Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine

Detalhes bibliográficos
Autor(a) principal: Alpuim Costa, Diogo
Data de Publicação: 2021
Outros Autores: Gonçalves Nobre, José Guilherme, Batista, Marta Vaz, Ribeiro, Catarina, Calle, Catarina, Cortes, Alfonso, Marhold, Maximilian, Negreiros, Ida, Borralho, Paula, Brito, Miguel, Braga, Sofia Azambuja, Costa, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46987
Resumo: Copyright © 2021 Alpuim Costa, Nobre, Batista, Ribeiro, Calle, Cortes, Marhold, Negreiros, Borralho, Brito, Cortes, Braga and Costa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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spelling Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicineBreast cancerMicrobiotaMicrobiomeDysbiosisMetabolomicsPharmacomicrobiomicsPersonalized medicineReviewCopyright © 2021 Alpuim Costa, Nobre, Batista, Ribeiro, Calle, Cortes, Marhold, Negreiros, Borralho, Brito, Cortes, Braga and Costa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Breast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Recently, gut microbiota dysbiosis emerged as a key player that may directly and/or indirectly influence development, treatment, and prognosis of BC through diverse biological processes: host cell proliferation and death, immune system function, chronic inflammation, oncogenic signalling, hormonal and detoxification pathways. Gut colonisation occurs during the prenatal period and is later diversified over distinct phases throughout life. In newly diagnosed postmenopausal BC patients, an altered faecal microbiota composition has been observed compared with healthy controls. Particularly, β-glucuronidase bacteria seem to modulate the enterohepatic circulation of oestrogens and their resorption, increasing the risk of hormone-dependent BC. Moreover, active phytoestrogens, short-chain fatty acids, lithocholic acid, and cadaverine have been identified as bacterial metabolites influencing the risk and prognosis of BC. As in gut, links are also being made with local microbiota of tumoural and healthy breast tissues. In breast microbiota, different microbial signatures have been reported, with distinct patterns per stage and biological subtype. Total bacterial DNA load was lower in tumour tissue and advanced-stage BC when compared with healthy tissue and early stage BC, respectively. Hypothetically, these findings reflect local dysbiosis, potentially creating an environment that favours breast tumour carcinogenesis (oncogenic trigger), or the natural selection of microorganisms adapted to a specific microenvironment. In this review, we discuss the origin, composition, and dynamic evolution of human microbiota, the links between gut/breast microbiota and BC, and explore the potential implications of metabolomics and pharmacomicrobiomics that might impact BC development and treatment choices toward a more personalised medicine. Finally, we put in perspective the potential limitations and biases regarding the current microbiota research and provide new horizons for stronger accurate translational and clinical studies that are needed to better elucidate the complex network of interactions between host, microorganisms, and drugs in the field of BC.FrontiersRepositório da Universidade de LisboaAlpuim Costa, DiogoGonçalves Nobre, José GuilhermeBatista, Marta VazRibeiro, CatarinaCalle, CatarinaCortes, AlfonsoMarhold, MaximilianNegreiros, IdaBorralho, PaulaBrito, MiguelBraga, Sofia AzambujaCosta, Luis2021-03-23T13:33:04Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46987engFront Microbiol. 2021 Feb 25;12:58433210.3389/fmicb.2021.5843321664-302Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:34Zoai:repositorio.ul.pt:10451/46987Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:04.977408Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
title Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
spellingShingle Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
Alpuim Costa, Diogo
Breast cancer
Microbiota
Microbiome
Dysbiosis
Metabolomics
Pharmacomicrobiomics
Personalized medicine
Review
title_short Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
title_full Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
title_fullStr Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
title_full_unstemmed Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
title_sort Human microbiota and breast cancer : is there any relevant link? A literature review and new horizons toward personalised medicine
author Alpuim Costa, Diogo
author_facet Alpuim Costa, Diogo
Gonçalves Nobre, José Guilherme
Batista, Marta Vaz
Ribeiro, Catarina
Calle, Catarina
Cortes, Alfonso
Marhold, Maximilian
Negreiros, Ida
Borralho, Paula
Brito, Miguel
Braga, Sofia Azambuja
Costa, Luis
author_role author
author2 Gonçalves Nobre, José Guilherme
Batista, Marta Vaz
Ribeiro, Catarina
Calle, Catarina
Cortes, Alfonso
Marhold, Maximilian
Negreiros, Ida
Borralho, Paula
Brito, Miguel
Braga, Sofia Azambuja
Costa, Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Alpuim Costa, Diogo
Gonçalves Nobre, José Guilherme
Batista, Marta Vaz
Ribeiro, Catarina
Calle, Catarina
Cortes, Alfonso
Marhold, Maximilian
Negreiros, Ida
Borralho, Paula
Brito, Miguel
Braga, Sofia Azambuja
Costa, Luis
dc.subject.por.fl_str_mv Breast cancer
Microbiota
Microbiome
Dysbiosis
Metabolomics
Pharmacomicrobiomics
Personalized medicine
Review
topic Breast cancer
Microbiota
Microbiome
Dysbiosis
Metabolomics
Pharmacomicrobiomics
Personalized medicine
Review
description Copyright © 2021 Alpuim Costa, Nobre, Batista, Ribeiro, Calle, Cortes, Marhold, Negreiros, Borralho, Brito, Cortes, Braga and Costa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-23T13:33:04Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46987
url http://hdl.handle.net/10451/46987
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Microbiol. 2021 Feb 25;12:584332
10.3389/fmicb.2021.584332
1664-302X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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