Maritime halophyte species from southern Portugal as sources of bioactive molecules
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11094 |
Resumo: | Extracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC50 = 0.1 mg/mL) and J. acutus (IC50 = 0.4 mg/mL), and the ether extracts of J. acutus (IC50 = 0.2 mg/mL) and A. macrostachyum (IC50 = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC50 = 0.4 mg/mL) and H. portulacoides (IC50 = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC50 = 109 mu g/mL) and the hexane extract of P. coronopus (IC50 = 98.0 mu g/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells. |
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Maritime halophyte species from southern Portugal as sources of bioactive moleculesEdulis methanol extractAntioxidant activityJuncus-AcutusArthrocnemum-MacrostachyumAntimicrobial activitiesStaphylococcus-AureusPlantsStressGrowthCellsExtracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC50 = 0.1 mg/mL) and J. acutus (IC50 = 0.4 mg/mL), and the ether extracts of J. acutus (IC50 = 0.2 mg/mL) and A. macrostachyum (IC50 = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC50 = 0.4 mg/mL) and H. portulacoides (IC50 = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC50 = 109 mu g/mL) and the hexane extract of P. coronopus (IC50 = 98.0 mu g/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells.SEABIOMED project [PTDC/MAR/103957/2008]; XtremeBio project - Foundation for Science and Technology (FCT); Portuguese National Budget; Danish Research Council for Independent Research, Nature and Universe [10-085264]MDPISapientiaRodrigues, Maria JoaoGangadhar, Katkam N.Vizetto-Duarte, CWubshet, Sileshi G.Nyberg, Nils T.Barreira, LuísaJ. C. or Varela J. or Varela J.C.S., VarelaCustodio, Luisa2018-12-07T14:52:30Z2014-042014-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11094eng1660-339710.3390/md12042228info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:22:50Zoai:sapientia.ualg.pt:10400.1/11094Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:37.370490Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
title |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
spellingShingle |
Maritime halophyte species from southern Portugal as sources of bioactive molecules Rodrigues, Maria Joao Edulis methanol extract Antioxidant activity Juncus-Acutus Arthrocnemum-Macrostachyum Antimicrobial activities Staphylococcus-Aureus Plants Stress Growth Cells |
title_short |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
title_full |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
title_fullStr |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
title_full_unstemmed |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
title_sort |
Maritime halophyte species from southern Portugal as sources of bioactive molecules |
author |
Rodrigues, Maria Joao |
author_facet |
Rodrigues, Maria Joao Gangadhar, Katkam N. Vizetto-Duarte, C Wubshet, Sileshi G. Nyberg, Nils T. Barreira, Luísa J. C. or Varela J. or Varela J.C.S., Varela Custodio, Luisa |
author_role |
author |
author2 |
Gangadhar, Katkam N. Vizetto-Duarte, C Wubshet, Sileshi G. Nyberg, Nils T. Barreira, Luísa J. C. or Varela J. or Varela J.C.S., Varela Custodio, Luisa |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Rodrigues, Maria Joao Gangadhar, Katkam N. Vizetto-Duarte, C Wubshet, Sileshi G. Nyberg, Nils T. Barreira, Luísa J. C. or Varela J. or Varela J.C.S., Varela Custodio, Luisa |
dc.subject.por.fl_str_mv |
Edulis methanol extract Antioxidant activity Juncus-Acutus Arthrocnemum-Macrostachyum Antimicrobial activities Staphylococcus-Aureus Plants Stress Growth Cells |
topic |
Edulis methanol extract Antioxidant activity Juncus-Acutus Arthrocnemum-Macrostachyum Antimicrobial activities Staphylococcus-Aureus Plants Stress Growth Cells |
description |
Extracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC50 = 0.1 mg/mL) and J. acutus (IC50 = 0.4 mg/mL), and the ether extracts of J. acutus (IC50 = 0.2 mg/mL) and A. macrostachyum (IC50 = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC50 = 0.4 mg/mL) and H. portulacoides (IC50 = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC50 = 109 mu g/mL) and the hexane extract of P. coronopus (IC50 = 98.0 mu g/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04 2014-04-01T00:00:00Z 2018-12-07T14:52:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11094 |
url |
http://hdl.handle.net/10400.1/11094 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1660-3397 10.3390/md12042228 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133260792463360 |