Design of nutraceutical–mesoporous silica nanoconjugates

Detalhes bibliográficos
Autor(a) principal: Marinheiro, Diogo Filipe Pires
Data de Publicação: 2021
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/30938
Resumo: Resveratrol (RSV) is a nutraceutical naturally present in various foods such as red wine, grape skins, peanuts, among many others. This compound has beneficial properties for human health such as antioxidant, anti-inflammatory and anticancer activities, among others. However, due to is physicochemical characteristics, mainly its low solubility in water that results in low bioavailability, the applicability of this compound is limited. In order to overcome these limitations, nanocarriers based approaches have emerged in the last years. The present work shows the results of the synthesis and characterization of mesoporous silica nanoparticles (MSNs) and evaluates their capacity to encapsulate and in vitro release RSV. With this purpose several synthesis conditions were investigated and two RSV loading methods were tested, by immersion and evaporation. The latter proved to be more effective allowing higher loads. The in vitro release studies suggest an increase in water solubility of the encapsulated RSV, when compared to the free one, and a faster release in acidic medium.
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spelling Design of nutraceutical–mesoporous silica nanoconjugatesResveratrolNutraceuticalsMesoporous silica nanoparticlesManotechnologyBioavailabilityResveratrol (RSV) is a nutraceutical naturally present in various foods such as red wine, grape skins, peanuts, among many others. This compound has beneficial properties for human health such as antioxidant, anti-inflammatory and anticancer activities, among others. However, due to is physicochemical characteristics, mainly its low solubility in water that results in low bioavailability, the applicability of this compound is limited. In order to overcome these limitations, nanocarriers based approaches have emerged in the last years. The present work shows the results of the synthesis and characterization of mesoporous silica nanoparticles (MSNs) and evaluates their capacity to encapsulate and in vitro release RSV. With this purpose several synthesis conditions were investigated and two RSV loading methods were tested, by immersion and evaporation. The latter proved to be more effective allowing higher loads. The in vitro release studies suggest an increase in water solubility of the encapsulated RSV, when compared to the free one, and a faster release in acidic medium.O resveratrol (RSV) é um nutracêutico naturalmente presente em diversos alimentos como o vinho tinto, casca de uva, amendoim entre outros. Possui propriedades benéficas para a saúde humana como atividade antioxidante, anti-inflamatória e anticancerígena, entre outras. Porém, devido às características físico-químicas que apresenta, principalmente baixa solubilidade em água e biodisponibilidade, a sua aplicabilidade é limitada. Nos últimos anos, para contornar estas limitações têm sido desenvolvidas abordagens baseadas em nanotransportadores. Este trabalho apresenta os resultados da síntese e caracterização de nanopartículas de sílica mesoporosas (MSNs) e avalia a sua capacidade de encapsular e libertar, em condições in vitro, o RSV. Com este propósito foram estudadas várias condições de síntese e dois métodos de carregamento foram testados, por imersão e evaporação. O último mostrou ser mais eficaz permitindo carregamentos mais elevados. Os estudos de libertação in vitro sugerem um aumento da solubilidade em água do RSV encapsulado, relativamente à sua forma livre, bem como uma libertação mais rápida em meio ácido.2021-03-19T09:12:33Z2021-02-22T00:00:00Z2021-02-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10773/30938engMarinheiro, Diogo Filipe Piresinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:59:48Zoai:ria.ua.pt:10773/30938Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:02:57.312486Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Design of nutraceutical–mesoporous silica nanoconjugates
title Design of nutraceutical–mesoporous silica nanoconjugates
spellingShingle Design of nutraceutical–mesoporous silica nanoconjugates
Marinheiro, Diogo Filipe Pires
Resveratrol
Nutraceuticals
Mesoporous silica nanoparticles
Manotechnology
Bioavailability
title_short Design of nutraceutical–mesoporous silica nanoconjugates
title_full Design of nutraceutical–mesoporous silica nanoconjugates
title_fullStr Design of nutraceutical–mesoporous silica nanoconjugates
title_full_unstemmed Design of nutraceutical–mesoporous silica nanoconjugates
title_sort Design of nutraceutical–mesoporous silica nanoconjugates
author Marinheiro, Diogo Filipe Pires
author_facet Marinheiro, Diogo Filipe Pires
author_role author
dc.contributor.author.fl_str_mv Marinheiro, Diogo Filipe Pires
dc.subject.por.fl_str_mv Resveratrol
Nutraceuticals
Mesoporous silica nanoparticles
Manotechnology
Bioavailability
topic Resveratrol
Nutraceuticals
Mesoporous silica nanoparticles
Manotechnology
Bioavailability
description Resveratrol (RSV) is a nutraceutical naturally present in various foods such as red wine, grape skins, peanuts, among many others. This compound has beneficial properties for human health such as antioxidant, anti-inflammatory and anticancer activities, among others. However, due to is physicochemical characteristics, mainly its low solubility in water that results in low bioavailability, the applicability of this compound is limited. In order to overcome these limitations, nanocarriers based approaches have emerged in the last years. The present work shows the results of the synthesis and characterization of mesoporous silica nanoparticles (MSNs) and evaluates their capacity to encapsulate and in vitro release RSV. With this purpose several synthesis conditions were investigated and two RSV loading methods were tested, by immersion and evaporation. The latter proved to be more effective allowing higher loads. The in vitro release studies suggest an increase in water solubility of the encapsulated RSV, when compared to the free one, and a faster release in acidic medium.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-19T09:12:33Z
2021-02-22T00:00:00Z
2021-02-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/30938
url http://hdl.handle.net/10773/30938
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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