An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.1387/ijdb.120008ah |
Resumo: | Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology. |
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7160 |
spelling |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissueDevelopmentExocytosisRab27Secretory RabSmall GTPaseDevelopmental BiologyEmbryologySDG 3 - Good Health and Well-beingRegulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHendrix, AnLambein, KathleenWestbroek, WendySeabra, Miguel C.Cocquyt, VeroniquePauwels, PatrickBracke, MarcGespach, ChristianDe Wever, Olivier2017-10-16T22:04:01Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttps://doi.org/10.1387/ijdb.120008aheng0214-6282PURE: 3217824http://www.scopus.com/inward/record.url?scp=84863797403&partnerID=8YFLogxKhttps://doi.org/10.1387/ijdb.120008ahinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:34Zoai:run.unl.pt:10362/24253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:01.264954Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
title |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
spellingShingle |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue Hendrix, An Development Exocytosis Rab27 Secretory Rab Small GTPase Developmental Biology Embryology SDG 3 - Good Health and Well-being |
title_short |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
title_full |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
title_fullStr |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
title_full_unstemmed |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
title_sort |
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue |
author |
Hendrix, An |
author_facet |
Hendrix, An Lambein, Kathleen Westbroek, Wendy Seabra, Miguel C. Cocquyt, Veronique Pauwels, Patrick Bracke, Marc Gespach, Christian De Wever, Olivier |
author_role |
author |
author2 |
Lambein, Kathleen Westbroek, Wendy Seabra, Miguel C. Cocquyt, Veronique Pauwels, Patrick Bracke, Marc Gespach, Christian De Wever, Olivier |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Hendrix, An Lambein, Kathleen Westbroek, Wendy Seabra, Miguel C. Cocquyt, Veronique Pauwels, Patrick Bracke, Marc Gespach, Christian De Wever, Olivier |
dc.subject.por.fl_str_mv |
Development Exocytosis Rab27 Secretory Rab Small GTPase Developmental Biology Embryology SDG 3 - Good Health and Well-being |
topic |
Development Exocytosis Rab27 Secretory Rab Small GTPase Developmental Biology Embryology SDG 3 - Good Health and Well-being |
description |
Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2012-01-01T00:00:00Z 2017-10-16T22:04:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1387/ijdb.120008ah |
url |
https://doi.org/10.1387/ijdb.120008ah |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0214-6282 PURE: 3217824 http://www.scopus.com/inward/record.url?scp=84863797403&partnerID=8YFLogxK https://doi.org/10.1387/ijdb.120008ah |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137907128139776 |