Polymorphisms in base excision repair genes and thyroid cancer risk

Detalhes bibliográficos
Autor(a) principal: Santos, Luís Silva
Data de Publicação: 2012
Outros Autores: Silva, Susana N., Azevedo, Ana Paula da Silva, Rueff, Jose, Gaspar, Jorge F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/32889
Resumo: We wish to thank Luisa Manso Oliveira, Lylliane Luz, Silvia Morgado Amaro and Maria Catarina Soveral for technical support. This study was supported by the Center for Research in Human Molecular Genetics (CIGMH), Projects PTDC/SAU-OSM/105572/2008, PTDC/SAU-ESA/102367/2008 and PTDC/QUI/67522/2006 from Fundacao para a Ciencia e Tecnologia (FCT) and Fundacao Calouste Gulbenkian (Grant 76438/2006). The grants to M. Pingarilho (SFRH/BD/22612/2005) from FCT are also acknowledged
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spelling Polymorphisms in base excision repair genes and thyroid cancer riskDNA base excision repairXRCC1 POLYMORPHISMSSNPs polymorphismsBREAST-CANCERCARCINOMAASSOCIATIONSUSCEPTIBILITYMUTYH-ASSOCIATED POLYPOSIScancer susceptibilitythyroid cancerDNA-REPAIRJAPANESE POPULATIONPATHWAY GENESCOMMON VARIANTSSDG 3 - Good Health and Well-beingWe wish to thank Luisa Manso Oliveira, Lylliane Luz, Silvia Morgado Amaro and Maria Catarina Soveral for technical support. This study was supported by the Center for Research in Human Molecular Genetics (CIGMH), Projects PTDC/SAU-OSM/105572/2008, PTDC/SAU-ESA/102367/2008 and PTDC/QUI/67522/2006 from Fundacao para a Ciencia e Tecnologia (FCT) and Fundacao Calouste Gulbenkian (Grant 76438/2006). The grants to M. Pingarilho (SFRH/BD/22612/2005) from FCT are also acknowledgedThyroid cancer (TC) is the most frequent endocrine malignancy, accounting however for only 1-2\% of all human cancers, and tilt: best-established risk factor for TC is radiation exposure, particularly during childhood. Since the BER pathway seems to play an important role in the repair of DNA damage induced by IR and other genotoxicants, we carried out a hospital-based case-control study in order to evaluate the potential modifying role of 6 BER polymorphisms on the individual susceptibility to non-familial TC in 109 TC patients receiving iodine-131, and 217 controls matched for age ( 2 years), gender and ethnicity. Our results do not reveal a significant involvement of XRCCI Arg194Trp and Arg399Gln, OGGI Ser326Cys, APEXI Asp148Glu, MUTYH Gln335His and,PARPI Val762Ala polymorphisms on the individual susceptibility towards TC, mostly in aggreement with the limited available evidence. By histological stratification analyis, we observed that the association between the presence of heterozygozity in the MUTYH Gln335His polymorphism and TC risk almost reached significance for the papillary subtype of TC. This was the first time that the putative association between this polymorphism and TC susceptibility was evaluated. However, since the sample size was modest, the possibility of a type I error should not be excluded and this result should, therefore, be interpreted with caution. More in depth studies involving larger populations should be pursued in order to further clarify the potential usefulness of the MUTYH Gln335His genotype as a predictive biomarker of susceptibility to TC and the role of the remaining BER polymorphisms on TC susceptibility.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSantos, Luís SilvaSilva, Susana N.Azevedo, Ana Paula da SilvaRueff, JoseGaspar, Jorge F.2018-03-20T23:00:53Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/32889eng1021-335XPURE: 155887https://doi.org/10.3892/or.2012.1975info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-23T01:37:41Zoai:run.unl.pt:10362/32889Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-23T01:37:41Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polymorphisms in base excision repair genes and thyroid cancer risk
title Polymorphisms in base excision repair genes and thyroid cancer risk
spellingShingle Polymorphisms in base excision repair genes and thyroid cancer risk
Santos, Luís Silva
DNA base excision repair
XRCC1 POLYMORPHISMS
SNPs polymorphisms
BREAST-CANCER
CARCINOMA
ASSOCIATION
SUSCEPTIBILITY
MUTYH-ASSOCIATED POLYPOSIS
cancer susceptibility
thyroid cancer
DNA-REPAIR
JAPANESE POPULATION
PATHWAY GENES
COMMON VARIANTS
SDG 3 - Good Health and Well-being
title_short Polymorphisms in base excision repair genes and thyroid cancer risk
title_full Polymorphisms in base excision repair genes and thyroid cancer risk
title_fullStr Polymorphisms in base excision repair genes and thyroid cancer risk
title_full_unstemmed Polymorphisms in base excision repair genes and thyroid cancer risk
title_sort Polymorphisms in base excision repair genes and thyroid cancer risk
author Santos, Luís Silva
author_facet Santos, Luís Silva
Silva, Susana N.
Azevedo, Ana Paula da Silva
Rueff, Jose
Gaspar, Jorge F.
author_role author
author2 Silva, Susana N.
Azevedo, Ana Paula da Silva
Rueff, Jose
Gaspar, Jorge F.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Santos, Luís Silva
Silva, Susana N.
Azevedo, Ana Paula da Silva
Rueff, Jose
Gaspar, Jorge F.
dc.subject.por.fl_str_mv DNA base excision repair
XRCC1 POLYMORPHISMS
SNPs polymorphisms
BREAST-CANCER
CARCINOMA
ASSOCIATION
SUSCEPTIBILITY
MUTYH-ASSOCIATED POLYPOSIS
cancer susceptibility
thyroid cancer
DNA-REPAIR
JAPANESE POPULATION
PATHWAY GENES
COMMON VARIANTS
SDG 3 - Good Health and Well-being
topic DNA base excision repair
XRCC1 POLYMORPHISMS
SNPs polymorphisms
BREAST-CANCER
CARCINOMA
ASSOCIATION
SUSCEPTIBILITY
MUTYH-ASSOCIATED POLYPOSIS
cancer susceptibility
thyroid cancer
DNA-REPAIR
JAPANESE POPULATION
PATHWAY GENES
COMMON VARIANTS
SDG 3 - Good Health and Well-being
description We wish to thank Luisa Manso Oliveira, Lylliane Luz, Silvia Morgado Amaro and Maria Catarina Soveral for technical support. This study was supported by the Center for Research in Human Molecular Genetics (CIGMH), Projects PTDC/SAU-OSM/105572/2008, PTDC/SAU-ESA/102367/2008 and PTDC/QUI/67522/2006 from Fundacao para a Ciencia e Tecnologia (FCT) and Fundacao Calouste Gulbenkian (Grant 76438/2006). The grants to M. Pingarilho (SFRH/BD/22612/2005) from FCT are also acknowledged
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2018-03-20T23:00:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/32889
url http://hdl.handle.net/10362/32889
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1021-335X
PURE: 155887
https://doi.org/10.3892/or.2012.1975
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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