Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/54540 |
Resumo: | © 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.562 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.562 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Objective: Cerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus-based severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccines. In March 2021, after autoimmune pathogenesis of VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non-heparin anticoagulants, and avoidance of platelet transfusion. The aim of this study was to evaluate adherence to these recommendations and its association with mortality. Methods: We used data from an international prospective registry of patients with CVT after the adenovirus-based SARS-CoV-2 vaccination. We analyzed possible, probable, or definite VITT-CVT cases included until January 18, 2022. Immunomodulation entailed administration of intravenous immunoglobulins and/or plasmapheresis. Results: Ninety-nine patients with VITT-CVT from 71 hospitals in 17 countries were analyzed. Five of 38 (13%), 11 of 24 (46%), and 28 of 37 (76%) of the patients diagnosed in March, April, and from May onward, respectively, were treated in-line with VITT recommendations (p < 0.001). Overall, treatment according to recommendations had no statistically significant influence on mortality (14/44 [32%] vs 29/55 [52%], adjusted odds ratio [OR] = 0.43, 95% confidence interval [CI] = 0.16-1.19). However, patients who received immunomodulation had lower mortality (19/65 [29%] vs 24/34 [70%], adjusted OR = 0.19, 95% CI = 0.06-0.58). Treatment with non-heparin anticoagulants instead of heparins was not associated with lower mortality (17/51 [33%] vs 13/35 [37%], adjusted OR = 0.70, 95% CI = 0.24-2.04). Mortality was also not significantly influenced by platelet transfusion (17/27 [63%] vs 26/72 [36%], adjusted OR = 2.19, 95% CI = 0.74-6.54). Conclusions: In patients with VITT-CVT, adherence to VITT treatment recommendations improved over time. Immunomodulation seems crucial for reducing mortality of VITT-CVT. ANN NEUROL 2022;92:562-573.This research was funded by The Netherlands Organisation for Health Research and Development (ZonMw, grant number 10430072110005) and the Dr. C. J. Vaillant Foundation.WileyRepositório da Universidade de LisboaScutelnic, AdrianKrzywicka, KatarzynaMbroh, Joshuavan de Munckhof, Anitavan Kammen, Mayte Sánchezde Sousa, Diana AguiarLindgren, ErikJood, KatarinaGünther, AlbrechtHiltunen, SiniPutaala, JukkaTiede, AndreasMaier, FrankKern, RolfBartsch, ThorstenAlthaus, KatharinaCiccone, AlfonsoWiedmann, MarkusSkjelland, MonaMedina, AntonioCuadrado‐Godia, ElisaCox, ThomasAujayeb, AvinashRaposo, NicolasGarambois, KatiaPayen, Jean‐FrancoisVuillier, FabriceFranchineau, GuillaumeTimsit, SergeBougon, DavidDubois, Marie‐CécileTawa, AudreyTracol, ClementDe Maistre, EmmanuelBonneville, FabriceVayne, CarolineMengel, AnneroseMichalski, DominikPelz, JohannWittstock, MatthiasBode, FelixZimmermann, JulianSchouten, JudithButure, AlinaMurphy, SeanPalma, VincenzoNegro, AlbertoGutschalk, AlexanderNagel, SimonSchoenenberger, SilviaFrisullo, GiovanniZanferrari, CarlaGrillo, FrancescoGiammello, FabrizioMartin, Mar MorinCervera, AlvaroBurrow, JimEsperon, Carlos GarciaChew, Beng Lim AlvinKleinig, Timothy J.Soriano, CristinaZimatore, Domenico S.Petruzzellis, MarcoElkady, AhmedMiranda, Miguel S.Fernandes, JoãoVogel, Åslög HellströmJohansson, EliasPhilip, Anemon PuthuppallilCoutts, Shelagh B.Bal, SimerpreetBuck, BrianLegault, CatherineBlacquiere, DylanKatzberg, Hans D.Field, Thalia S.Dizonno, VanessaGattringer, ThomasJacobi, ChristianDevroye, AnnemieLemmens, RobinKristoffersen, Espen Saxhaugdi Poggio, Monica BandettiniGhiasian, MasoudKarapanayiotides, TheodorosChatterton, SophieWronski, MiriamNg, KarlKahnis, RobertGeeraerts, ThomasReiner, PeggyCordonnier, CharlotteMiddeldorp, SaskiaLevi, Marcelvan Gorp, Eric C. M.van de Beek, DiederikBrodard, JustineKremer Hovinga, Johanna A.Kruip, Marieke J. H. A.Tatlisumak, TurgutFerro, JoséCoutinho, Jonathan M.Arnold, MarcelPoli, SvenHeldner, Mirjam R.2022-09-21T14:36:07Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54540engAnn Neurol. 2022 Oct;92(4):562-5730364-513410.1002/ana.264311531-8249info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:00:57Zoai:repositorio.ul.pt:10451/54540Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:20.829681Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
title |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
spellingShingle |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination Scutelnic, Adrian |
title_short |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
title_full |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
title_fullStr |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
title_full_unstemmed |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
title_sort |
Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination |
author |
Scutelnic, Adrian |
author_facet |
Scutelnic, Adrian Krzywicka, Katarzyna Mbroh, Joshua van de Munckhof, Anita van Kammen, Mayte Sánchez de Sousa, Diana Aguiar Lindgren, Erik Jood, Katarina Günther, Albrecht Hiltunen, Sini Putaala, Jukka Tiede, Andreas Maier, Frank Kern, Rolf Bartsch, Thorsten Althaus, Katharina Ciccone, Alfonso Wiedmann, Markus Skjelland, Mona Medina, Antonio Cuadrado‐Godia, Elisa Cox, Thomas Aujayeb, Avinash Raposo, Nicolas Garambois, Katia Payen, Jean‐Francois Vuillier, Fabrice Franchineau, Guillaume Timsit, Serge Bougon, David Dubois, Marie‐Cécile Tawa, Audrey Tracol, Clement De Maistre, Emmanuel Bonneville, Fabrice Vayne, Caroline Mengel, Annerose Michalski, Dominik Pelz, Johann Wittstock, Matthias Bode, Felix Zimmermann, Julian Schouten, Judith Buture, Alina Murphy, Sean Palma, Vincenzo Negro, Alberto Gutschalk, Alexander Nagel, Simon Schoenenberger, Silvia Frisullo, Giovanni Zanferrari, Carla Grillo, Francesco Giammello, Fabrizio Martin, Mar Morin Cervera, Alvaro Burrow, Jim Esperon, Carlos Garcia Chew, Beng Lim Alvin Kleinig, Timothy J. Soriano, Cristina Zimatore, Domenico S. Petruzzellis, Marco Elkady, Ahmed Miranda, Miguel S. Fernandes, João Vogel, Åslög Hellström Johansson, Elias Philip, Anemon Puthuppallil Coutts, Shelagh B. Bal, Simerpreet Buck, Brian Legault, Catherine Blacquiere, Dylan Katzberg, Hans D. Field, Thalia S. Dizonno, Vanessa Gattringer, Thomas Jacobi, Christian Devroye, Annemie Lemmens, Robin Kristoffersen, Espen Saxhaug di Poggio, Monica Bandettini Ghiasian, Masoud Karapanayiotides, Theodoros Chatterton, Sophie Wronski, Miriam Ng, Karl Kahnis, Robert Geeraerts, Thomas Reiner, Peggy Cordonnier, Charlotte Middeldorp, Saskia Levi, Marcel van Gorp, Eric C. M. van de Beek, Diederik Brodard, Justine Kremer Hovinga, Johanna A. Kruip, Marieke J. H. A. Tatlisumak, Turgut Ferro, José Coutinho, Jonathan M. Arnold, Marcel Poli, Sven Heldner, Mirjam R. |
author_role |
author |
author2 |
Krzywicka, Katarzyna Mbroh, Joshua van de Munckhof, Anita van Kammen, Mayte Sánchez de Sousa, Diana Aguiar Lindgren, Erik Jood, Katarina Günther, Albrecht Hiltunen, Sini Putaala, Jukka Tiede, Andreas Maier, Frank Kern, Rolf Bartsch, Thorsten Althaus, Katharina Ciccone, Alfonso Wiedmann, Markus Skjelland, Mona Medina, Antonio Cuadrado‐Godia, Elisa Cox, Thomas Aujayeb, Avinash Raposo, Nicolas Garambois, Katia Payen, Jean‐Francois Vuillier, Fabrice Franchineau, Guillaume Timsit, Serge Bougon, David Dubois, Marie‐Cécile Tawa, Audrey Tracol, Clement De Maistre, Emmanuel Bonneville, Fabrice Vayne, Caroline Mengel, Annerose Michalski, Dominik Pelz, Johann Wittstock, Matthias Bode, Felix Zimmermann, Julian Schouten, Judith Buture, Alina Murphy, Sean Palma, Vincenzo Negro, Alberto Gutschalk, Alexander Nagel, Simon Schoenenberger, Silvia Frisullo, Giovanni Zanferrari, Carla Grillo, Francesco Giammello, Fabrizio Martin, Mar Morin Cervera, Alvaro Burrow, Jim Esperon, Carlos Garcia Chew, Beng Lim Alvin Kleinig, Timothy J. Soriano, Cristina Zimatore, Domenico S. Petruzzellis, Marco Elkady, Ahmed Miranda, Miguel S. Fernandes, João Vogel, Åslög Hellström Johansson, Elias Philip, Anemon Puthuppallil Coutts, Shelagh B. Bal, Simerpreet Buck, Brian Legault, Catherine Blacquiere, Dylan Katzberg, Hans D. Field, Thalia S. Dizonno, Vanessa Gattringer, Thomas Jacobi, Christian Devroye, Annemie Lemmens, Robin Kristoffersen, Espen Saxhaug di Poggio, Monica Bandettini Ghiasian, Masoud Karapanayiotides, Theodoros Chatterton, Sophie Wronski, Miriam Ng, Karl Kahnis, Robert Geeraerts, Thomas Reiner, Peggy Cordonnier, Charlotte Middeldorp, Saskia Levi, Marcel van Gorp, Eric C. M. van de Beek, Diederik Brodard, Justine Kremer Hovinga, Johanna A. Kruip, Marieke J. H. A. Tatlisumak, Turgut Ferro, José Coutinho, Jonathan M. Arnold, Marcel Poli, Sven Heldner, Mirjam R. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Scutelnic, Adrian Krzywicka, Katarzyna Mbroh, Joshua van de Munckhof, Anita van Kammen, Mayte Sánchez de Sousa, Diana Aguiar Lindgren, Erik Jood, Katarina Günther, Albrecht Hiltunen, Sini Putaala, Jukka Tiede, Andreas Maier, Frank Kern, Rolf Bartsch, Thorsten Althaus, Katharina Ciccone, Alfonso Wiedmann, Markus Skjelland, Mona Medina, Antonio Cuadrado‐Godia, Elisa Cox, Thomas Aujayeb, Avinash Raposo, Nicolas Garambois, Katia Payen, Jean‐Francois Vuillier, Fabrice Franchineau, Guillaume Timsit, Serge Bougon, David Dubois, Marie‐Cécile Tawa, Audrey Tracol, Clement De Maistre, Emmanuel Bonneville, Fabrice Vayne, Caroline Mengel, Annerose Michalski, Dominik Pelz, Johann Wittstock, Matthias Bode, Felix Zimmermann, Julian Schouten, Judith Buture, Alina Murphy, Sean Palma, Vincenzo Negro, Alberto Gutschalk, Alexander Nagel, Simon Schoenenberger, Silvia Frisullo, Giovanni Zanferrari, Carla Grillo, Francesco Giammello, Fabrizio Martin, Mar Morin Cervera, Alvaro Burrow, Jim Esperon, Carlos Garcia Chew, Beng Lim Alvin Kleinig, Timothy J. Soriano, Cristina Zimatore, Domenico S. Petruzzellis, Marco Elkady, Ahmed Miranda, Miguel S. Fernandes, João Vogel, Åslög Hellström Johansson, Elias Philip, Anemon Puthuppallil Coutts, Shelagh B. Bal, Simerpreet Buck, Brian Legault, Catherine Blacquiere, Dylan Katzberg, Hans D. Field, Thalia S. Dizonno, Vanessa Gattringer, Thomas Jacobi, Christian Devroye, Annemie Lemmens, Robin Kristoffersen, Espen Saxhaug di Poggio, Monica Bandettini Ghiasian, Masoud Karapanayiotides, Theodoros Chatterton, Sophie Wronski, Miriam Ng, Karl Kahnis, Robert Geeraerts, Thomas Reiner, Peggy Cordonnier, Charlotte Middeldorp, Saskia Levi, Marcel van Gorp, Eric C. M. van de Beek, Diederik Brodard, Justine Kremer Hovinga, Johanna A. Kruip, Marieke J. H. A. Tatlisumak, Turgut Ferro, José Coutinho, Jonathan M. Arnold, Marcel Poli, Sven Heldner, Mirjam R. |
description |
© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.562 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-21T14:36:07Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/54540 |
url |
http://hdl.handle.net/10451/54540 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ann Neurol. 2022 Oct;92(4):562-573 0364-5134 10.1002/ana.26431 1531-8249 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134605234667520 |