Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?

Detalhes bibliográficos
Autor(a) principal: Monteiro, P
Data de Publicação: 2003
Outros Autores: Oliveira, PJ, Gonçalves, L
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/926
Resumo: Recent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations. This has clearly highlighted the important role played by cardiac mitochondria in these events. At first only associated with energy production, mitochondria have been clearly shown to have other important functions, like the maintenance of calcium homeostasis, as well as ischemic and non-ischemic preconditioning, and also modulation of cellular life and death. The aims of this review are twofold: firstly, to review the current knowledge on mitochondrial morphology and structure, and how these can be affected by ischemia and ischemia-reperfusion; and secondly, to summarize the role of cardiac mitochondria in cardioprotection and modulation of cell death mechanisms.
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spelling Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?Mitochondria: role in ischemia, reperfusion and cell deathMitocôndrias CardiacasIsquemia do MiocárdioReperfusão MiocárdicaRecent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations. This has clearly highlighted the important role played by cardiac mitochondria in these events. At first only associated with energy production, mitochondria have been clearly shown to have other important functions, like the maintenance of calcium homeostasis, as well as ischemic and non-ischemic preconditioning, and also modulation of cellular life and death. The aims of this review are twofold: firstly, to review the current knowledge on mitochondrial morphology and structure, and how these can be affected by ischemia and ischemia-reperfusion; and secondly, to summarize the role of cardiac mitochondria in cardioprotection and modulation of cell death mechanisms.Sociedade Portuguesa de CardiologiaRIHUCMonteiro, POliveira, PJGonçalves, L2010-12-22T16:25:11Z20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/926porRev Port Cardiol. 2003 Feb;22(2):233-54.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:22:07Zoai:rihuc.huc.min-saude.pt:10400.4/926Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:27.725271Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
Mitochondria: role in ischemia, reperfusion and cell death
title Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
spellingShingle Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
Monteiro, P
Mitocôndrias Cardiacas
Isquemia do Miocárdio
Reperfusão Miocárdica
title_short Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
title_full Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
title_fullStr Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
title_full_unstemmed Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
title_sort Mitocôndria: que papel na isquémia, reperfusão e morte cerebral?
author Monteiro, P
author_facet Monteiro, P
Oliveira, PJ
Gonçalves, L
author_role author
author2 Oliveira, PJ
Gonçalves, L
author2_role author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Monteiro, P
Oliveira, PJ
Gonçalves, L
dc.subject.por.fl_str_mv Mitocôndrias Cardiacas
Isquemia do Miocárdio
Reperfusão Miocárdica
topic Mitocôndrias Cardiacas
Isquemia do Miocárdio
Reperfusão Miocárdica
description Recent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations. This has clearly highlighted the important role played by cardiac mitochondria in these events. At first only associated with energy production, mitochondria have been clearly shown to have other important functions, like the maintenance of calcium homeostasis, as well as ischemic and non-ischemic preconditioning, and also modulation of cellular life and death. The aims of this review are twofold: firstly, to review the current knowledge on mitochondrial morphology and structure, and how these can be affected by ischemia and ischemia-reperfusion; and secondly, to summarize the role of cardiac mitochondria in cardioprotection and modulation of cell death mechanisms.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
2010-12-22T16:25:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/926
url http://hdl.handle.net/10400.4/926
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Rev Port Cardiol. 2003 Feb;22(2):233-54.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Cardiologia
publisher.none.fl_str_mv Sociedade Portuguesa de Cardiologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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