Bioinspired bone therapies using naringin: applications and advances

Detalhes bibliográficos
Autor(a) principal: Lavrador, Pedro
Data de Publicação: 2018
Outros Autores: Gaspar, Vítor M., Mano, João F
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/25873
Resumo: The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.
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spelling Bioinspired bone therapies using naringin: applications and advancesAnimalsBiocompatible MaterialsBone DiseasesBone and BonesFlavanonesHumansThe use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.Elsevier2019-06-01T00:00:00Z2018-06-01T00:00:00Z2018-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/25873eng1359-644610.1016/j.drudis.2018.05.012Lavrador, PedroGaspar, Vítor M.Mano, João Finfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:50:05Zoai:ria.ua.pt:10773/25873Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:58:59.976106Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bioinspired bone therapies using naringin: applications and advances
title Bioinspired bone therapies using naringin: applications and advances
spellingShingle Bioinspired bone therapies using naringin: applications and advances
Lavrador, Pedro
Animals
Biocompatible Materials
Bone Diseases
Bone and Bones
Flavanones
Humans
title_short Bioinspired bone therapies using naringin: applications and advances
title_full Bioinspired bone therapies using naringin: applications and advances
title_fullStr Bioinspired bone therapies using naringin: applications and advances
title_full_unstemmed Bioinspired bone therapies using naringin: applications and advances
title_sort Bioinspired bone therapies using naringin: applications and advances
author Lavrador, Pedro
author_facet Lavrador, Pedro
Gaspar, Vítor M.
Mano, João F
author_role author
author2 Gaspar, Vítor M.
Mano, João F
author2_role author
author
dc.contributor.author.fl_str_mv Lavrador, Pedro
Gaspar, Vítor M.
Mano, João F
dc.subject.por.fl_str_mv Animals
Biocompatible Materials
Bone Diseases
Bone and Bones
Flavanones
Humans
topic Animals
Biocompatible Materials
Bone Diseases
Bone and Bones
Flavanones
Humans
description The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.
publishDate 2018
dc.date.none.fl_str_mv 2018-06-01T00:00:00Z
2018-06
2019-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/25873
url http://hdl.handle.net/10773/25873
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1359-6446
10.1016/j.drudis.2018.05.012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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