Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting

Detalhes bibliográficos
Autor(a) principal: Bouça-Machado, Raquel
Data de Publicação: 2017
Outros Autores: Rosário, Madalena, Alarcão, Joana, Correia Guedes, Leonor, Abreu, Daisy, Ferreira, Joaquim J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/40529
Resumo: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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spelling Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reportingPalliative careMethodological qualityRisk of biasClinical trials© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Over the past decades there has been a significant increase in the number of published clinical trials in palliative care. However, empirical evidence suggests that there are methodological problems in the design and conduct of studies, which raises questions about the validity and generalisability of the results and of the strength of the available evidence. We sought to evaluate the methodological characteristics and assess the quality of reporting of clinical trials in palliative care. Methods: We performed a systematic review of published clinical trials assessing therapeutic interventions in palliative care. Trials were identified using MEDLINE (from its inception to February 2015). We assessed methodological characteristics and describe the quality of reporting using the Cochrane Risk of Bias tool. Results: We retrieved 107 studies. The most common medical field studied was oncology, and 43.9% of trials evaluated pharmacological interventions. Symptom control and physical dimensions (e.g. intervention on pain, breathlessness, nausea) were the palliative care-specific issues most studied. We found under-reporting of key information in particular on random sequence generation, allocation concealment, and blinding. Conclusions: While the number of clinical trials in palliative care has increased over time, methodological quality remains suboptimal. This compromises the quality of studies. Therefore, a greater effort is needed to enable the appropriate performance of future studies and increase the robustness of evidence-based medicine in this important field.BMCRepositório da Universidade de LisboaBouça-Machado, RaquelRosário, MadalenaAlarcão, JoanaCorreia Guedes, LeonorAbreu, DaisyFerreira, Joaquim J.2019-12-12T15:21:33Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/40529engBMC Palliat Care 16, 10 (2017)10.1186/s12904-016-0181-91472-684Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T17:54:49Zoai:repositorio.ul.pt:10451/40529Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T17:54:49Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
title Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
spellingShingle Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
Bouça-Machado, Raquel
Palliative care
Methodological quality
Risk of bias
Clinical trials
title_short Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
title_full Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
title_fullStr Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
title_full_unstemmed Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
title_sort Clinical trials in palliative care : a systematic review of their methodological characteristics and of the quality of their reporting
author Bouça-Machado, Raquel
author_facet Bouça-Machado, Raquel
Rosário, Madalena
Alarcão, Joana
Correia Guedes, Leonor
Abreu, Daisy
Ferreira, Joaquim J.
author_role author
author2 Rosário, Madalena
Alarcão, Joana
Correia Guedes, Leonor
Abreu, Daisy
Ferreira, Joaquim J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bouça-Machado, Raquel
Rosário, Madalena
Alarcão, Joana
Correia Guedes, Leonor
Abreu, Daisy
Ferreira, Joaquim J.
dc.subject.por.fl_str_mv Palliative care
Methodological quality
Risk of bias
Clinical trials
topic Palliative care
Methodological quality
Risk of bias
Clinical trials
description © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2019-12-12T15:21:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/40529
url http://hdl.handle.net/10451/40529
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BMC Palliat Care 16, 10 (2017)
10.1186/s12904-016-0181-9
1472-684X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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