Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/3173 |
Resumo: | Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours. |
id |
RCAP_971c62397c26d37ef629e3537161c10a |
---|---|
oai_identifier_str |
oai:recipp.ipp.pt:10400.22/3173 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
|
spelling |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumoursSialyl:TnBladder cancerGlycosylationST6GalNAc.ITumour-associated glycansproliferative bladder cancerLittle is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours.ElsevierRepositório Científico do Instituto Politécnico do PortoFerreira, José AlexandreVideira, PaulaLima, LuísPereira, SofiaSilva, MarianaCarrascal, MileneSeverino, PauloFernandes, ElisabeteAlmeida, AndreiaCosta, CéuVitorino, RuiAmaro, TeresinaOliveira, Maria JoséReis, CelsoDall'Olio, FabioAmado, FranciscoSantos, Lúcio2014-01-01T14:02:42Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/3173eng10.1016/j.molonc.2013.03.001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:42:58ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
title |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
spellingShingle |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours Ferreira, José Alexandre Sialyl:Tn Bladder cancer Glycosylation ST6GalNAc.I Tumour-associated glycans proliferative bladder cancer |
title_short |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
title_full |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
title_fullStr |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
title_full_unstemmed |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
title_sort |
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours |
author |
Ferreira, José Alexandre |
author_facet |
Ferreira, José Alexandre Videira, Paula Lima, Luís Pereira, Sofia Silva, Mariana Carrascal, Milene Severino, Paulo Fernandes, Elisabete Almeida, Andreia Costa, Céu Vitorino, Rui Amaro, Teresina Oliveira, Maria José Reis, Celso Dall'Olio, Fabio Amado, Francisco Santos, Lúcio |
author_role |
author |
author2 |
Videira, Paula Lima, Luís Pereira, Sofia Silva, Mariana Carrascal, Milene Severino, Paulo Fernandes, Elisabete Almeida, Andreia Costa, Céu Vitorino, Rui Amaro, Teresina Oliveira, Maria José Reis, Celso Dall'Olio, Fabio Amado, Francisco Santos, Lúcio |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Ferreira, José Alexandre Videira, Paula Lima, Luís Pereira, Sofia Silva, Mariana Carrascal, Milene Severino, Paulo Fernandes, Elisabete Almeida, Andreia Costa, Céu Vitorino, Rui Amaro, Teresina Oliveira, Maria José Reis, Celso Dall'Olio, Fabio Amado, Francisco Santos, Lúcio |
dc.subject.por.fl_str_mv |
Sialyl:Tn Bladder cancer Glycosylation ST6GalNAc.I Tumour-associated glycans proliferative bladder cancer |
topic |
Sialyl:Tn Bladder cancer Glycosylation ST6GalNAc.I Tumour-associated glycans proliferative bladder cancer |
description |
Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2013-01-01T00:00:00Z 2014-01-01T14:02:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/3173 |
url |
http://hdl.handle.net/10400.22/3173 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.molonc.2013.03.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1777302292378157056 |