Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/56240 |
Resumo: | © 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
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Transmural remission improves clinical outcomes up to 5 years in Crohn's diseaseCrohn's diseaseMRI enterographyEndoscopyInflammatory bowel diseaseTransmural remission© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.Introduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five-year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between patients with TR, IER, IRR, and no remission (NR). Results: 20.8% of CD patients presented TR, 23.3% IER, 13.6% IRR and 42.3% NR. TR was associated with lower risk of hospitalization (odds-ratio [OR] 0.244 [0.111-0.538], p < 0.001), surgery (OR 0.132 [0.030-0.585], p = 0.008), steroid use (OR 0.283 [0.159-0.505], p < 0.001), and treatment escalation (OR 0.088 [0.044-0.176], p < 0.001) compared to no NR. IRR resulted in lower risk of hospitalization (OR 0.333 [0.143-0.777], p = 0.011) and treatment escalation (OR 0.260 [0.125-0.540], p < 0.001), while IER reduced the risk of steroid use (OR 0.442 [0.262-0.745], p = 0.002) and treatment escalation (OR 0.490 [0.259-0.925], p = 0.028) compared to NR. Conclusions: TR improved clinical outcomes over 5 years of follow-up in CD patients. Distinct but significant benefits were seen with IER and IRR. This suggests that both endoscopic and radiologic remission should be part of the treatment targets of CD.WileyRepositório da Universidade de LisboaFernandes, SamuelSerrazina, JulianaBotto, Inês AyalaLeal, TiagoGuimarães, AndreiaGarcia, Joana LemosRosa, IsadoraPrata, RitaCarvalho, DianaNeves, JoãoCampelo, PedroVentura, SofiaSilva, AndreaCoelho, MarianaSequeira, CristianaOliveira, Ana PaulaPortela, FranciscoMinistro, PaulaTavares de Sousa, HelenaRamos, JaimeClaro, IsabelGonçalves, RaquelCorreia, Luís AraújoMarinho, RuiCortez-Pinto, HelenaMagro, Fernando2023-02-09T12:39:41Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56240engUnited European Gastroenterol J. 2023 Feb;11(1):51-592050-640610.1002/ueg2.123562050-6414info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:03:42Zoai:repositorio.ul.pt:10451/56240Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:47.708144Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| title |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| spellingShingle |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease Fernandes, Samuel Crohn's disease MRI enterography Endoscopy Inflammatory bowel disease Transmural remission |
| title_short |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| title_full |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| title_fullStr |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| title_full_unstemmed |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| title_sort |
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease |
| author |
Fernandes, Samuel |
| author_facet |
Fernandes, Samuel Serrazina, Juliana Botto, Inês Ayala Leal, Tiago Guimarães, Andreia Garcia, Joana Lemos Rosa, Isadora Prata, Rita Carvalho, Diana Neves, João Campelo, Pedro Ventura, Sofia Silva, Andrea Coelho, Mariana Sequeira, Cristiana Oliveira, Ana Paula Portela, Francisco Ministro, Paula Tavares de Sousa, Helena Ramos, Jaime Claro, Isabel Gonçalves, Raquel Correia, Luís Araújo Marinho, Rui Cortez-Pinto, Helena Magro, Fernando |
| author_role |
author |
| author2 |
Serrazina, Juliana Botto, Inês Ayala Leal, Tiago Guimarães, Andreia Garcia, Joana Lemos Rosa, Isadora Prata, Rita Carvalho, Diana Neves, João Campelo, Pedro Ventura, Sofia Silva, Andrea Coelho, Mariana Sequeira, Cristiana Oliveira, Ana Paula Portela, Francisco Ministro, Paula Tavares de Sousa, Helena Ramos, Jaime Claro, Isabel Gonçalves, Raquel Correia, Luís Araújo Marinho, Rui Cortez-Pinto, Helena Magro, Fernando |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Fernandes, Samuel Serrazina, Juliana Botto, Inês Ayala Leal, Tiago Guimarães, Andreia Garcia, Joana Lemos Rosa, Isadora Prata, Rita Carvalho, Diana Neves, João Campelo, Pedro Ventura, Sofia Silva, Andrea Coelho, Mariana Sequeira, Cristiana Oliveira, Ana Paula Portela, Francisco Ministro, Paula Tavares de Sousa, Helena Ramos, Jaime Claro, Isabel Gonçalves, Raquel Correia, Luís Araújo Marinho, Rui Cortez-Pinto, Helena Magro, Fernando |
| dc.subject.por.fl_str_mv |
Crohn's disease MRI enterography Endoscopy Inflammatory bowel disease Transmural remission |
| topic |
Crohn's disease MRI enterography Endoscopy Inflammatory bowel disease Transmural remission |
| description |
© 2022 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z 2023-02-09T12:39:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/56240 |
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http://hdl.handle.net/10451/56240 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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United European Gastroenterol J. 2023 Feb;11(1):51-59 2050-6406 10.1002/ueg2.12356 2050-6414 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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