Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/141367 |
Resumo: | Publisher Copyright: © 2022 The Authors |
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Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levelsatherosclerosiscoronary computed tomography angiographyhemoglobinCardiology and Cardiovascular MedicinePublisher Copyright: © 2022 The AuthorsBackground: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels. (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging [PARADIGM]; NCT02803411)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNWon, Ki BumLee, Byoung KwonHeo, RanPark, Hyung BokLin, Fay Y.Hadamitzky, MartinKim, Yong JinSung, Ji MinConte, EdoardoAndreini, DanielePontone, GianlucaBudoff, Matthew J.Gottlieb, IlanChun, Eun JuCademartiri, FilippoMaffei, EricaPinto Marques, Hugode Araújo Gonçalves, PedroLeipsic, Jonathon A.Lee, Sang EunShin, SanghoonChoi, Jung HyunVirmani, RenuSamady, HabibChinnaiyan, KavithaBerman, Daniel S.Narula, JagatBax, Jeroen J.Min, James K.Chang, Hyuk Jae2022-07-04T22:24:05Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/141367eng2772-3747PURE: 44981062https://doi.org/10.1016/j.jacasi.2021.10.010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-21T01:36:26Zoai:run.unl.pt:10362/141367Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-21T01:36:26Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| title |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| spellingShingle |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels Won, Ki Bum atherosclerosis coronary computed tomography angiography hemoglobin Cardiology and Cardiovascular Medicine |
| title_short |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| title_full |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| title_fullStr |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| title_full_unstemmed |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| title_sort |
Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels |
| author |
Won, Ki Bum |
| author_facet |
Won, Ki Bum Lee, Byoung Kwon Heo, Ran Park, Hyung Bok Lin, Fay Y. Hadamitzky, Martin Kim, Yong Jin Sung, Ji Min Conte, Edoardo Andreini, Daniele Pontone, Gianluca Budoff, Matthew J. Gottlieb, Ilan Chun, Eun Ju Cademartiri, Filippo Maffei, Erica Pinto Marques, Hugo de Araújo Gonçalves, Pedro Leipsic, Jonathon A. Lee, Sang Eun Shin, Sanghoon Choi, Jung Hyun Virmani, Renu Samady, Habib Chinnaiyan, Kavitha Berman, Daniel S. Narula, Jagat Bax, Jeroen J. Min, James K. Chang, Hyuk Jae |
| author_role |
author |
| author2 |
Lee, Byoung Kwon Heo, Ran Park, Hyung Bok Lin, Fay Y. Hadamitzky, Martin Kim, Yong Jin Sung, Ji Min Conte, Edoardo Andreini, Daniele Pontone, Gianluca Budoff, Matthew J. Gottlieb, Ilan Chun, Eun Ju Cademartiri, Filippo Maffei, Erica Pinto Marques, Hugo de Araújo Gonçalves, Pedro Leipsic, Jonathon A. Lee, Sang Eun Shin, Sanghoon Choi, Jung Hyun Virmani, Renu Samady, Habib Chinnaiyan, Kavitha Berman, Daniel S. Narula, Jagat Bax, Jeroen J. Min, James K. Chang, Hyuk Jae |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Won, Ki Bum Lee, Byoung Kwon Heo, Ran Park, Hyung Bok Lin, Fay Y. Hadamitzky, Martin Kim, Yong Jin Sung, Ji Min Conte, Edoardo Andreini, Daniele Pontone, Gianluca Budoff, Matthew J. Gottlieb, Ilan Chun, Eun Ju Cademartiri, Filippo Maffei, Erica Pinto Marques, Hugo de Araújo Gonçalves, Pedro Leipsic, Jonathon A. Lee, Sang Eun Shin, Sanghoon Choi, Jung Hyun Virmani, Renu Samady, Habib Chinnaiyan, Kavitha Berman, Daniel S. Narula, Jagat Bax, Jeroen J. Min, James K. Chang, Hyuk Jae |
| dc.subject.por.fl_str_mv |
atherosclerosis coronary computed tomography angiography hemoglobin Cardiology and Cardiovascular Medicine |
| topic |
atherosclerosis coronary computed tomography angiography hemoglobin Cardiology and Cardiovascular Medicine |
| description |
Publisher Copyright: © 2022 The Authors |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-07-04T22:24:05Z 2022-06 2022-06-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/141367 |
| url |
http://hdl.handle.net/10362/141367 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2772-3747 PURE: 44981062 https://doi.org/10.1016/j.jacasi.2021.10.010 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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9 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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1817545873569087488 |