lavrador, C.
Carreira, L.Miguel
author_role author
author2 Santos, A.
Jorge, P.
Lavrador, C.
Carreira, L.Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Alves, J. C.
Santos, A.
Jorge, P.
Lavrador, C.
Carreira, L.Miguel
dc.subject.por.fl_str_mv Caudolateral Curvilinear Osteophyteknee
knee Osteoarthritis
Synovial-Fluid
Hip-Dysplasia
Aromatase Expression
Rheumatoid-Arthritis
Joint Disease
Limb Function
Dogs
Cartilage
topic Caudolateral Curvilinear Osteophyteknee
knee Osteoarthritis
Synovial-Fluid
Hip-Dysplasia
Aromatase Expression
Rheumatoid-Arthritis
Joint Disease
Limb Function
Dogs
Cartilage
description Research Areas: Science & Technology
publishDate 2022
dc.date.none.fl_str_mv 2022-06-20T21:38:40Z
2022-04-07
2022-04-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/24591
url http://hdl.handle.net/10400.5/24591
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Alves JC, Santos A, Jorge P, Lavrador C, Carreira LM. 2022. Efect of a single intra‑articular administration of stanozolol in a naturally occurring canine osteoarthritis model: a randomised trial. Scientifc Reports 12(1):5887. DOI: https://doi.org/10.1038/s41598-022-09934-y
2045-2322
10.1038/s41598-022-09934-y
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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