Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/153235 |
Resumo: | Funding: Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/46929/ 2008 and PTDC/SAUESA/102367/2008). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehydeGeneticsToxicologyGenetics(clinical)Health, Toxicology and MutagenesisSDG 3 - Good Health and Well-beingFunding: Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/46929/ 2008 and PTDC/SAUESA/102367/2008).Formaldehyde (FA) is a commonly used chemical in anatomy and pathology laboratories as a tissue preservative and fixative. Because of its sensitising properties, irritating effects and cancer implication, FA accounts probably for the most important chemical-exposure hazard concerning this professional group. Evidence for genotoxic effects and carcinogenic properties in humans is insufficient and conflicting, particularly in regard to the ability of inhaled FA to induce toxicity on other cells besides first contact tissues, such as buccal and nasal cells. To evaluate the effects of exposure to FA in human peripheral blood lymphocytes, a group of 84 anatomy pathology laboratory workers exposed occupationally to FA and 87 control subjects were tested for chromosomal aberrations (CAs) and DNA damage (comet assay). The level of exposure to FA in the workplace air was evaluated. The association between genotoxicity biomarkers and polymorphic genes of xenobiotic-metabolising and DNA repair enzymes were also assessed. The estimated mean level of FA exposure was 0.38±0.03 ppm. All cytogenetic endpoints assessed by CAs test and comet assay % tail DNA (%TDNA) were significantly higher in FA-exposed workers compared with controls. Regarding the effect of susceptibility biomarkers, results suggest that polymorphisms in CYP2E1 and GSTP1 metabolic genes, as well as, XRCC1 and PARP1 polymorphic genes involved in DNA repair pathways are associated with higher genetic damage in FA-exposed subjects. Data obtained in this study show a potential health risk situation of anatomy pathology laboratory workers exposed to FA (0.38 ppm). Implementation of security and hygiene measures may be crucial to decrease risk. The obtained information may also provide new important data to be used by health care programs and by governmental agencies responsible for occupational health and safety.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNCosta, SolangeCarvalho, SandraCosta, CarlaCoelho, PatríciaSilva, SusanaSantos, Luís S.Gaspar, Jorge F.Porto, BeatrizLaffon, BlancaTeixeira, João P.2023-05-26T22:22:13Z2015-07-012015-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/153235eng0267-8357PURE: 61679345https://doi.org/10.1093/mutage/gev002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:35:51Zoai:run.unl.pt:10362/153235Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:13.979021Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| title |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| spellingShingle |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde Costa, Solange Genetics Toxicology Genetics(clinical) Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being |
| title_short |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| title_full |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| title_fullStr |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| title_full_unstemmed |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| title_sort |
Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde |
| author |
Costa, Solange |
| author_facet |
Costa, Solange Carvalho, Sandra Costa, Carla Coelho, Patrícia Silva, Susana Santos, Luís S. Gaspar, Jorge F. Porto, Beatriz Laffon, Blanca Teixeira, João P. |
| author_role |
author |
| author2 |
Carvalho, Sandra Costa, Carla Coelho, Patrícia Silva, Susana Santos, Luís S. Gaspar, Jorge F. Porto, Beatriz Laffon, Blanca Teixeira, João P. |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centre for Toxicogenomics and Human Health (ToxOmics) RUN |
| dc.contributor.author.fl_str_mv |
Costa, Solange Carvalho, Sandra Costa, Carla Coelho, Patrícia Silva, Susana Santos, Luís S. Gaspar, Jorge F. Porto, Beatriz Laffon, Blanca Teixeira, João P. |
| dc.subject.por.fl_str_mv |
Genetics Toxicology Genetics(clinical) Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being |
| topic |
Genetics Toxicology Genetics(clinical) Health, Toxicology and Mutagenesis SDG 3 - Good Health and Well-being |
| description |
Funding: Fundação para a Ciência e a Tecnologia (FCT) (SFRH/BD/46929/ 2008 and PTDC/SAUESA/102367/2008). |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-07-01 2015-07-01T00:00:00Z 2023-05-26T22:22:13Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/153235 |
| url |
http://hdl.handle.net/10362/153235 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0267-8357 PURE: 61679345 https://doi.org/10.1093/mutage/gev002 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
11 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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|
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1799138140069298176 |