Reappraising striatal D1- and D2-neurons in reward and aversion
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/47044 |
Resumo: | The striatum has been involved in complex behaviors such as motor control, learning, decision-making, reward and aversion. The striatum is mainly composed of medium spiny neurons (MSNs), typically divided into those expressing dopamine receptor D1, forming the so-called direct pathway, and those expressing D2 receptor (indirect pathway). For decades it has been proposed that these two populations exhibit opposing control over motor output, and recently, the same dichotomy has been proposed for valenced behaviors. Whereas D1-MSNs mediate reinforcement and reward, D2-MSNs have been associated with punishment and aversion. In this review we will discuss pharmacological, genetic and optogenetic studies that indicate that there is still controversy to what concerns the role of striatal D1- and D2-MSNs in this type of behaviors, highlighting the need to reconsider the early view that they mediate solely opposing aspects of valenced behaviour. |
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Reappraising striatal D1- and D2-neurons in reward and aversionDopamineRewardReinforcementAversionNucleus accumbensDorsal striatumD1 dopamine receptorD2 dopamine receptorMesolimbicNigrostriatalMedium spiny neuronsScience & TechnologyThe striatum has been involved in complex behaviors such as motor control, learning, decision-making, reward and aversion. The striatum is mainly composed of medium spiny neurons (MSNs), typically divided into those expressing dopamine receptor D1, forming the so-called direct pathway, and those expressing D2 receptor (indirect pathway). For decades it has been proposed that these two populations exhibit opposing control over motor output, and recently, the same dichotomy has been proposed for valenced behaviors. Whereas D1-MSNs mediate reinforcement and reward, D2-MSNs have been associated with punishment and aversion. In this review we will discuss pharmacological, genetic and optogenetic studies that indicate that there is still controversy to what concerns the role of striatal D1- and D2-MSNs in this type of behaviors, highlighting the need to reconsider the early view that they mediate solely opposing aspects of valenced behaviour.CS-C and BC are recipients of Fundação para a Ciência e Tecnologia (FCT) fellowships (SFRH/BD/51992/2012; SFRH/BD/98675/2013). AJR is a FCT investigator (IF/00883/2013). Authors are funded by the Portuguese North Regional Operational Program (ON.2-O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER); and by the Projeto Estratégico − LA 26-2013–2014 (PEst-C/SAU/LA0026/2013).info:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoCunha, Carina Isabel SoaresCoimbra, Bárbara Guimarães SalazarSousa, NunoRodrigues, Ana João20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/47044eng0149-76341873-752810.1016/j.neubiorev.2016.05.02127235078https://www.journals.elsevier.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:44:29Zoai:repositorium.sdum.uminho.pt:1822/47044Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:42:10.453472Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Reappraising striatal D1- and D2-neurons in reward and aversion |
title |
Reappraising striatal D1- and D2-neurons in reward and aversion |
spellingShingle |
Reappraising striatal D1- and D2-neurons in reward and aversion Cunha, Carina Isabel Soares Dopamine Reward Reinforcement Aversion Nucleus accumbens Dorsal striatum D1 dopamine receptor D2 dopamine receptor Mesolimbic Nigrostriatal Medium spiny neurons Science & Technology |
title_short |
Reappraising striatal D1- and D2-neurons in reward and aversion |
title_full |
Reappraising striatal D1- and D2-neurons in reward and aversion |
title_fullStr |
Reappraising striatal D1- and D2-neurons in reward and aversion |
title_full_unstemmed |
Reappraising striatal D1- and D2-neurons in reward and aversion |
title_sort |
Reappraising striatal D1- and D2-neurons in reward and aversion |
author |
Cunha, Carina Isabel Soares |
author_facet |
Cunha, Carina Isabel Soares Coimbra, Bárbara Guimarães Salazar Sousa, Nuno Rodrigues, Ana João |
author_role |
author |
author2 |
Coimbra, Bárbara Guimarães Salazar Sousa, Nuno Rodrigues, Ana João |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cunha, Carina Isabel Soares Coimbra, Bárbara Guimarães Salazar Sousa, Nuno Rodrigues, Ana João |
dc.subject.por.fl_str_mv |
Dopamine Reward Reinforcement Aversion Nucleus accumbens Dorsal striatum D1 dopamine receptor D2 dopamine receptor Mesolimbic Nigrostriatal Medium spiny neurons Science & Technology |
topic |
Dopamine Reward Reinforcement Aversion Nucleus accumbens Dorsal striatum D1 dopamine receptor D2 dopamine receptor Mesolimbic Nigrostriatal Medium spiny neurons Science & Technology |
description |
The striatum has been involved in complex behaviors such as motor control, learning, decision-making, reward and aversion. The striatum is mainly composed of medium spiny neurons (MSNs), typically divided into those expressing dopamine receptor D1, forming the so-called direct pathway, and those expressing D2 receptor (indirect pathway). For decades it has been proposed that these two populations exhibit opposing control over motor output, and recently, the same dichotomy has been proposed for valenced behaviors. Whereas D1-MSNs mediate reinforcement and reward, D2-MSNs have been associated with punishment and aversion. In this review we will discuss pharmacological, genetic and optogenetic studies that indicate that there is still controversy to what concerns the role of striatal D1- and D2-MSNs in this type of behaviors, highlighting the need to reconsider the early view that they mediate solely opposing aspects of valenced behaviour. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/47044 |
url |
http://hdl.handle.net/1822/47044 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0149-7634 1873-7528 10.1016/j.neubiorev.2016.05.021 27235078 https://www.journals.elsevier.com |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132973825523712 |