Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs

Detalhes bibliográficos
Autor(a) principal: Neves, F.
Data de Publicação: 2015
Outros Autores: Abrantes, J., Almeida, T., de Matos, A.L., Costa, Paulo, Esteves, P.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3284
Resumo: Disponível em: www.ncbi.nlm.nih.gov/pmc/articles/pmid/26395994/
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spelling Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphsImmune SystemInterleukinsRabbitLagomorphaDoenças GenéticasDeterminantes da Saúde e da DoençaDisponível em: www.ncbi.nlm.nih.gov/pmc/articles/pmid/26395994/ILs, as essential innate immune modulators, are involved in an array of biological processes. In the European rabbit (Oryctolagus cuniculus) IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18 have been implicated in inflammatory processes and in the immune response against rabbit hemorrhagic disease virus and myxoma virus infections. In this study we characterized these ILs in six Lagomorpha species (European rabbit, pygmy rabbit, two cottontail rabbit species, European brown hare and American pika). Overall, these ILs are conserved between lagomorphs, including in their exon/intron structure. Most differences were observed between leporids and American pika. Indeed, when comparing both, some relevant differences were observed in American pika, such as the location of the stop codon in IL-1α and IL-2, the existence of a different transcript in IL8 and the number of cysteine residues in IL-1β. Changes at N-glycosylation motifs were also detected in IL-1, IL-10, IL-12B and IL-15. IL-1α is the protein that presents the highest evolutionary distances, which is in contrast to IL-12A where the distances between lagomorphs are the lowest. For all these ILs, sequences of human and European rabbit are more closely related than between human and mouse or European rabbit and mouse.Research Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::ImmunologyResearch Subject Categories::NATURAL SCIENCES::Biology::Cell and molecular biology::GeneticsFCT and North Portugal Regional Operational Programme 2007/2013 (ON.2) grants supported this work.International Endotoxin and Innate Immunity SocietyRepositório Científico do Instituto Nacional de SaúdeNeves, F.Abrantes, J.Almeida, T.de Matos, A.L.Costa, PauloEsteves, P.J.2016-02-12T16:44:44Z2015-09-212015-09-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3284engInnate Immun. 2015 Nov;21(8):787-801. doi: 10.1177/1753425915606209. Epub 2015 Sep 211753-425910.1177/1753425915606209info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:51ZPortal AgregadorONG
dc.title.none.fl_str_mv Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
title Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
spellingShingle Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
Neves, F.
Immune System
Interleukins
Rabbit
Lagomorpha
Doenças Genéticas
Determinantes da Saúde e da Doença
title_short Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
title_full Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
title_fullStr Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
title_full_unstemmed Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
title_sort Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
author Neves, F.
author_facet Neves, F.
Abrantes, J.
Almeida, T.
de Matos, A.L.
Costa, Paulo
Esteves, P.J.
author_role author
author2 Abrantes, J.
Almeida, T.
de Matos, A.L.
Costa, Paulo
Esteves, P.J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Neves, F.
Abrantes, J.
Almeida, T.
de Matos, A.L.
Costa, Paulo
Esteves, P.J.
dc.subject.por.fl_str_mv Immune System
Interleukins
Rabbit
Lagomorpha
Doenças Genéticas
Determinantes da Saúde e da Doença
topic Immune System
Interleukins
Rabbit
Lagomorpha
Doenças Genéticas
Determinantes da Saúde e da Doença
description Disponível em: www.ncbi.nlm.nih.gov/pmc/articles/pmid/26395994/
publishDate 2015
dc.date.none.fl_str_mv 2015-09-21
2015-09-21T00:00:00Z
2016-02-12T16:44:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3284
url http://hdl.handle.net/10400.18/3284
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Innate Immun. 2015 Nov;21(8):787-801. doi: 10.1177/1753425915606209. Epub 2015 Sep 21
1753-4259
10.1177/1753425915606209
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv International Endotoxin and Innate Immunity Society
publisher.none.fl_str_mv International Endotoxin and Innate Immunity Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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