Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery

Detalhes bibliográficos
Autor(a) principal: Duarte, Ana Rita C.
Data de Publicação: 2006
Outros Autores: Casimiro, T., Duarte, A. A., Simplicio, A. L., Duarte, Catarina M. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/17596
Resumo: Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.
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spelling Supercritical polymerization and impregnation of molecularly imprinted polymers for drug deliveryHerein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.Universidade do MinhoDuarte, Ana Rita C.Casimiro, T.Duarte, A. A.Simplicio, A. L.Duarte, Catarina M. M.20062006-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/17596eng0896-8446info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:12:08Zoai:repositorium.sdum.uminho.pt:1822/17596Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:04:02.088117Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
title Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
spellingShingle Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
Duarte, Ana Rita C.
title_short Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
title_full Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
title_fullStr Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
title_full_unstemmed Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
title_sort Supercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
author Duarte, Ana Rita C.
author_facet Duarte, Ana Rita C.
Casimiro, T.
Duarte, A. A.
Simplicio, A. L.
Duarte, Catarina M. M.
author_role author
author2 Casimiro, T.
Duarte, A. A.
Simplicio, A. L.
Duarte, Catarina M. M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Duarte, Ana Rita C.
Casimiro, T.
Duarte, A. A.
Simplicio, A. L.
Duarte, Catarina M. M.
description Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.
publishDate 2006
dc.date.none.fl_str_mv 2006
2006-01-01T00:00:00Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/17596
url http://hdl.handle.net/1822/17596
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0896-8446
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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