The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

Detalhes bibliográficos
Autor(a) principal: Ferreira, José Augusto
Data de Publicação: 2017
Outros Autores: Gonçalves, Lino, Naghipoor, Jahed, Oliveira, Paula de, Rabczuk, Timon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/45373
https://doi.org/10.1016/j.mbs.2016.11.005
Resumo: In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.
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spelling The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stentsAbsorbable ImplantsAntineoplastic AgentsArteriesPaclitaxelPlaque, AtheroscleroticSirolimusDrug-Eluting StentsModels, TheoreticalIn this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.Elsevier2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/45373http://hdl.handle.net/10316/45373https://doi.org/10.1016/j.mbs.2016.11.005https://doi.org/10.1016/j.mbs.2016.11.005enghttps://doi.org/10.1016/j.mbs.2016.11.005Ferreira, José AugustoGonçalves, LinoNaghipoor, JahedOliveira, Paula deRabczuk, Timoninfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-06-29T10:03:03Zoai:estudogeral.uc.pt:10316/45373Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:24.377664Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
spellingShingle The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
Ferreira, José Augusto
Absorbable Implants
Antineoplastic Agents
Arteries
Paclitaxel
Plaque, Atherosclerotic
Sirolimus
Drug-Eluting Stents
Models, Theoretical
title_short The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_full The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_fullStr The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_full_unstemmed The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
title_sort The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents
author Ferreira, José Augusto
author_facet Ferreira, José Augusto
Gonçalves, Lino
Naghipoor, Jahed
Oliveira, Paula de
Rabczuk, Timon
author_role author
author2 Gonçalves, Lino
Naghipoor, Jahed
Oliveira, Paula de
Rabczuk, Timon
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, José Augusto
Gonçalves, Lino
Naghipoor, Jahed
Oliveira, Paula de
Rabczuk, Timon
dc.subject.por.fl_str_mv Absorbable Implants
Antineoplastic Agents
Arteries
Paclitaxel
Plaque, Atherosclerotic
Sirolimus
Drug-Eluting Stents
Models, Theoretical
topic Absorbable Implants
Antineoplastic Agents
Arteries
Paclitaxel
Plaque, Atherosclerotic
Sirolimus
Drug-Eluting Stents
Models, Theoretical
description In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/45373
http://hdl.handle.net/10316/45373
https://doi.org/10.1016/j.mbs.2016.11.005
https://doi.org/10.1016/j.mbs.2016.11.005
url http://hdl.handle.net/10316/45373
https://doi.org/10.1016/j.mbs.2016.11.005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.mbs.2016.11.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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