O2 generation during neuromelanin synthesis. The action of manganese.

Detalhes bibliográficos
Autor(a) principal: Marinho, C R
Data de Publicação: 1993
Outros Autores: Manso, C F
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151
Resumo: The oxygen uptake during the reaction of dopamine autoxidation was studied and it was found that it may occur through two distinct oxidative pathways. One involves the univalent reduction of oxygen, forming the superoxide radical, the other involves a bivalent reduction which generates hydrogen peroxide. The detection of the univalent reaction was followed by the study of oxygen consumption, in the presence of cytochrome c. The detection of the bivalent reaction was made in the presence of catalase. It was found that manganese increases the oxygen uptake of the reaction, by increasing the production of both oxygen active forms. It seems probable that the neurotoxicity of this metal may be related with the increased production of activated oxygen in dopaminergic neurons, which undergo an oxidative stress.
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spelling O2 generation during neuromelanin synthesis. The action of manganese.Geração de O2 durante a síntese de neuromelaninas. Acção do manganésio.The oxygen uptake during the reaction of dopamine autoxidation was studied and it was found that it may occur through two distinct oxidative pathways. One involves the univalent reduction of oxygen, forming the superoxide radical, the other involves a bivalent reduction which generates hydrogen peroxide. The detection of the univalent reaction was followed by the study of oxygen consumption, in the presence of cytochrome c. The detection of the bivalent reaction was made in the presence of catalase. It was found that manganese increases the oxygen uptake of the reaction, by increasing the production of both oxygen active forms. It seems probable that the neurotoxicity of this metal may be related with the increased production of activated oxygen in dopaminergic neurons, which undergo an oxidative stress.The oxygen uptake during the reaction of dopamine autoxidation was studied and it was found that it may occur through two distinct oxidative pathways. One involves the univalent reduction of oxygen, forming the superoxide radical, the other involves a bivalent reduction which generates hydrogen peroxide. The detection of the univalent reaction was followed by the study of oxygen consumption, in the presence of cytochrome c. The detection of the bivalent reaction was made in the presence of catalase. It was found that manganese increases the oxygen uptake of the reaction, by increasing the production of both oxygen active forms. It seems probable that the neurotoxicity of this metal may be related with the increased production of activated oxygen in dopaminergic neurons, which undergo an oxidative stress.Ordem dos Médicos1993-11-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151oai:ojs.www.actamedicaportuguesa.com:article/3151Acta Médica Portuguesa; Vol. 6 No. 11 (1993): Novembro; 547-54Acta Médica Portuguesa; Vol. 6 N.º 11 (1993): Novembro; 547-541646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151/2490Marinho, C RManso, C Finfo:eu-repo/semantics/openAccess2022-12-20T11:01:42Zoai:ojs.www.actamedicaportuguesa.com:article/3151Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:10.993608Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv O2 generation during neuromelanin synthesis. The action of manganese.
Geração de O2 durante a síntese de neuromelaninas. Acção do manganésio.
title O2 generation during neuromelanin synthesis. The action of manganese.
spellingShingle O2 generation during neuromelanin synthesis. The action of manganese.
Marinho, C R
title_short O2 generation during neuromelanin synthesis. The action of manganese.
title_full O2 generation during neuromelanin synthesis. The action of manganese.
title_fullStr O2 generation during neuromelanin synthesis. The action of manganese.
title_full_unstemmed O2 generation during neuromelanin synthesis. The action of manganese.
title_sort O2 generation during neuromelanin synthesis. The action of manganese.
author Marinho, C R
author_facet Marinho, C R
Manso, C F
author_role author
author2 Manso, C F
author2_role author
dc.contributor.author.fl_str_mv Marinho, C R
Manso, C F
description The oxygen uptake during the reaction of dopamine autoxidation was studied and it was found that it may occur through two distinct oxidative pathways. One involves the univalent reduction of oxygen, forming the superoxide radical, the other involves a bivalent reduction which generates hydrogen peroxide. The detection of the univalent reaction was followed by the study of oxygen consumption, in the presence of cytochrome c. The detection of the bivalent reaction was made in the presence of catalase. It was found that manganese increases the oxygen uptake of the reaction, by increasing the production of both oxygen active forms. It seems probable that the neurotoxicity of this metal may be related with the increased production of activated oxygen in dopaminergic neurons, which undergo an oxidative stress.
publishDate 1993
dc.date.none.fl_str_mv 1993-11-30
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151
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dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3151/2490
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 6 No. 11 (1993): Novembro; 547-54
Acta Médica Portuguesa; Vol. 6 N.º 11 (1993): Novembro; 547-54
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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