Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease

Detalhes bibliográficos
Autor(a) principal: Carvalho, Fábia Susana Ginja de
Data de Publicação: 2017
Outros Autores: Medeiros, Inês Ambrosio de, Antunes, Henedina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/48479
Resumo: OBJECTIVES: Iron deficiency is the most common cause of anemia in children with inflammatory bowel disease, although the real prevalence is unknown. Intravenous iron is suggested as the first line treatment. This study aims to determine the prevalence of iron deficiency anemia in children with inflammatory bowel disease followed in a Pediatric Gastroenterology Unit of a tertiary center and to evaluate this unit's experience with intravenous iron. MATERIALS AND METHODS: A retrospective cohort study was designed involving children with inflammatory bowel disease followed in that unit between January 2001 and April 2016. Laboratory results were collected at the moment of diagnosis, after one-year follow-up and prior each IV iron administration performed during the study period. Anemia was defined according to World Health Organization criteria and the iron deficiency was defined using recent guidelines. RESULTS: Were studied 69 patients 71% had CD and 29% UC. 50.7% were female. Mean patient age at diagnosis was 13.3 years (range 1--17 years). Prevalence of ID and IDA at diagnosis was 76.8% and 43.5%, respectively. After one year follow-up, those values decreased to 68.1% (p=.182) and 21.7% (p=.002), respectively. Hemoglobin significantly increased (p<.001). Intravenous iron was administered to 92.8% of patients. No adverse reactions were reported. CONCLUSIONS: Intravenous iron is the first line in the treatment of Iron deficiency anemia in Inflammatory Bowel disease and it is safe and effective. Persistent anemia and iron deficiency are common.
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spelling Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel diseaseIron deficiencyIron deficiency anemiaIntravenous ironInflammatory bowel diseasePediatricsScience & TechnologyOBJECTIVES: Iron deficiency is the most common cause of anemia in children with inflammatory bowel disease, although the real prevalence is unknown. Intravenous iron is suggested as the first line treatment. This study aims to determine the prevalence of iron deficiency anemia in children with inflammatory bowel disease followed in a Pediatric Gastroenterology Unit of a tertiary center and to evaluate this unit's experience with intravenous iron. MATERIALS AND METHODS: A retrospective cohort study was designed involving children with inflammatory bowel disease followed in that unit between January 2001 and April 2016. Laboratory results were collected at the moment of diagnosis, after one-year follow-up and prior each IV iron administration performed during the study period. Anemia was defined according to World Health Organization criteria and the iron deficiency was defined using recent guidelines. RESULTS: Were studied 69 patients 71% had CD and 29% UC. 50.7% were female. Mean patient age at diagnosis was 13.3 years (range 1--17 years). Prevalence of ID and IDA at diagnosis was 76.8% and 43.5%, respectively. After one year follow-up, those values decreased to 68.1% (p=.182) and 21.7% (p=.002), respectively. Hemoglobin significantly increased (p<.001). Intravenous iron was administered to 92.8% of patients. No adverse reactions were reported. CONCLUSIONS: Intravenous iron is the first line in the treatment of Iron deficiency anemia in Inflammatory Bowel disease and it is safe and effective. Persistent anemia and iron deficiency are common.info:eu-repo/semantics/publishedVersionTaylor & FrancisUniversidade do MinhoCarvalho, Fábia Susana Ginja deMedeiros, Inês Ambrosio deAntunes, Henedina2017-062017-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/48479engFábia Susana Ginja de Carvalho, Inês Ambrósio de Medeiros & Henedina Antunes (2017): Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease, Scandinavian Journal of Gastroenterology, DOI: 10.1080/00365521.2017.13421370036-552110.1080/00365521.2017.134213728643539http://www.tandfonline.com/doi/full/10.1080/00365521.2017.1342137info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:15Zoai:repositorium.sdum.uminho.pt:1822/48479Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:45:20.845951Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
title Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
spellingShingle Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
Carvalho, Fábia Susana Ginja de
Iron deficiency
Iron deficiency anemia
Intravenous iron
Inflammatory bowel disease
Pediatrics
Science & Technology
title_short Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
title_full Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
title_fullStr Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
title_full_unstemmed Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
title_sort Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease
author Carvalho, Fábia Susana Ginja de
author_facet Carvalho, Fábia Susana Ginja de
Medeiros, Inês Ambrosio de
Antunes, Henedina
author_role author
author2 Medeiros, Inês Ambrosio de
Antunes, Henedina
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Carvalho, Fábia Susana Ginja de
Medeiros, Inês Ambrosio de
Antunes, Henedina
dc.subject.por.fl_str_mv Iron deficiency
Iron deficiency anemia
Intravenous iron
Inflammatory bowel disease
Pediatrics
Science & Technology
topic Iron deficiency
Iron deficiency anemia
Intravenous iron
Inflammatory bowel disease
Pediatrics
Science & Technology
description OBJECTIVES: Iron deficiency is the most common cause of anemia in children with inflammatory bowel disease, although the real prevalence is unknown. Intravenous iron is suggested as the first line treatment. This study aims to determine the prevalence of iron deficiency anemia in children with inflammatory bowel disease followed in a Pediatric Gastroenterology Unit of a tertiary center and to evaluate this unit's experience with intravenous iron. MATERIALS AND METHODS: A retrospective cohort study was designed involving children with inflammatory bowel disease followed in that unit between January 2001 and April 2016. Laboratory results were collected at the moment of diagnosis, after one-year follow-up and prior each IV iron administration performed during the study period. Anemia was defined according to World Health Organization criteria and the iron deficiency was defined using recent guidelines. RESULTS: Were studied 69 patients 71% had CD and 29% UC. 50.7% were female. Mean patient age at diagnosis was 13.3 years (range 1--17 years). Prevalence of ID and IDA at diagnosis was 76.8% and 43.5%, respectively. After one year follow-up, those values decreased to 68.1% (p=.182) and 21.7% (p=.002), respectively. Hemoglobin significantly increased (p<.001). Intravenous iron was administered to 92.8% of patients. No adverse reactions were reported. CONCLUSIONS: Intravenous iron is the first line in the treatment of Iron deficiency anemia in Inflammatory Bowel disease and it is safe and effective. Persistent anemia and iron deficiency are common.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
2017-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/48479
url http://hdl.handle.net/1822/48479
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fábia Susana Ginja de Carvalho, Inês Ambrósio de Medeiros & Henedina Antunes (2017): Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with inflammatory bowel disease, Scandinavian Journal of Gastroenterology, DOI: 10.1080/00365521.2017.1342137
0036-5521
10.1080/00365521.2017.1342137
28643539
http://www.tandfonline.com/doi/full/10.1080/00365521.2017.1342137
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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