Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases

Detalhes bibliográficos
Autor(a) principal: Cascão, Rita
Data de Publicação: 2017
Outros Autores: Fonseca, João E., Moita, Luis F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/773
Resumo: This deposit is composed by the main article, and it hasn't any supplementary materials associated.
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spelling Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseasescelastrolinflammationcancerneurodegenerative diseasestoxicitytreatmentclinical trialsThis deposit is composed by the main article, and it hasn't any supplementary materials associated.The identification of new bioactive compounds derived from medicinal plants with significant therapeutic properties has attracted considerable interest in recent years. Such is the case of the Tripterygium wilfordii (TW), an herb used in Chinese medicine. Clinical trials performed so far using its root extracts have shown impressive therapeutic properties but also revealed substantial gastrointestinal side effects. The most promising bioactive compound obtained from TW is celastrol. During the last decade, an increasing number of studies were published highlighting the medicinal usefulness of celastrol in diverse clinical areas. Here we systematically review the mechanism of action and the therapeutic properties of celastrol in inflammatory diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, osteoarthritis and allergy, as well as in cancer, neurodegenerative disorders and other diseases, such as diabetes, obesity, atherosclerosis, and hearing loss. We will also focus in the toxicological profile and limitations of celastrol formulation, namely, solubility, bioavailability, and dosage issues that still limit its further clinical application and usefulness.Fundação para a Ciência e a Tecnologia grants: (SFRH/BPD/92860/2013, PTDC/BIM-MEC/4665/2014); European Research Council grants: (ERC-2014-CoG 647888-iPROTECTION).Frontiers MediaARCACascão, RitaFonseca, João E.Moita, Luis F.2017-07-12T11:27:21Z2017-06-152017-06-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/773engCascão R, Fonseca JE and Moita LF (2017) Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases. Front. Med. 4:69. doi: 10.3389/fmed.2017.0006910.3389/fmed.2017.00069info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:10Zoai:arca.igc.gulbenkian.pt:10400.7/773Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:59.980562Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
title Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
spellingShingle Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
Cascão, Rita
celastrol
inflammation
cancer
neurodegenerative diseases
toxicity
treatment
clinical trials
title_short Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
title_full Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
title_fullStr Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
title_full_unstemmed Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
title_sort Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
author Cascão, Rita
author_facet Cascão, Rita
Fonseca, João E.
Moita, Luis F.
author_role author
author2 Fonseca, João E.
Moita, Luis F.
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Cascão, Rita
Fonseca, João E.
Moita, Luis F.
dc.subject.por.fl_str_mv celastrol
inflammation
cancer
neurodegenerative diseases
toxicity
treatment
clinical trials
topic celastrol
inflammation
cancer
neurodegenerative diseases
toxicity
treatment
clinical trials
description This deposit is composed by the main article, and it hasn't any supplementary materials associated.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-12T11:27:21Z
2017-06-15
2017-06-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/773
url http://hdl.handle.net/10400.7/773
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cascão R, Fonseca JE and Moita LF (2017) Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases. Front. Med. 4:69. doi: 10.3389/fmed.2017.00069
10.3389/fmed.2017.00069
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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