Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination

Detalhes bibliográficos
Autor(a) principal: Scutelnic, Adrian
Data de Publicação: 2022
Outros Autores: Krzywicka, Katarzyna, Mbroh, Joshua, van de Munckhof, Anita, van Kammen, Mayte Sánchez, de Sousa, Diana Aguiar, Lindgren, Erik, Jood, Katarina, Günther, Albrecht, Hiltunen, Sini, Putaala, Jukka, Tiede, Andreas, Maier, Frank, Kern, Rolf, Bartsch, Thorsten, Althaus, Katharina, Ciccone, Alfonso, Wiedmann, Markus, Skjelland, Mona, Medina, Antonio, Cuadrado‐Godia, Elisa, Cox, Thomas, Aujayeb, Avinash, Raposo, Nicolas, Garambois, Katia, Payen, Jean‐Francois, Vuillier, Fabrice, Franchineau, Guillaume, Timsit, Serge, Bougon, David, Dubois, Marie‐Cécile, Tawa, Audrey, Tracol, Clement, De Maistre, Emmanuel, Bonneville, Fabrice, Vayne, Caroline, Mengel, Annerose, Michalski, Dominik, Pelz, Johann, Wittstock, Matthias, Bode, Felix, Zimmermann, Julian, Schouten, Judith, Buture, Alina, Murphy, Sean, Palma, Vincenzo, Negro, Alberto, Gutschalk, Alexander, Nagel, Simon, Schoenenberger, Silvia, Frisullo, Giovanni, Zanferrari, Carla, Grillo, Francesco, Giammello, Fabrizio, Martin, Mar Morin, Cervera, Alvaro, Burrow, Jim, Esperon, Carlos Garcia, Chew, Beng Lim Alvin, Kleinig, Timothy J., Soriano, Cristina, Zimatore, Domenico S., Petruzzellis, Marco, Elkady, Ahmed, Miranda, Miguel S., Fernandes, João, Vogel, Åslög Hellström, Johansson, Elias, Philip, Anemon Puthuppallil, Coutts, Shelagh B., Bal, Simerpreet, Buck, Brian, Legault, Catherine, Blacquiere, Dylan, Katzberg, Hans D., Field, Thalia S., Dizonno, Vanessa, Gattringer, Thomas, Jacobi, Christian, Devroye, Annemie, Lemmens, Robin, Kristoffersen, Espen Saxhaug, di Poggio, Monica Bandettini, Ghiasian, Masoud, Karapanayiotides, Theodoros, Chatterton, Sophie, Wronski, Miriam, Ng, Karl, Kahnis, Robert, Geeraerts, Thomas, Reiner, Peggy, Cordonnier, Charlotte, Middeldorp, Saskia, Levi, Marcel, van Gorp, Eric C. M., van de Beek, Diederik, Brodard, Justine, Kremer Hovinga, Johanna A., Kruip, Marieke J. H. A., Tatlisumak, Turgut, Ferro, José, Coutinho, Jonathan M., Arnold, Marcel, Poli, Sven, Heldner, Mirjam R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/54540
Resumo: © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.562 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
id RCAP_9ca2f72ed9c4e319e41f5e68a04868ce
oai_identifier_str oai:repositorio.ul.pt:10451/54540
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.562 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Objective: Cerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus-based severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality. Methods: We used data from an international prospective registry of patients with CVT after the adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable, or definite VITT-CVT cases included until January 18, 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis. Results: Ninety-nine patients with VITT-CVT from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11 of 24 (46%), and 28 of 37 (76%) of the patients diagnosed in March, April, and from May onward, respectively, were treated in-line with VITT recommendations (p < 0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 [32%] vs 29/55 [52%], adjusted odds ratio [OR] = 0.43, 95% confidence interval [CI] = 0.16-1.19). However, patients who received immunomodulation had lower mortality (19/65 [29%] vs 24/34 [70%], adjusted OR = 0.19, 95% CI = 0.06-0.58). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 [33%] vs 13/35 [37%], adjusted OR = 0.70, 95% CI = 0.24-2.04). Mortality was also not significantly influenced by platelet transfusion (17/27 [63%] vs 26/72 [36%], adjusted OR = 2.19, 95% CI = 0.74-6.54). Conclusions: In patients with VITT-CVT, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. ANN NEUROL 2022;92:562-573.This research was funded by The Netherlands Organisation for Health Research and Development (ZonMw, grant number 10430072110005) and the Dr. C. J. Vaillant Foundation.WileyRepositório da Universidade de LisboaScutelnic, AdrianKrzywicka, KatarzynaMbroh, Joshuavan de Munckhof, Anitavan Kammen, Mayte Sánchezde Sousa, Diana AguiarLindgren, ErikJood, KatarinaGünther, AlbrechtHiltunen, SiniPutaala, JukkaTiede, AndreasMaier, FrankKern, RolfBartsch, ThorstenAlthaus, KatharinaCiccone, AlfonsoWiedmann, MarkusSkjelland, MonaMedina, AntonioCuadrado‐Godia, ElisaCox, ThomasAujayeb, AvinashRaposo, NicolasGarambois, KatiaPayen, Jean‐FrancoisVuillier, FabriceFranchineau, GuillaumeTimsit, SergeBougon, DavidDubois, Marie‐CécileTawa, AudreyTracol, ClementDe Maistre, EmmanuelBonneville, FabriceVayne, CarolineMengel, AnneroseMichalski, DominikPelz, JohannWittstock, MatthiasBode, FelixZimmermann, JulianSchouten, JudithButure, AlinaMurphy, SeanPalma, VincenzoNegro, AlbertoGutschalk, AlexanderNagel, SimonSchoenenberger, SilviaFrisullo, GiovanniZanferrari, CarlaGrillo, FrancescoGiammello, FabrizioMartin, Mar MorinCervera, AlvaroBurrow, JimEsperon, Carlos GarciaChew, Beng Lim AlvinKleinig, Timothy J.Soriano, CristinaZimatore, Domenico S.Petruzzellis, MarcoElkady, AhmedMiranda, Miguel S.Fernandes, JoãoVogel, Åslög HellströmJohansson, EliasPhilip, Anemon PuthuppallilCoutts, Shelagh B.Bal, SimerpreetBuck, BrianLegault, CatherineBlacquiere, DylanKatzberg, Hans D.Field, Thalia S.Dizonno, VanessaGattringer, ThomasJacobi, ChristianDevroye, AnnemieLemmens, RobinKristoffersen, Espen Saxhaugdi Poggio, Monica BandettiniGhiasian, MasoudKarapanayiotides, TheodorosChatterton, SophieWronski, MiriamNg, KarlKahnis, RobertGeeraerts, ThomasReiner, PeggyCordonnier, CharlotteMiddeldorp, SaskiaLevi, Marcelvan Gorp, Eric C. M.van de Beek, DiederikBrodard, JustineKremer Hovinga, Johanna A.Kruip, Marieke J. H. A.Tatlisumak, TurgutFerro, JoséCoutinho, Jonathan M.Arnold, MarcelPoli, SvenHeldner, Mirjam R.2022-09-21T14:36:07Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54540engAnn Neurol. 2022 Oct;92(4):562-5730364-513410.1002/ana.264311531-8249info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:00:57Zoai:repositorio.ul.pt:10451/54540Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:20.829681Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
title Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
spellingShingle Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
Scutelnic, Adrian
title_short Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
title_full Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
title_fullStr Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
title_full_unstemmed Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
title_sort Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
author Scutelnic, Adrian
author_facet Scutelnic, Adrian
Krzywicka, Katarzyna
Mbroh, Joshua
van de Munckhof, Anita
van Kammen, Mayte Sánchez
de Sousa, Diana Aguiar
Lindgren, Erik
Jood, Katarina
Günther, Albrecht
Hiltunen, Sini
Putaala, Jukka
Tiede, Andreas
Maier, Frank
Kern, Rolf
Bartsch, Thorsten
Althaus, Katharina
Ciccone, Alfonso
Wiedmann, Markus
Skjelland, Mona
Medina, Antonio
Cuadrado‐Godia, Elisa
Cox, Thomas
Aujayeb, Avinash
Raposo, Nicolas
Garambois, Katia
Payen, Jean‐Francois
Vuillier, Fabrice
Franchineau, Guillaume
Timsit, Serge
Bougon, David
Dubois, Marie‐Cécile
Tawa, Audrey
Tracol, Clement
De Maistre, Emmanuel
Bonneville, Fabrice
Vayne, Caroline
Mengel, Annerose
Michalski, Dominik
Pelz, Johann
Wittstock, Matthias
Bode, Felix
Zimmermann, Julian
Schouten, Judith
Buture, Alina
Murphy, Sean
Palma, Vincenzo
Negro, Alberto
Gutschalk, Alexander
Nagel, Simon
Schoenenberger, Silvia
Frisullo, Giovanni
Zanferrari, Carla
Grillo, Francesco
Giammello, Fabrizio
Martin, Mar Morin
Cervera, Alvaro
Burrow, Jim
Esperon, Carlos Garcia
Chew, Beng Lim Alvin
Kleinig, Timothy J.
Soriano, Cristina
Zimatore, Domenico S.
Petruzzellis, Marco
Elkady, Ahmed
Miranda, Miguel S.
Fernandes, João
Vogel, Åslög Hellström
Johansson, Elias
Philip, Anemon Puthuppallil
Coutts, Shelagh B.
Bal, Simerpreet
Buck, Brian
Legault, Catherine
Blacquiere, Dylan
Katzberg, Hans D.
Field, Thalia S.
Dizonno, Vanessa
Gattringer, Thomas
Jacobi, Christian
Devroye, Annemie
Lemmens, Robin
Kristoffersen, Espen Saxhaug
di Poggio, Monica Bandettini
Ghiasian, Masoud
Karapanayiotides, Theodoros
Chatterton, Sophie
Wronski, Miriam
Ng, Karl
Kahnis, Robert
Geeraerts, Thomas
Reiner, Peggy
Cordonnier, Charlotte
Middeldorp, Saskia
Levi, Marcel
van Gorp, Eric C. M.
van de Beek, Diederik
Brodard, Justine
Kremer Hovinga, Johanna A.
Kruip, Marieke J. H. A.
Tatlisumak, Turgut
Ferro, José
Coutinho, Jonathan M.
Arnold, Marcel
Poli, Sven
Heldner, Mirjam R.
author_role author
author2 Krzywicka, Katarzyna
Mbroh, Joshua
van de Munckhof, Anita
van Kammen, Mayte Sánchez
de Sousa, Diana Aguiar
Lindgren, Erik
Jood, Katarina
Günther, Albrecht
Hiltunen, Sini
Putaala, Jukka
Tiede, Andreas
Maier, Frank
Kern, Rolf
Bartsch, Thorsten
Althaus, Katharina
Ciccone, Alfonso
Wiedmann, Markus
Skjelland, Mona
Medina, Antonio
Cuadrado‐Godia, Elisa
Cox, Thomas
Aujayeb, Avinash
Raposo, Nicolas
Garambois, Katia
Payen, Jean‐Francois
Vuillier, Fabrice
Franchineau, Guillaume
Timsit, Serge
Bougon, David
Dubois, Marie‐Cécile
Tawa, Audrey
Tracol, Clement
De Maistre, Emmanuel
Bonneville, Fabrice
Vayne, Caroline
Mengel, Annerose
Michalski, Dominik
Pelz, Johann
Wittstock, Matthias
Bode, Felix
Zimmermann, Julian
Schouten, Judith
Buture, Alina
Murphy, Sean
Palma, Vincenzo
Negro, Alberto
Gutschalk, Alexander
Nagel, Simon
Schoenenberger, Silvia
Frisullo, Giovanni
Zanferrari, Carla
Grillo, Francesco
Giammello, Fabrizio
Martin, Mar Morin
Cervera, Alvaro
Burrow, Jim
Esperon, Carlos Garcia
Chew, Beng Lim Alvin
Kleinig, Timothy J.
Soriano, Cristina
Zimatore, Domenico S.
Petruzzellis, Marco
Elkady, Ahmed
Miranda, Miguel S.
Fernandes, João
Vogel, Åslög Hellström
Johansson, Elias
Philip, Anemon Puthuppallil
Coutts, Shelagh B.
Bal, Simerpreet
Buck, Brian
Legault, Catherine
Blacquiere, Dylan
Katzberg, Hans D.
Field, Thalia S.
Dizonno, Vanessa
Gattringer, Thomas
Jacobi, Christian
Devroye, Annemie
Lemmens, Robin
Kristoffersen, Espen Saxhaug
di Poggio, Monica Bandettini
Ghiasian, Masoud
Karapanayiotides, Theodoros
Chatterton, Sophie
Wronski, Miriam
Ng, Karl
Kahnis, Robert
Geeraerts, Thomas
Reiner, Peggy
Cordonnier, Charlotte
Middeldorp, Saskia
Levi, Marcel
van Gorp, Eric C. M.
van de Beek, Diederik
Brodard, Justine
Kremer Hovinga, Johanna A.
Kruip, Marieke J. H. A.
Tatlisumak, Turgut
Ferro, José
Coutinho, Jonathan M.
Arnold, Marcel
Poli, Sven
Heldner, Mirjam R.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Scutelnic, Adrian
Krzywicka, Katarzyna
Mbroh, Joshua
van de Munckhof, Anita
van Kammen, Mayte Sánchez
de Sousa, Diana Aguiar
Lindgren, Erik
Jood, Katarina
Günther, Albrecht
Hiltunen, Sini
Putaala, Jukka
Tiede, Andreas
Maier, Frank
Kern, Rolf
Bartsch, Thorsten
Althaus, Katharina
Ciccone, Alfonso
Wiedmann, Markus
Skjelland, Mona
Medina, Antonio
Cuadrado‐Godia, Elisa
Cox, Thomas
Aujayeb, Avinash
Raposo, Nicolas
Garambois, Katia
Payen, Jean‐Francois
Vuillier, Fabrice
Franchineau, Guillaume
Timsit, Serge
Bougon, David
Dubois, Marie‐Cécile
Tawa, Audrey
Tracol, Clement
De Maistre, Emmanuel
Bonneville, Fabrice
Vayne, Caroline
Mengel, Annerose
Michalski, Dominik
Pelz, Johann
Wittstock, Matthias
Bode, Felix
Zimmermann, Julian
Schouten, Judith
Buture, Alina
Murphy, Sean
Palma, Vincenzo
Negro, Alberto
Gutschalk, Alexander
Nagel, Simon
Schoenenberger, Silvia
Frisullo, Giovanni
Zanferrari, Carla
Grillo, Francesco
Giammello, Fabrizio
Martin, Mar Morin
Cervera, Alvaro
Burrow, Jim
Esperon, Carlos Garcia
Chew, Beng Lim Alvin
Kleinig, Timothy J.
Soriano, Cristina
Zimatore, Domenico S.
Petruzzellis, Marco
Elkady, Ahmed
Miranda, Miguel S.
Fernandes, João
Vogel, Åslög Hellström
Johansson, Elias
Philip, Anemon Puthuppallil
Coutts, Shelagh B.
Bal, Simerpreet
Buck, Brian
Legault, Catherine
Blacquiere, Dylan
Katzberg, Hans D.
Field, Thalia S.
Dizonno, Vanessa
Gattringer, Thomas
Jacobi, Christian
Devroye, Annemie
Lemmens, Robin
Kristoffersen, Espen Saxhaug
di Poggio, Monica Bandettini
Ghiasian, Masoud
Karapanayiotides, Theodoros
Chatterton, Sophie
Wronski, Miriam
Ng, Karl
Kahnis, Robert
Geeraerts, Thomas
Reiner, Peggy
Cordonnier, Charlotte
Middeldorp, Saskia
Levi, Marcel
van Gorp, Eric C. M.
van de Beek, Diederik
Brodard, Justine
Kremer Hovinga, Johanna A.
Kruip, Marieke J. H. A.
Tatlisumak, Turgut
Ferro, José
Coutinho, Jonathan M.
Arnold, Marcel
Poli, Sven
Heldner, Mirjam R.
description © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.562 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-21T14:36:07Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/54540
url http://hdl.handle.net/10451/54540
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ann Neurol. 2022 Oct;92(4):562-573
0364-5134
10.1002/ana.26431
1531-8249
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134605234667520