The renin–angiotensin system : a possible new target for depression
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/44853 |
| Resumo: | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
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The renin–angiotensin system : a possible new target for depressionDepressionPsychiatryInflammationRenin–angiotensin systemAngiotensinATR1ATR2MasAngiotensin receptor blockersAngiotensin-converting enzyme inhibitorsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin–angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin–angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment.BSF is supported by a postdoctoral fellowship from Deakin University,Australia. CAK is supported by a postdoctoral scholarship from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; Brazil). AFC is supported by a research fellowship award from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; Brazil). MB is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (grant number 1059660). The Department of Psychiatry and Behavioral Sciences of McGovern Medical School (USA) funds the Translational Psychiatry Program. The University of Texas Health Science Center at Houston (UTHealth). Laboratory of Neurosciences (Brazil) is a National Institute for Molecular Medicine centre, and a member of the Center of Excellence in Applied Neurosciences of Santa Catarina. Its research is supported by grants from CNPq (JQ), Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (JQ); Instituto Cérebro e Mente (JQ) and Universidade do Extremo Sul Catarinense (JQ). JQis a 1A CNPq Research Fellow. MB is supported by an NHMRC Senior Principal Research Fellowship (GNT1059660).Springer NatureRepositório da Universidade de LisboaVian, JoãoPereira, CíriaChavarria, VictorKöhler, CristianoStubbs, BrendonQuevedo, JoãoKim, Sung-WanCarvalho, André F.Berk, MichaelFernandes, Brisa S.2020-11-12T11:36:22Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/44853engBMC Med. 2017 Aug 1;15(1):144.10.1186/s12916-017-0916-31741-7015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:00:31Zoai:repositorio.ul.pt:10451/44853Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:00:31Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The renin–angiotensin system : a possible new target for depression |
| title |
The renin–angiotensin system : a possible new target for depression |
| spellingShingle |
The renin–angiotensin system : a possible new target for depression Vian, João Depression Psychiatry Inflammation Renin–angiotensin system Angiotensin ATR1 ATR2 Mas Angiotensin receptor blockers Angiotensin-converting enzyme inhibitors |
| title_short |
The renin–angiotensin system : a possible new target for depression |
| title_full |
The renin–angiotensin system : a possible new target for depression |
| title_fullStr |
The renin–angiotensin system : a possible new target for depression |
| title_full_unstemmed |
The renin–angiotensin system : a possible new target for depression |
| title_sort |
The renin–angiotensin system : a possible new target for depression |
| author |
Vian, João |
| author_facet |
Vian, João Pereira, Círia Chavarria, Victor Köhler, Cristiano Stubbs, Brendon Quevedo, João Kim, Sung-Wan Carvalho, André F. Berk, Michael Fernandes, Brisa S. |
| author_role |
author |
| author2 |
Pereira, Círia Chavarria, Victor Köhler, Cristiano Stubbs, Brendon Quevedo, João Kim, Sung-Wan Carvalho, André F. Berk, Michael Fernandes, Brisa S. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Vian, João Pereira, Círia Chavarria, Victor Köhler, Cristiano Stubbs, Brendon Quevedo, João Kim, Sung-Wan Carvalho, André F. Berk, Michael Fernandes, Brisa S. |
| dc.subject.por.fl_str_mv |
Depression Psychiatry Inflammation Renin–angiotensin system Angiotensin ATR1 ATR2 Mas Angiotensin receptor blockers Angiotensin-converting enzyme inhibitors |
| topic |
Depression Psychiatry Inflammation Renin–angiotensin system Angiotensin ATR1 ATR2 Mas Angiotensin receptor blockers Angiotensin-converting enzyme inhibitors |
| description |
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z 2020-11-12T11:36:22Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/44853 |
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http://hdl.handle.net/10451/44853 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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BMC Med. 2017 Aug 1;15(1):144. 10.1186/s12916-017-0916-3 1741-7015 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Springer Nature |
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Springer Nature |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817549108061143040 |
