COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity

• Autor(a) principal: David, Suzana
• Data de Publicação: 2022
• Outros Autores: Dorado, Guillermo, Duarte, Elsa Leclerc, David-Bosne, Stephanie, Trigueiro-Louro, João, Rebelo de Andrade, Helena
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10174/32321; https://doi.org/David, S., Dorado, G., Duarte, E.L. et al. COVID-19: impact on Public Health and hypothesis-driven investigations on genetic susceptibility and severity. Immunogenetics (2022). https://doi.org/10.1007/s00251-022-01261-w; https://doi.org/10.1007/s00251-022-01261-w
• topic: Candidate gene association studies (CGAS); COVID19; Public Health; susceptibility to infection; Genome-wide association studies (GWAS); Genetic determinants of severe disease

COVID-19 is a new complex multisystem disease caused by the novel coronavirus SARS-CoV-2. In slightly over 2 years, it infected nearly 500 million and killed 6 million human beings worldwide, causing an unprecedented coronavirus pandemic. Currently, the international scientific community is engaged in elucidating the molecular mechanisms of the pathophysiology of SARS-CoV-2 infection as a basis of scientific developments for the future control of COVID-19. Global exome and genome analysis efforts work to define the human genetics of protective immunity to SARS-CoV-2 infection. Here, we review the current knowledge regarding the SARS-CoV-2 infection, the implications of COVID-19 to Public Health and discuss genotype to phenotype association approaches that could be exploited through the selection of candidate genes to identify the genetic determinants of severe COVID-19.