Editorial: Breakthroughs in top-down proteomics

Detalhes bibliográficos
Autor(a) principal: Penque, Deborah
Data de Publicação: 2018
Outros Autores: Marcus, Katrin, Torres, Vukosaca Milic
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5435
Resumo: In this special issue, an updated overview on ‘where we are and where we are going in the area of top-down proteomics’ is given by Fornelli et al., one of the pioneering groups in top-down proteomics led by the proponent head of the term ‘proteoform’ and founder of the international Consortium in Top-Down Proteomics (CTDP), Neil Kelleher. Although being still technologically challenging, the rapid advances over the past years have demonstrated that the identification and characterization of thousands of proteoforms in high-throughput mode is today feasible for intact proteins< 30 kDa under denaturing condition. To further advance, the development of a new generation of instruments and softwares is still necessary, which may happen in the next coming years as predicted by the authors. The high molecular weight capability of native-top down proteomics, used today to characterize purified protein complexes under non-denaturing condition, is one of these technologies that could be innovated for high throughput top-down purposes. The main driver for this breakthrough is undoubtedly the wider acceptance and application of top-down approaches by proteomic researchers. This journey is already under way, as evidenced by the different articles presented in this special issue.
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spelling Editorial: Breakthroughs in top-down proteomicsProteomicsBiomarkersGenómica Funcional e EstruturalGenómica FuncionalIn this special issue, an updated overview on ‘where we are and where we are going in the area of top-down proteomics’ is given by Fornelli et al., one of the pioneering groups in top-down proteomics led by the proponent head of the term ‘proteoform’ and founder of the international Consortium in Top-Down Proteomics (CTDP), Neil Kelleher. Although being still technologically challenging, the rapid advances over the past years have demonstrated that the identification and characterization of thousands of proteoforms in high-throughput mode is today feasible for intact proteins< 30 kDa under denaturing condition. To further advance, the development of a new generation of instruments and softwares is still necessary, which may happen in the next coming years as predicted by the authors. The high molecular weight capability of native-top down proteomics, used today to characterize purified protein complexes under non-denaturing condition, is one of these technologies that could be innovated for high throughput top-down purposes. The main driver for this breakthrough is undoubtedly the wider acceptance and application of top-down approaches by proteomic researchers. This journey is already under way, as evidenced by the different articles presented in this special issue.Elsevier/European Proteomics Association (EuPA)Repositório Científico do Instituto Nacional de SaúdePenque, DeborahMarcus, KatrinTorres, Vukosaca Milic2021-03-21T01:30:11Z2018-032018-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5435engJ Proteomics. 2018 Mar 20;175:1-2. doi: 10.1016/j.jprot.2017.12.011. Epub 2017 Dec 21.1874-391910.1016/j.jprot.2017.12.011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:51Zoai:repositorio.insa.pt:10400.18/5435Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:07.594363Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Editorial: Breakthroughs in top-down proteomics
title Editorial: Breakthroughs in top-down proteomics
spellingShingle Editorial: Breakthroughs in top-down proteomics
Penque, Deborah
Proteomics
Biomarkers
Genómica Funcional e Estrutural
Genómica Funcional
title_short Editorial: Breakthroughs in top-down proteomics
title_full Editorial: Breakthroughs in top-down proteomics
title_fullStr Editorial: Breakthroughs in top-down proteomics
title_full_unstemmed Editorial: Breakthroughs in top-down proteomics
title_sort Editorial: Breakthroughs in top-down proteomics
author Penque, Deborah
author_facet Penque, Deborah
Marcus, Katrin
Torres, Vukosaca Milic
author_role author
author2 Marcus, Katrin
Torres, Vukosaca Milic
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Penque, Deborah
Marcus, Katrin
Torres, Vukosaca Milic
dc.subject.por.fl_str_mv Proteomics
Biomarkers
Genómica Funcional e Estrutural
Genómica Funcional
topic Proteomics
Biomarkers
Genómica Funcional e Estrutural
Genómica Funcional
description In this special issue, an updated overview on ‘where we are and where we are going in the area of top-down proteomics’ is given by Fornelli et al., one of the pioneering groups in top-down proteomics led by the proponent head of the term ‘proteoform’ and founder of the international Consortium in Top-Down Proteomics (CTDP), Neil Kelleher. Although being still technologically challenging, the rapid advances over the past years have demonstrated that the identification and characterization of thousands of proteoforms in high-throughput mode is today feasible for intact proteins< 30 kDa under denaturing condition. To further advance, the development of a new generation of instruments and softwares is still necessary, which may happen in the next coming years as predicted by the authors. The high molecular weight capability of native-top down proteomics, used today to characterize purified protein complexes under non-denaturing condition, is one of these technologies that could be innovated for high throughput top-down purposes. The main driver for this breakthrough is undoubtedly the wider acceptance and application of top-down approaches by proteomic researchers. This journey is already under way, as evidenced by the different articles presented in this special issue.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
2018-03-01T00:00:00Z
2021-03-21T01:30:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5435
url http://hdl.handle.net/10400.18/5435
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Proteomics. 2018 Mar 20;175:1-2. doi: 10.1016/j.jprot.2017.12.011. Epub 2017 Dec 21.
1874-3919
10.1016/j.jprot.2017.12.011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier/European Proteomics Association (EuPA)
publisher.none.fl_str_mv Elsevier/European Proteomics Association (EuPA)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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