Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population

Detalhes bibliográficos
Autor(a) principal: Lemos, Manuel C.
Data de Publicação: 2008
Outros Autores: Fagulha, Ana, Coutinho, Eduarda, Gomes, Leonor, Bastos, Margarida, Barros, Luisa, Carrilho, Francisco, Geraldes, Elizabete, Regateiro, Fernando J., Carvalheiro, Manuela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/4692
Resumo: The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. The distribution of VDR genotype, allele, and haplotype frequencies did not differ significantly between patients and controls. These data suggest that the single nucleotide polymorphisms of the VDR gene are unlikely to contribute significantly to type 1 diabetes susceptibility in the Portuguese population.
id RCAP_9ab8728cfe3a4be6a2abc39a973e112d
oai_identifier_str oai:estudogeral.uc.pt:10316/4692
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str
spelling Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese populationVitamin D receptorSingle nucleotide polymorphismType 1 diabetes mellitusGenetic susceptibilityThe vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. The distribution of VDR genotype, allele, and haplotype frequencies did not differ significantly between patients and controls. These data suggest that the single nucleotide polymorphisms of the VDR gene are unlikely to contribute significantly to type 1 diabetes susceptibility in the Portuguese population.http://www.sciencedirect.com/science/article/B6T3B-4RWHFB8-1/1/512beef9bf7f7bc4d7adebf4d87e5b7a2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/4692http://hdl.handle.net/10316/4692engHuman Immunology. 69:2 (2008) 134-138Lemos, Manuel C.Fagulha, AnaCoutinho, EduardaGomes, LeonorBastos, MargaridaBarros, LuisaCarrilho, FranciscoGeraldes, ElizabeteRegateiro, Fernando J.Carvalheiro, Manuelainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-29T10:05:07ZPortal AgregadorONG
dc.title.none.fl_str_mv Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
title Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
spellingShingle Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
Lemos, Manuel C.
Vitamin D receptor
Single nucleotide polymorphism
Type 1 diabetes mellitus
Genetic susceptibility
title_short Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
title_full Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
title_fullStr Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
title_full_unstemmed Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
title_sort Lack of association of vitamin D receptor gene polymorphisms with susceptibility to type 1 diabetes mellitus in the Portuguese population
author Lemos, Manuel C.
author_facet Lemos, Manuel C.
Fagulha, Ana
Coutinho, Eduarda
Gomes, Leonor
Bastos, Margarida
Barros, Luisa
Carrilho, Francisco
Geraldes, Elizabete
Regateiro, Fernando J.
Carvalheiro, Manuela
author_role author
author2 Fagulha, Ana
Coutinho, Eduarda
Gomes, Leonor
Bastos, Margarida
Barros, Luisa
Carrilho, Francisco
Geraldes, Elizabete
Regateiro, Fernando J.
Carvalheiro, Manuela
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lemos, Manuel C.
Fagulha, Ana
Coutinho, Eduarda
Gomes, Leonor
Bastos, Margarida
Barros, Luisa
Carrilho, Francisco
Geraldes, Elizabete
Regateiro, Fernando J.
Carvalheiro, Manuela
dc.subject.por.fl_str_mv Vitamin D receptor
Single nucleotide polymorphism
Type 1 diabetes mellitus
Genetic susceptibility
topic Vitamin D receptor
Single nucleotide polymorphism
Type 1 diabetes mellitus
Genetic susceptibility
description The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207 patients with type 1 diabetes and 249 controls for the FokI T>C (rs10735810), BsmI A>G (rs1544410), ApaI G>T (rs7975232), and TaqI C>T (rs731236) single nucleotide polymorphisms by polymerase chain reaction and restriction fragment length polymorphism analysis. The distribution of VDR genotype, allele, and haplotype frequencies did not differ significantly between patients and controls. These data suggest that the single nucleotide polymorphisms of the VDR gene are unlikely to contribute significantly to type 1 diabetes susceptibility in the Portuguese population.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/4692
http://hdl.handle.net/10316/4692
url http://hdl.handle.net/10316/4692
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Human Immunology. 69:2 (2008) 134-138
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1777302588185640960

Registros relacionados