Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy

Detalhes bibliográficos
Autor(a) principal: Wei, Hong
Data de Publicação: 2013
Outros Autores: Viisanen, Hanna, Amorim, Diana, Koivisto, Ari, Pertovaara, Antti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/32930
Resumo: Uncorrected proof
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spelling Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathyChembridge-5861528ClonidineConditioned place-preferenceDiabetic neuropathyMechanical hypersensitivityOngoing painPeripheral nerve injuryTransient receptor potential ankyrin 1 channelScience & TechnologyUncorrected proofTransient receptor potential ankyrin 1 (TRPA1) channel antagonists have suppressed mechanical hypersensitivity in peripheral neuropathy, while their effect on ongoing neuropathic pain is not yet known. Here, we assessed whether blocking the TRPA1 channel induces place-preference, an index for the relief of ongoing pain, in two experimental rat models of peripheral neuropathy. Diabetic neuropathy was induced by streptozotocin and spared nerve injury (SNI) model of neuropathy by ligation of two sciatic nerve branches. Conditioned place-preference (CPP) paradigm involved pairing of the drug treatment with one of the chambers of a CPP device once or four times, and the time spent in each chamber was recorded after conditioning sessions to reveal place-preference. The mechanical antihypersensitivity effect was assessed by the monofilament test immediately after the conditioning sessions. Intraperitoneally (30mg/kg; diabetic and SNI model) or intrathecally (10µg; diabetic model) administered Chembridge-5861528 (CHEM) was used as a selective TRPA1 channel antagonist. In diabetic and SNI models of neuropathy, CHEM failed to induce CPP at a dose that significantly attenuated mechanical hypersensitivity, independent of the route of drug administration or number of successive conditioning sessions. Intrathecal clonidine (an a2-adrenoceptor agonist; 10µg), in contrast, induced CPP in SNI but not control animals. The results indicate that ongoing pain, as revealed by CPP, is less sensitive to treatment by the TRPA1 channel antagonist than mechanical hypersensitivity in peripheral neuropathy.One of the authors (A.K.) is an employee of the pharmaceutical company (OrionPharma, Finland) that has supported this study.The study was supported by the Sigrid Juselius Foundation, Helsinki, the Academy of Finland, Helsinki, and OrionPharma, Orion Corporation, Turku, Finland. Diana Amorim was supported by the Portuguese Science Foundation (FCT) grant SFRH/BD/71219/2010.ElsevierUniversidade do MinhoWei, HongViisanen, HannaAmorim, DianaKoivisto, AriPertovaara, Antti20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/32930eng0091-305710.1016/j.pbb.2012.12.01423287802www.elsevier.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:41:40Zoai:repositorium.sdum.uminho.pt:1822/32930Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:38:41.883679Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
title Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
spellingShingle Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
Wei, Hong
Chembridge-5861528
Clonidine
Conditioned place-preference
Diabetic neuropathy
Mechanical hypersensitivity
Ongoing pain
Peripheral nerve injury
Transient receptor potential ankyrin 1 channel
Science & Technology
title_short Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
title_full Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
title_fullStr Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
title_full_unstemmed Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
title_sort Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy
author Wei, Hong
author_facet Wei, Hong
Viisanen, Hanna
Amorim, Diana
Koivisto, Ari
Pertovaara, Antti
author_role author
author2 Viisanen, Hanna
Amorim, Diana
Koivisto, Ari
Pertovaara, Antti
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Wei, Hong
Viisanen, Hanna
Amorim, Diana
Koivisto, Ari
Pertovaara, Antti
dc.subject.por.fl_str_mv Chembridge-5861528
Clonidine
Conditioned place-preference
Diabetic neuropathy
Mechanical hypersensitivity
Ongoing pain
Peripheral nerve injury
Transient receptor potential ankyrin 1 channel
Science & Technology
topic Chembridge-5861528
Clonidine
Conditioned place-preference
Diabetic neuropathy
Mechanical hypersensitivity
Ongoing pain
Peripheral nerve injury
Transient receptor potential ankyrin 1 channel
Science & Technology
description Uncorrected proof
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/32930
url http://hdl.handle.net/1822/32930
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0091-3057
10.1016/j.pbb.2012.12.014
23287802
www.elsevier.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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