Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.34631/sporl.2048 |
Resumo: | Introduction: A promising technique to treat persistent olfactory impairment has recently been explored: platelet rich plasma (PRP) injection into the olfactory mucosa. Objectives: This study aimed to determine efficacy, safety, and feasibility of a new PRP injection protocol in treating persistent COVID-19 induced olfactory dysfunction (pCIOD). Material and Methods: Patients with pCIOD lasting for ≥ 12 months were enrolled. All patients had previously performed olfactory training and adjuvant therapy without achieving substantial improvement. Olfactory perception threshold (OPT) and visual analog scale (VAS) were measured at baseline, one month and three months after injection. Results: Twenty patients were enrolled. There was a significant change in OPT after injection (mean baseline OPT: 4.36 ± 1.6 versus 1-month after injection: 6.9 ± 2.6, p = 0.012 versus 3-months after injection: 7.2 ± 2.8, p =0.009). No severe complications were reported. Conclusions: Single-site PRP injection into the olfactory mucosa is a novel, safe and effective approach that may enhance olfactory recovery in pCIOD patients. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective studyPlasma rico em plaquetas na disfunção olfativa persistente após COVID-19: um estudo prospetivodisfunção olfativaanosmiahiposmiaplasma rico em plaquetaslocal únicoinjeçãoCOVID-19COVID-19olfactory dysfunctionanosmiahyposmiaplatelet rich plasmasingle-siteinjectionIntroduction: A promising technique to treat persistent olfactory impairment has recently been explored: platelet rich plasma (PRP) injection into the olfactory mucosa. Objectives: This study aimed to determine efficacy, safety, and feasibility of a new PRP injection protocol in treating persistent COVID-19 induced olfactory dysfunction (pCIOD). Material and Methods: Patients with pCIOD lasting for ≥ 12 months were enrolled. All patients had previously performed olfactory training and adjuvant therapy without achieving substantial improvement. Olfactory perception threshold (OPT) and visual analog scale (VAS) were measured at baseline, one month and three months after injection. Results: Twenty patients were enrolled. There was a significant change in OPT after injection (mean baseline OPT: 4.36 ± 1.6 versus 1-month after injection: 6.9 ± 2.6, p = 0.012 versus 3-months after injection: 7.2 ± 2.8, p =0.009). No severe complications were reported. Conclusions: Single-site PRP injection into the olfactory mucosa is a novel, safe and effective approach that may enhance olfactory recovery in pCIOD patients.Introdução: A injeção de plasma rico em plaquetas (PRP) na mucosa olfativa é uma técnica inovadora e promissora no tratamento da disfunção olfativa persistente. Objetivos: O objetivo deste estudo foi determinar a eficácia, segurança e viabilidade de um novo protocolo de injeção de PRP no tratamento da disfunção olfativa persistente induzida pela COVID-19 (DOPIC). Material e métodos: Foram incluídos doentes com DOPIC com duração igual ou superior a 12 meses. Todos tinham previamente realizado treino olfativo e terapêutica adjuvante sem terem obtido melhoria significativa. Os valores do limiar de perceção olfativa (LPO) e da escala visual analógica (EVA) foram medidos antes, 1 mês e 3 meses após a injeção. Resultados: Foram incluídos 20 doentes. Constatou-se uma alteração significativa nos valores de LPO após a injeção (valores médios de LPO de base: 4,36 ± 1,6 versus 1 mês pós-injeção: 6,9 ± 2,6, p = 0,012 versus 3 meses pós-injeção: 7.2 ± 2.8, p = 0.009). Não foram registadas complicações graves. Conclusões: A injeção de PRP em local único na mucosa olfativa é uma nova abordagem, segura e eficaz, que pode melhorar a recuperação olfativa nos doentes com DOPIC.Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2023-12-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.34631/sporl.2048https://doi.org/10.34631/sporl.2048Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 61 No. 4 (2023): December; 345-354Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 61 Núm. 4 (2023): Dezembro; 345-354Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 61 N.º 4 (2023): Dezembro; 345-3542184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporenghttps://journalsporl.com/index.php/sporl/article/view/2048https://journalsporl.com/index.php/sporl/article/view/2048/78https://journalsporl.com/index.php/sporl/article/view/2048/77Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessAlves de Sousa, Franciscode Sousa Machado, AndréCosta, Joana RaquelTavares Correia, JoãoCastro, AfonsoNóbrega Pinto, AnaSilva, AnaSantos, MarilineMeireles, Luís2024-01-25T13:38:23Zoai:journalsporl.com:article/2048Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:56:37.086650Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study Plasma rico em plaquetas na disfunção olfativa persistente após COVID-19: um estudo prospetivo |
title |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
spellingShingle |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study Alves de Sousa, Francisco disfunção olfativa anosmia hiposmia plasma rico em plaquetas local único injeção COVID-19 COVID-19 olfactory dysfunction anosmia hyposmia platelet rich plasma single-site injection |
title_short |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
title_full |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
title_fullStr |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
title_full_unstemmed |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
title_sort |
Use of platelet rich plasma in persistent olfactory dysfunction after COVID-19: a prospective study |
author |
Alves de Sousa, Francisco |
author_facet |
Alves de Sousa, Francisco de Sousa Machado, André Costa, Joana Raquel Tavares Correia, João Castro, Afonso Nóbrega Pinto, Ana Silva, Ana Santos, Mariline Meireles, Luís |
author_role |
author |
author2 |
de Sousa Machado, André Costa, Joana Raquel Tavares Correia, João Castro, Afonso Nóbrega Pinto, Ana Silva, Ana Santos, Mariline Meireles, Luís |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Alves de Sousa, Francisco de Sousa Machado, André Costa, Joana Raquel Tavares Correia, João Castro, Afonso Nóbrega Pinto, Ana Silva, Ana Santos, Mariline Meireles, Luís |
dc.subject.por.fl_str_mv |
disfunção olfativa anosmia hiposmia plasma rico em plaquetas local único injeção COVID-19 COVID-19 olfactory dysfunction anosmia hyposmia platelet rich plasma single-site injection |
topic |
disfunção olfativa anosmia hiposmia plasma rico em plaquetas local único injeção COVID-19 COVID-19 olfactory dysfunction anosmia hyposmia platelet rich plasma single-site injection |
description |
Introduction: A promising technique to treat persistent olfactory impairment has recently been explored: platelet rich plasma (PRP) injection into the olfactory mucosa. Objectives: This study aimed to determine efficacy, safety, and feasibility of a new PRP injection protocol in treating persistent COVID-19 induced olfactory dysfunction (pCIOD). Material and Methods: Patients with pCIOD lasting for ≥ 12 months were enrolled. All patients had previously performed olfactory training and adjuvant therapy without achieving substantial improvement. Olfactory perception threshold (OPT) and visual analog scale (VAS) were measured at baseline, one month and three months after injection. Results: Twenty patients were enrolled. There was a significant change in OPT after injection (mean baseline OPT: 4.36 ± 1.6 versus 1-month after injection: 6.9 ± 2.6, p = 0.012 versus 3-months after injection: 7.2 ± 2.8, p =0.009). No severe complications were reported. Conclusions: Single-site PRP injection into the olfactory mucosa is a novel, safe and effective approach that may enhance olfactory recovery in pCIOD patients. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.34631/sporl.2048 https://doi.org/10.34631/sporl.2048 |
url |
https://doi.org/10.34631/sporl.2048 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://journalsporl.com/index.php/sporl/article/view/2048 https://journalsporl.com/index.php/sporl/article/view/2048/78 https://journalsporl.com/index.php/sporl/article/view/2048/77 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço |
dc.source.none.fl_str_mv |
Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 61 No. 4 (2023): December; 345-354 Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 61 Núm. 4 (2023): Dezembro; 345-354 Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 61 N.º 4 (2023): Dezembro; 345-354 2184-6499 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799136450532343808 |