A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/46664 |
Resumo: | Copyright © 2020 Cascão, Vidal, Carvalho, Lopes, Romão, Goncalves, Moita andFonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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A COVID-19 outbreak in a rheumatology department upon the early days of the pandemicCOVID-19Healthcare workers (HCW)Presymptomatic transmissionRheumatic patientsRheumatology practiceCopyright © 2020 Cascão, Vidal, Carvalho, Lopes, Romão, Goncalves, Moita andFonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Objectives: To describe our experience with a coronavirus disease 2019 (COVID-19) outbreak within a large rheumatology department early in the pandemic. Methods: Symptomatic and asymptomatic healthcare workers (HCWs) had a naso-oropharyngeal swab for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and were followed clinically. Reverse transcription polymerase-chain reaction (RT-PCR) was repeated to document cure, and serological response was assessed. Patients with risk contacts within the department in the 14 days preceding the outbreak were screened for COVID-19 symptoms. Results: 14/34 HCWs (41%; 40 ± 14 years, 71% female) tested positive for SARS-CoV-2, and 11/34 (32%) developed symptoms but were RT-PCR-negative. Half of RT-PCR-positive HCWs did not report fever, cough, or dyspnea before testing, which were absent in 3/14 cases (21%). Mild disease prevailed (79%), but 3 HCWs had moderate disease requiring further assessment, which excluded severe complications. Nevertheless, symptom duration (28 ± 18 days), viral shedding (31 ± 10 days post-symptom onset, range 15-51), and work absence (29 ± 28 days) were prolonged. 13/14 (93%) of RT-PCR-positive and none of the RT-PCR-negative HCWs had a positive humoral response Higher IgG indexes were observed in individuals over 50 years of age (14.5 ± 7.7 vs. 5.0 ± 4.4, p = 0.012). Of 617 rheumatic patients, 8 (1.3%) developed COVID-19 symptoms (1/8 hospitalization, 8/8 complete recovery), following a consultation/procedure with an asymptomatic (7/8) or mildly symptomatic (1/8) HCW. Conclusions: A COVID-19 outbreak can occur among HCWs and rheumatic patients, swiftly spreading over the presymptomatic stage. Mild disease without typical symptoms should be recognized and may evolve with delayed viral shedding, prolonged recovery, and adequate immune response in most individuals.FrontiersRepositório da Universidade de LisboaRomão, Vasco C.Oliveira Ramos, FilipaMachado, Ana RitaMartins, PatríciaBarreira, SofiaSilva-Dinis, JoanaGalaio, Luís MendonçaProença, HelenaCristino, José MeloLeite, EmaKhmelinskii, NikitaRomeu, JoséFonseca, João Eurico2021-03-04T18:06:58Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46664engFront Med. 2020 Sep 25;7:576162.2095-021710.3389/fmed.2020.5761622095-0225info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:05Zoai:repositorio.ul.pt:10451/46664Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:47.674939Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| title |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| spellingShingle |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic Romão, Vasco C. COVID-19 Healthcare workers (HCW) Presymptomatic transmission Rheumatic patients Rheumatology practice |
| title_short |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| title_full |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| title_fullStr |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| title_full_unstemmed |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| title_sort |
A COVID-19 outbreak in a rheumatology department upon the early days of the pandemic |
| author |
Romão, Vasco C. |
| author_facet |
Romão, Vasco C. Oliveira Ramos, Filipa Machado, Ana Rita Martins, Patrícia Barreira, Sofia Silva-Dinis, Joana Galaio, Luís Mendonça Proença, Helena Cristino, José Melo Leite, Ema Khmelinskii, Nikita Romeu, José Fonseca, João Eurico |
| author_role |
author |
| author2 |
Oliveira Ramos, Filipa Machado, Ana Rita Martins, Patrícia Barreira, Sofia Silva-Dinis, Joana Galaio, Luís Mendonça Proença, Helena Cristino, José Melo Leite, Ema Khmelinskii, Nikita Romeu, José Fonseca, João Eurico |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Romão, Vasco C. Oliveira Ramos, Filipa Machado, Ana Rita Martins, Patrícia Barreira, Sofia Silva-Dinis, Joana Galaio, Luís Mendonça Proença, Helena Cristino, José Melo Leite, Ema Khmelinskii, Nikita Romeu, José Fonseca, João Eurico |
| dc.subject.por.fl_str_mv |
COVID-19 Healthcare workers (HCW) Presymptomatic transmission Rheumatic patients Rheumatology practice |
| topic |
COVID-19 Healthcare workers (HCW) Presymptomatic transmission Rheumatic patients Rheumatology practice |
| description |
Copyright © 2020 Cascão, Vidal, Carvalho, Lopes, Romão, Goncalves, Moita andFonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-03-04T18:06:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/46664 |
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http://hdl.handle.net/10451/46664 |
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eng |
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eng |
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Front Med. 2020 Sep 25;7:576162. 2095-0217 10.3389/fmed.2020.576162 2095-0225 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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