Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/15545 https://doi.org/10.4061/2011/693761 |
Resumo: | While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease. Mitochondria are remarkably primed to play a vital role in neuronal cell survival since they are key regulators of energy metabolism (as ATP producers), of intracellular calcium homeostasis, of NAD+/NADH ratio, and of endogenous reactive oxygen species production and programmed cell death. In this paper, we focus on mitochondrial dysfunction-mediated alpha-synuclein aggregation. We highlight some of the findings that provide proof of evidence for a mitochondrial metabolism control in Parkinson's disease, namely, mitochondrial regulation of microtubule-dependent cellular traffic and autophagic lysosomal pathway. The knowledge that microtubule alterations may lead to autophagic deficiency and may compromise the cellular degradation mechanisms that culminate in the progressive accumulation of aberrant protein aggregates shields new insights to the way we address Parkinson's disease. In line with this knowledge, an innovative window for new therapeutic strategies aimed to restore microtubule network may be unlocked. |
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Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PDWhile the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease. Mitochondria are remarkably primed to play a vital role in neuronal cell survival since they are key regulators of energy metabolism (as ATP producers), of intracellular calcium homeostasis, of NAD+/NADH ratio, and of endogenous reactive oxygen species production and programmed cell death. In this paper, we focus on mitochondrial dysfunction-mediated alpha-synuclein aggregation. We highlight some of the findings that provide proof of evidence for a mitochondrial metabolism control in Parkinson's disease, namely, mitochondrial regulation of microtubule-dependent cellular traffic and autophagic lysosomal pathway. The knowledge that microtubule alterations may lead to autophagic deficiency and may compromise the cellular degradation mechanisms that culminate in the progressive accumulation of aberrant protein aggregates shields new insights to the way we address Parkinson's disease. In line with this knowledge, an innovative window for new therapeutic strategies aimed to restore microtubule network may be unlocked.Hindawi Publishing Corporation2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/15545http://hdl.handle.net/10316/15545https://doi.org/10.4061/2011/693761engESTEVES, A. R. [et al.] - Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. "Parkinson's Disease". ISSN 2042-0080. Vol. 2011 (2011) 20 p.2042-0080Esteves, A. R.Arduíno, D. M.Silva, D. F. F.Oliveira, C. R.Cardoso, S. M.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-12-01T17:20:03Zoai:estudogeral.uc.pt:10316/15545Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:53:33.882646Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
title |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
spellingShingle |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD Esteves, A. R. |
title_short |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
title_full |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
title_fullStr |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
title_full_unstemmed |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
title_sort |
Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD |
author |
Esteves, A. R. |
author_facet |
Esteves, A. R. Arduíno, D. M. Silva, D. F. F. Oliveira, C. R. Cardoso, S. M. |
author_role |
author |
author2 |
Arduíno, D. M. Silva, D. F. F. Oliveira, C. R. Cardoso, S. M. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Esteves, A. R. Arduíno, D. M. Silva, D. F. F. Oliveira, C. R. Cardoso, S. M. |
description |
While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease. Mitochondria are remarkably primed to play a vital role in neuronal cell survival since they are key regulators of energy metabolism (as ATP producers), of intracellular calcium homeostasis, of NAD+/NADH ratio, and of endogenous reactive oxygen species production and programmed cell death. In this paper, we focus on mitochondrial dysfunction-mediated alpha-synuclein aggregation. We highlight some of the findings that provide proof of evidence for a mitochondrial metabolism control in Parkinson's disease, namely, mitochondrial regulation of microtubule-dependent cellular traffic and autophagic lysosomal pathway. The knowledge that microtubule alterations may lead to autophagic deficiency and may compromise the cellular degradation mechanisms that culminate in the progressive accumulation of aberrant protein aggregates shields new insights to the way we address Parkinson's disease. In line with this knowledge, an innovative window for new therapeutic strategies aimed to restore microtubule network may be unlocked. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/15545 http://hdl.handle.net/10316/15545 https://doi.org/10.4061/2011/693761 |
url |
http://hdl.handle.net/10316/15545 https://doi.org/10.4061/2011/693761 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ESTEVES, A. R. [et al.] - Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. "Parkinson's Disease". ISSN 2042-0080. Vol. 2011 (2011) 20 p. 2042-0080 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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