Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study

Detalhes bibliográficos
Autor(a) principal: Pista, Angela
Data de Publicação: 2013
Outros Autores: de Oliveira, Carlos F., Lopes, Carlos, Cunha, Maria João, CLEOPATRE Portugal Study Groupa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/2163
Resumo: Collaborators (54): Tavares A, Dias M, Rocha E, Telhado Mda C, Afonso A, Loureiro M, Horgan C, Marques I, Cortes E, Alegra S, Serra Mdo C, Lima J, Afonso E, Ladeíra AP, Gonçalves L, Sobral N, Reforço AS, Pacheco MA, Enriquez JL, Lagoa A, Ribeiro V, Ferreira L, Cadilla AJ, Furtado JM, Rodrigues J, de Castro PV, e Silva AA, Mota F, Moura P, da Silva TS, Jardim O, Nascimento M, Dacosta A, Borrego J, Fernandes R, Vitorino A, Paula T, Palma F, Paula M, Fatela A, Sobral D, Pereira P, Grilo I, Ambrosio P, Torrezão I, Biscaia I, Nunes S, Araújo M, Sâncio S, Valente G, Mendonça S, Verdasca N, Oliveira A, Santos S.
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spelling Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II StudyCancerEpidemiologyCervical Intraepithelial NeoplasiaHPVPortugalCleopatreInfecções Sexualmente TransmissíveisCollaborators (54): Tavares A, Dias M, Rocha E, Telhado Mda C, Afonso A, Loureiro M, Horgan C, Marques I, Cortes E, Alegra S, Serra Mdo C, Lima J, Afonso E, Ladeíra AP, Gonçalves L, Sobral N, Reforço AS, Pacheco MA, Enriquez JL, Lagoa A, Ribeiro V, Ferreira L, Cadilla AJ, Furtado JM, Rodrigues J, de Castro PV, e Silva AA, Mota F, Moura P, da Silva TS, Jardim O, Nascimento M, Dacosta A, Borrego J, Fernandes R, Vitorino A, Paula T, Palma F, Paula M, Fatela A, Sobral D, Pereira P, Grilo I, Ambrosio P, Torrezão I, Biscaia I, Nunes S, Araújo M, Sâncio S, Valente G, Mendonça S, Verdasca N, Oliveira A, Santos S.OBJECTIVE: Cervical cancer is the third most frequent cancer in women, worldwide and etiologically associated with infection by human papillomavirus (HPV). Following the results of the first epidemiologic population-based CLEOPATRE study in Portugal, it was important to understand the HPV type-specific distribution in women with cervical intraepithelial neoplasia (CIN) grades 2 and 3 and invasive cervical cancer (ICC). METHODS: This was an observational, multicenter, cross-sectional study with retrospective data collection. Between January 2008 and May 2009, paraffin-embedded samples of histologically confirmed cases of CIN2, CIN3, and ICC were collected from the 5 regional health administrations in mainland Portugal. Eligible samples were sent to 2 central laboratories for histological reassessment and HPV genotyping. Prevalence estimates were calculated together with 95% confidence intervals. RESULTS: A total of 582 samples, 177 cases of CIN2, 341 of CIN3, and 64 of ICC, were included. The mean age of participants was 41.8 years (range, 20-88 years). The overall HPV prevalence was 97.9% with a higher prevalence of high-risk genotypes, particularly HPV 16. Multiple infections were observed in 11.2% of the cases. Human papillomavirus prevalence was 95.5% in CIN2, 99.4% in CIN3, and 96.9% in ICC. The 8 more frequent genotypes in order of decreasing frequency were HPV 16, 31, 58, 33, 51, 52, 18, and 35 in CIN2 and HPV 16, 31, 33, 58, 52, 35, 18, and 51 in CIN3. In ICC cases, the 12 detected HPV genotypes were HPV 16, 18, 31, 33, 45, 51, 52, 53, 56, 58, 59, and 73. However, HPV 53 and 73 were always associated to other high-risk genotypes. Human papillomavirus types 31, 51, 52, 56, and 59 were detected in 1 case each. CONCLUSIONS: Human papillomavirus prevalence and patterns of type-specific HPV positivity were comparable with other studies. Current HPV vaccines should protect against HPV genotypes responsible for 77.4% of ICC in Portugal.Lippincott Williams & WilkinsRepositório Científico do Instituto Nacional de SaúdePista, Angelade Oliveira, Carlos F.Lopes, CarlosCunha, Maria JoãoCLEOPATRE Portugal Study Groupa2014-03-18T12:03:17Z2013-032013-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/2163engInt J Gynecol Cancer. 2013 Mar;23(3):500-6. doi: 10.1097/IGC.0b013e318280f26e1048-891Xdoi:10.1097/IGC.0b013e318280f26einfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:08Zoai:repositorio.insa.pt:10400.18/2163Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:13.200784Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
title Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
spellingShingle Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
Pista, Angela
Cancer
Epidemiology
Cervical Intraepithelial Neoplasia
HPV
Portugal
Cleopatre
Infecções Sexualmente Transmissíveis
title_short Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
title_full Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
title_fullStr Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
title_full_unstemmed Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
title_sort Human papillomavirus type distribution in cervical intraepithelial neoplasia grade 2/3 and cervical cancer in Portugal: a CLEOPATRE II Study
author Pista, Angela
author_facet Pista, Angela
de Oliveira, Carlos F.
Lopes, Carlos
Cunha, Maria João
CLEOPATRE Portugal Study Groupa
author_role author
author2 de Oliveira, Carlos F.
Lopes, Carlos
Cunha, Maria João
CLEOPATRE Portugal Study Groupa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Pista, Angela
de Oliveira, Carlos F.
Lopes, Carlos
Cunha, Maria João
CLEOPATRE Portugal Study Groupa
dc.subject.por.fl_str_mv Cancer
Epidemiology
Cervical Intraepithelial Neoplasia
HPV
Portugal
Cleopatre
Infecções Sexualmente Transmissíveis
topic Cancer
Epidemiology
Cervical Intraepithelial Neoplasia
HPV
Portugal
Cleopatre
Infecções Sexualmente Transmissíveis
description Collaborators (54): Tavares A, Dias M, Rocha E, Telhado Mda C, Afonso A, Loureiro M, Horgan C, Marques I, Cortes E, Alegra S, Serra Mdo C, Lima J, Afonso E, Ladeíra AP, Gonçalves L, Sobral N, Reforço AS, Pacheco MA, Enriquez JL, Lagoa A, Ribeiro V, Ferreira L, Cadilla AJ, Furtado JM, Rodrigues J, de Castro PV, e Silva AA, Mota F, Moura P, da Silva TS, Jardim O, Nascimento M, Dacosta A, Borrego J, Fernandes R, Vitorino A, Paula T, Palma F, Paula M, Fatela A, Sobral D, Pereira P, Grilo I, Ambrosio P, Torrezão I, Biscaia I, Nunes S, Araújo M, Sâncio S, Valente G, Mendonça S, Verdasca N, Oliveira A, Santos S.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
2013-03-01T00:00:00Z
2014-03-18T12:03:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/2163
url http://hdl.handle.net/10400.18/2163
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Gynecol Cancer. 2013 Mar;23(3):500-6. doi: 10.1097/IGC.0b013e318280f26e
1048-891X
doi:10.1097/IGC.0b013e318280f26e
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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