An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

Detalhes bibliográficos
Autor(a) principal: Hendrix, An
Data de Publicação: 2012
Outros Autores: Lambein, Kathleen, Westbroek, Wendy, Seabra, Miguel C., Cocquyt, Veronique, Pauwels, Patrick, Bracke, Marc, Gespach, Christian, De Wever, Olivier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1387/ijdb.120008ah
Resumo: Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.
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spelling An immunohistochemical analysis of Rab27B distribution in fetal and adult tissueDevelopmentExocytosisRab27Secretory RabSmall GTPaseDevelopmental BiologyEmbryologySDG 3 - Good Health and Well-beingRegulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHendrix, AnLambein, KathleenWestbroek, WendySeabra, Miguel C.Cocquyt, VeroniquePauwels, PatrickBracke, MarcGespach, ChristianDe Wever, Olivier2017-10-16T22:04:01Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttps://doi.org/10.1387/ijdb.120008aheng0214-6282PURE: 3217824http://www.scopus.com/inward/record.url?scp=84863797403&partnerID=8YFLogxKhttps://doi.org/10.1387/ijdb.120008ahinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:12:34Zoai:run.unl.pt:10362/24253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:01.264954Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
title An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
spellingShingle An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
Hendrix, An
Development
Exocytosis
Rab27
Secretory Rab
Small GTPase
Developmental Biology
Embryology
SDG 3 - Good Health and Well-being
title_short An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
title_full An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
title_fullStr An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
title_full_unstemmed An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
title_sort An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue
author Hendrix, An
author_facet Hendrix, An
Lambein, Kathleen
Westbroek, Wendy
Seabra, Miguel C.
Cocquyt, Veronique
Pauwels, Patrick
Bracke, Marc
Gespach, Christian
De Wever, Olivier
author_role author
author2 Lambein, Kathleen
Westbroek, Wendy
Seabra, Miguel C.
Cocquyt, Veronique
Pauwels, Patrick
Bracke, Marc
Gespach, Christian
De Wever, Olivier
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Hendrix, An
Lambein, Kathleen
Westbroek, Wendy
Seabra, Miguel C.
Cocquyt, Veronique
Pauwels, Patrick
Bracke, Marc
Gespach, Christian
De Wever, Olivier
dc.subject.por.fl_str_mv Development
Exocytosis
Rab27
Secretory Rab
Small GTPase
Developmental Biology
Embryology
SDG 3 - Good Health and Well-being
topic Development
Exocytosis
Rab27
Secretory Rab
Small GTPase
Developmental Biology
Embryology
SDG 3 - Good Health and Well-being
description Regulated secretory pathways coordinated by small Rab GTPases are critically involved in intercellular communications. Here, we report the expression and localization of Rab27B in developing and differentiated epithelial human tissues by immunohistochemistry. Rab27B is poorly expressed in fetal tissues suggesting that several developmental mechanisms involved in epithelial differentiation and functions are mediated by other secretory Rab GTPases, such as Rab27A or Rab3 family members. In adult tissues, Rab27B is expressed in a wide variety of differentiated secretory epithelial cells, including those lining the salivary gland, gastrointestinal, mammary and prostate tracts. The complex pattern of Rab27B expression indicates that dysregulation of Rab27B-mediated secretion may have profound implications for disease pathology.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2017-10-16T22:04:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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format article
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dc.identifier.uri.fl_str_mv https://doi.org/10.1387/ijdb.120008ah
url https://doi.org/10.1387/ijdb.120008ah
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0214-6282
PURE: 3217824
http://www.scopus.com/inward/record.url?scp=84863797403&partnerID=8YFLogxK
https://doi.org/10.1387/ijdb.120008ah
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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