PINK1 : a bridge between mitochondria and Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Filipa
Data de Publicação: 2021
Outros Autores: Morais, Vanessa A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/48059
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling PINK1 : a bridge between mitochondria and Parkinson's diseasePINK1Parkinson’s diseaseMitochondria homeostasis© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Mitochondria are known as highly dynamic organelles essential for energy production. Intriguingly, in the recent years, mitochondria have revealed the ability to maintain cell homeostasis and ultimately regulate cell fate. This regulation is achieved by evoking mitochondrial quality control pathways that are capable of sensing the overall status of the cellular environment. In a first instance, actions to maintain a robust pool of mitochondria take place; however, if unsuccessful, measures that lead to overall cell death occur. One of the central key players of these mitochondrial quality control pathways is PINK1 (PTEN-induce putative kinase), a mitochondrial targeted kinase. PINK1 is known to interact with several substrates to regulate mitochondrial functions, and not only is responsible for triggering mitochondrial clearance via mitophagy, but also participates in maintenance of mitochondrial functions and homeostasis, under healthy conditions. Moreover, PINK1 has been associated with the familial form of Parkinson’s disease (PD). Growing evidence has strongly linked mitochondrial homeostasis to the central nervous system (CNS), a system that is replenished with high energy demanding long-lasting neuronal cells. Moreover, sporadic cases of PD have also revealed mitochondrial impairments. Thus, one could speculate that mitochondrial homeostasis is the common denominator in these two forms of the disease, and PINK1 may play a central role in maintaining mitochondrial homeostasis. In this review, we will discuss the role of PINK1 in the mitochondrial physiology and scrutinize its role in the cascade of PD pathology.The authors are supported by Fundação para a Ciência e Tecnologia, Grant references for FBG SFRH/BD/134316/2017, VAM IF/01693/2014, Funding reference: PTDC/BIA-CEL/31230/2017 by Fundação para a Ciência e a Tecnologia (FCT); ERC-StG-679168 by European Research Council; and EMBO-IG/3309 by European Molecular Biology Organization.MDPIRepositório da Universidade de LisboaGonçalves, FilipaMorais, Vanessa A.2021-05-20T16:04:49Z2021-04-212021-04-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48059engLife (Basel). 2021 Apr 21;11(5):37110.3390/life110503712075-1729info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:16Zoai:repositorio.ul.pt:10451/48059Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:59.137377Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PINK1 : a bridge between mitochondria and Parkinson's disease
title PINK1 : a bridge between mitochondria and Parkinson's disease
spellingShingle PINK1 : a bridge between mitochondria and Parkinson's disease
Gonçalves, Filipa
PINK1
Parkinson’s disease
Mitochondria homeostasis
title_short PINK1 : a bridge between mitochondria and Parkinson's disease
title_full PINK1 : a bridge between mitochondria and Parkinson's disease
title_fullStr PINK1 : a bridge between mitochondria and Parkinson's disease
title_full_unstemmed PINK1 : a bridge between mitochondria and Parkinson's disease
title_sort PINK1 : a bridge between mitochondria and Parkinson's disease
author Gonçalves, Filipa
author_facet Gonçalves, Filipa
Morais, Vanessa A.
author_role author
author2 Morais, Vanessa A.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gonçalves, Filipa
Morais, Vanessa A.
dc.subject.por.fl_str_mv PINK1
Parkinson’s disease
Mitochondria homeostasis
topic PINK1
Parkinson’s disease
Mitochondria homeostasis
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-05-20T16:04:49Z
2021-04-21
2021-04-21T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/48059
url http://hdl.handle.net/10451/48059
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Life (Basel). 2021 Apr 21;11(5):371
10.3390/life11050371
2075-1729
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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