Elimination of hepatic rodent plasmodium parasites by amino acid supplementation

Detalhes bibliográficos
Autor(a) principal: Meireles, Patricia
Data de Publicação: 2020
Outros Autores: Brás, Daniela, Fontinha, Diana, Chora, Ângelo Ferreira, Serre, Karine, Mendes, António M., Prudêncio, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47274
Resumo: © 2020 The Authors.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
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spelling Elimination of hepatic rodent plasmodium parasites by amino acid supplementationDietParasitologyPhysiology© 2020 The Authors.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)Plasmodium parasites, causative agents of malaria, scavenge host nutrients to sustain their intracellular replication. Modulation of the host's nutritional status can potentially help control infection by limiting the parasite's access to nutrients, or by boosting the immune system. Here, we show that dietary supplementation of mice employing a combination of arginine (R) with two additional amino acids, lysine (K) and valine (V), termed RKV, significantly decreases Plasmodium liver infection. RKV supplementation results in the elimination of parasites at a late stage of their development in the liver. Our data employing genetic knockout mouse models and in vivo depletion of specific cell populations suggest that RKV supplementation boosts the host's overall innate immune response, and that parasite elimination is dependent on MyD88 signaling in immune cells. The immunostimulatory effect of RKV supplementation opens a potential role for dietary supplementation as an adjuvant for prophylaxis or immunization strategies against Plasmodium infection.This work was supported by Fundação para a Ciência e a Tecnologia , Portugal, through Grant PTDC/SAU-INF/29550/2017 to MP.ElsevierRepositório da Universidade de LisboaMeireles, PatriciaBrás, DanielaFontinha, DianaChora, Ângelo FerreiraSerre, KarineMendes, António M.Prudêncio, Miguel2021-04-07T12:31:35Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47274engiScience. 2020 Nov 6;23(12):10178110.1016/j.isci.2020.1017812589-0042info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:05:36Zoai:repositorio.ul.pt:10451/47274Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:05:36Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
title Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
spellingShingle Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
Meireles, Patricia
Diet
Parasitology
Physiology
title_short Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
title_full Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
title_fullStr Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
title_full_unstemmed Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
title_sort Elimination of hepatic rodent plasmodium parasites by amino acid supplementation
author Meireles, Patricia
author_facet Meireles, Patricia
Brás, Daniela
Fontinha, Diana
Chora, Ângelo Ferreira
Serre, Karine
Mendes, António M.
Prudêncio, Miguel
author_role author
author2 Brás, Daniela
Fontinha, Diana
Chora, Ângelo Ferreira
Serre, Karine
Mendes, António M.
Prudêncio, Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Meireles, Patricia
Brás, Daniela
Fontinha, Diana
Chora, Ângelo Ferreira
Serre, Karine
Mendes, António M.
Prudêncio, Miguel
dc.subject.por.fl_str_mv Diet
Parasitology
Physiology
topic Diet
Parasitology
Physiology
description © 2020 The Authors.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-07T12:31:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47274
url http://hdl.handle.net/10451/47274
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv iScience. 2020 Nov 6;23(12):101781
10.1016/j.isci.2020.101781
2589-0042
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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